Synthesis and study of water-soluble asymmetric cationic porphyrins as potential photoinactivators of pathogens

Киселев, А. Н.; Lebedev, M. A.; Сырбу, С. А.; Yurina, Elena S.; Gubarev, Yury A.; Лебедева, Н.С.; Belyanina, N. A.; Shirokova, I. Yu.; Ковалишена, О. В.; Койфман, О. И.

doi:10.1007/s11172-022-3698-5

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…With this variant, an unsymmetrically substituted porphyrin [21] can form additional bonds between the inverted nitrogenous base and its peripheral substituent. The aim of this study was to study the interaction of monoheteryl-substituted porphyrin ((5-[4'-(N-methyl-1″,3″-benzoimidazol-2″yl)phenyl]-10,15,20-tris(3'-pyridyl) porphyrin (Fig.…”

Section: Introductionmentioning

confidence: 99%

Complexes of cationic non-symmetric porphyrin with synthetic and natural nucleic acids

Lebedeva,

Yurina,

Guseinov

et al. 2023

J Incl Phenom Macrocycl Chem

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Porphyrins, owing to their unique physicochemical properties, hold great potential as candidates for the synthesis of new materials and active pharmaceutical drugs. The introduction of functional groups into porphyrin structures enables the creation of novel compounds with nely tuned structural and optical properties, as well as complex-forming abilities. In this study, spectral and thermochemical investigations were conducted to explore the complex formation of a cationic porphyrin containing benzimidazole residues with synthetic (poly[d(GC)2], poly[d(AT)2]) and natural (ssDNA, ctDNA) nucleic acids. It was observed that the porphyrin forms complexes with poly[d(AT)2] and ssDNA, localized within the major groove of the biopolymer. Additionally, the porphyrin forms multiple intercalation complexes with varying geometries when interacting with poly[d(GC)2] and ctDNA. These ndings demonstrate a new potential for enhancing the selective binding of ligands with nucleic acids (NA). Moreover, the study highlights the methodological aspect that establishing the type of formed complexes based on ligands' electronic absorption spectra, known as " ngerprints," may lead to incorrect conclusions.

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Section: Introductionmentioning

confidence: 99%

Complexes of cationic non-symmetric porphyrin with synthetic and natural nucleic acids

Lebedeva,

Yurina,

Guseinov

et al. 2023

J Incl Phenom Macrocycl Chem

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show abstract

Porphyrin complexes of transition metals with a large dipole moment as active components of new film electret materials

Ageeva,

Bush,

Golubev

et al. 2023

Russ Chem Bull

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Complexes of Cationic Monoheteryl-Substituted Porphyrin with Synthetic and Natural Nucleic Acids

Lebedeva,

Yurina,

Guseinov

2023

Preprint

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Porphyrins, owing to their unique physicochemical properties, hold great potential as candidates for the synthesis of new materials and active pharmaceutical drugs. The introduction of functional groups into porphyrin structures enables the creation of novel compounds with finely tuned structural and optical properties, as well as complex-forming abilities. In this study, spectral and thermochemical investigations were conducted to explore the complex formation of a cationic porphyrin containing benzimidazole residues with synthetic (poly[d(GC)2], poly[d(AT)2]) and natural (ssDNA, ctDNA) nucleic acids. It was observed that the porphyrin forms complexes with poly[d(AT)2] and ssDNA, localized within the major groove of the biopolymer. Additionally, the porphyrin forms multiple intercalation complexes with varying geometries when interacting with poly[d(GC)2] and ctDNA. These findings demonstrate a new potential for enhancing the selective binding of ligands with nucleic acids (NA). Moreover, the study highlights the methodological aspect that establishing the type of formed complexes based on ligands' electronic absorption spectra, known as "fingerprints," may lead to incorrect conclusions.

show abstract

Synthesis and study of water-soluble asymmetric cationic porphyrins as potential photoinactivators of pathogens

Cited by 3 publications

References 34 publications

Complexes of cationic non-symmetric porphyrin with synthetic and natural nucleic acids

Complexes of cationic non-symmetric porphyrin with synthetic and natural nucleic acids

Porphyrin complexes of transition metals with a large dipole moment as active components of new film electret materials

Complexes of Cationic Monoheteryl-Substituted Porphyrin with Synthetic and Natural Nucleic Acids

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