Supramolecular hydrogel-loaded Prussian blue nanoparticles with photothermal and ROS scavenging ability for tumor postoperative treatments

Recent advances in hydrogels for preventing tumor recurrence

“…It was verified that this integrated platform elicited significant anticancer effects and wound healing acceleration in in vitro and in vivo experiments. 181…”

Recent advances in Prussian blue-based photothermal therapy in cancer treatment

“…[55][56][57] PB NPs have mesoporous, hollow, and core-shell structures that can efficiently encapsulate, load, or covalently couple various chemotherapeutic agents, significantly improving the targeting of therapeutics. [58][59][60] The drug delivery system will accumulate in the tumour through the EPR effect, and drug release is accelerated with increasing ambient tempera- ture during PTT. To reduce the non-targeted drug release, the design of responsive/triggerable nanodrugs is a trend in the development of chemotherapy.…”

Fabrication of Cyclodextrin-Based Hydrogels for Wound Healing: Progress, Limitations, and Prospects

“…Due to HMPB having peroxidase and superoxide dismutase mimetic catalytic activity and free radical scavenging capacity, 73,74 HMPB-Dox@Gel could reduce wound inflammation and increase collagen deposition in diabetic mice, and accelerate the wound healing rate compared to commercial wound dressings (Figure 4A). 75 Zhang et al fabricated a quaternized CS-CD-Ad/graphene oxide (QCS-CD-Ad/GO) supramolecular hydrogel, which had inherent and photo-thermal antibacterial properties, electrical conductivity, self-healing, and good biocompatibility, which accelerated the in vivo wound healing process of full-thickness wounds in mice as compared to commercial dressings (Tegader) and promoted epidermis and granulation tissue thickness, collagen formation, and upregulation of VEGF expression (Figure 4B). 76 However, compared to nonstimulus-responsive hydrogels, stimulus-responsive hydrogels are able to precisely control fundamental properties of materials such as expansion, porosity, physical structure, modulus, and drug release behavior through a series of triggering mechanisms, including In addition, loading bioactive molecules or hydrophobic drugs into hydrogels through host−guest interactions can broaden the range of loading drugs, improve the loading efficiency and utilization rate, and maintain their biological activity to the maximum extent.…”

“…(A-I) Schematic illustration of HMPB-DOX@GEL supramolecular hydrogel; (A-II) in vitro RAW 264.7 cells intracellular ROS fluorescence imaging incubated with PBS, GEL, or HMPB@GEL (treated with 1 mM H 2 O 2 for 2 h). Reproduced with permission from ref . Copyright 2022 Elsevier.…”