Recent advances in Prussian blue-based photothermal therapy in cancer treatment

Tang, Kaizhi; Li, Xiao; Hu, Yanling; Zhang, Xiaonan; Lu, N.; Fang, Qiang; Shao, Jinjun; Li, Shengke; Xiu, Weijun; Song, Yanni; Yang, Dongliang; Zhang, Junjie

doi:10.1039/d3bm00509g

Cited by 18 publications

(4 citation statements)

References 168 publications

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“…Consequently, tumor tissues often develop abnormal vascular networks, causing stasis and reduced blood flow, which in turn leads to tumor hypoxia. 118–121 Under conditions of inadequate oxygen supply, the effectiveness of tumor treatments, including CMT, RT, and phototherapy, is limited, resulting in severe consequences such as tumor recurrence and high mortality rates. 118,122,123 Notably, quinones, nitroaromatics, azobenzene derivatives, and other functional groups serve as examples of hypoxia-responsive moieties.…”

Section: Tme-triggered Degradable Silica Nanoparticles For Precision ...mentioning

confidence: 99%

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Zhang,

Tang,

Liu

et al. 2024

Nanoscale Horiz.

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Section: Tme-triggered Degradable Silica Nanoparticles For Precision ...mentioning

confidence: 99%

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Zhang,

Tang,

Liu

et al. 2024

Nanoscale Horiz.

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“…PB is a clinical drug approved by the United States Food and Drug Administration (FDA) that offers significant advantages, including an effective iron ion center, strong light absorption, and high nearinfrared photothermal conversion efficiency. 28,29 PB exhibits robust charge transfer absorption at 700 nm and possesses a substantial absorption peak in the near-infrared range, enabling efficient thermal relaxation upon irradiation. 30,31 These properties make PB an excellent drug carrier and a photothermal agent for combined photothermal-chemotherapy in vivo.…”

Section: Introductionmentioning

confidence: 99%

Red cell membrane-coating Prussian blue for combined photothermal and NO gas therapy for nasopharyngeal carcinoma

Wang,

Cheng,

Xing

et al. 2024

J. Mater. Chem. B

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“…Due to its easy-to-regulate structure (such as solid, mesoporous, core–shell and hollow structures) and rich iron suspended bonds, nano PB may be a potential drug delivery system . The electron can transition in the Fe-CN-Fe of the Prussian blue structure, which makes nano PB have strong absorption in the near-infrared region and become a potential photothermal conversion agent . Because of its rich redox potential and catalytic activity, − nano PB may be a potential bioactive drug. − In addition, the PB structure has iron dangling bonds and vacancies, which makes its surface easy to be modified, thus meeting the requirements of clinical medical applications.…”

Section: Introductionmentioning

confidence: 99%

Prussian Blue Nanoparticle: From a Photothermal Conversion Agent and a Drug Delivery System, to a Bioactive Drug

Gao,

Wang,

Zheng

et al. 2024

Acc. Mater. Res.

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Metrics & MoreArticle Recommendations CONSPECTUS: Nanomedicine is an interdisciplinary science that involves chemistry, materials, physics, engineering, biology, and medicine. The main focus of nanomedicine is on drug carriers: how to improve drug efficacy and reduce side effects. In order to further improve the synergistic and detoxifying effects of nanomedicines, scientists have adopted a multifunctional integration strategy. However, versatility brings complex components and ignores the synergistic effects between components. The lack of in-depth research on the bioactivities of nanocarriers hinders the development and clinical translation of nanomedicine.In the past decade, scientists have gradually discovered that nanomaterials show excellent bioactivities, becoming an enormous treasure trove for disease prevention and treatment. Among numerous bioactive materials, Prussian blue (PB) is a clinical antidote approved by the US Food and Drug Administration, showing excellent biosafety. However, clinically approved PB owns many drawbacks, and it is difficult to satisfy the requirements of disease prevention and treatment. When the size reduces to the nanoscale, nano PB shows both unique properties of nanomaterials and the enhancement of its performance and bioactivities. Due to its easy-to-regulate structure and rich iron suspended bonds, nano PB may be a potential drug delivery system. Electron transition in the Fe-CN-Fe structure endows nano PB with strong absorbance in the near-infrared region, becoming a potential photothermal conversion agent. Furthermore, due to its rich redox potential and catalytic activities, nano PB may be a bioactive drug with a great translational clinic prospect.In this Account, we describe our exploration of nano PB as a photothermal conversion agent, a drug delivery system and a bioactive drug in the prevention and treatment of disease over the past decade. We first summarize the application of nano PB as a photothermal conversion agent and a drug delivery system in the treatment of cancer, and then focus on our recent progress in the application of nano PB as a bioactive drug in the prevention and treatment of diseases (such as tumors, neurodegeneration, cerebrovascular disease, bone-related degenerative disease, gastrointestinal disease, and skin lesions). Finally, we look forward to the open challenges and future developments in this rapidly developing field. We hope this Account will help readers understand nano PB not only as a photothermal conversion agent and drug carrier but also as a bioactive drug, thus realizing its great potential in disease prevention and treatment. These studies also provide a research paradigm for bioactive nanomaterials. As our and other teams continue to explore this promising material, the unique characteristics of bioactive nanomaterials represented by nano PB may bring further exciting developments in disease prevention and treatment.

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Recent advances in Prussian blue-based photothermal therapy in cancer treatment

Abstract: Malignant tumours are a serious threat to human health. Traditional chemotherapy has achieved breakthrough improvements but also has significant detrimental effects, such as the development of drug resistance, immunosuppression, and...

Cited by 18 publications

References 168 publications

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Red cell membrane-coating Prussian blue for combined photothermal and NO gas therapy for nasopharyngeal carcinoma

Prussian Blue Nanoparticle: From a Photothermal Conversion Agent and a Drug Delivery System, to a Bioactive Drug

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