Suppressive effects of extracts from the aerial part of <i>Coriandrum sativum</i>
 L. on LPS-induced inflammatory responses in murine RAW 264.7 macrophages

Wu, Trang-Tiau; Tsai, Chia-Wen; Yao, Hsien-Tsung; Lii, Chong‐Kuei; Chen, Haw‐Wen; Wu, Yu-Ling; Chen, Pei-Yin; Liu, Kaili

doi:10.1002/jsfa.4023

Cited by 44 publications

(27 citation statements)

References 36 publications

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“…Wu ve arkadaşlarının 2010 yılında yaptığı bir çalışmada, kişnişin toprak üstü kısımlarının etanollü ekstrelerinin antienflamatuvar özellikleri, olası etki mekanizmaları incelenmiş ve kişniş yaprakları ile saplarının NO ve prostaglandin üretimini azalttığı gözlenmiştir (73). Özbek ve arkadaşlarının yaptığı bir çalışmada, kişniş uçucu yağ ekstresinin farelerde LD 50 dozu düzeyinin 2,257 mL/kg olarak hesaplandığı, sıçanlarda Carrageenan'la oluşturulmuş sağ arka pençe ödemi modelinde indometazinden daha zayıf bir antienflamatuvar aktivite gösterdiği ve bu etkinin uçucu yağı oluşturan komponentlerden en az ikisi tarafından meydana getirildiği bildirilmiştir (74).…”

Section: Antienflamatuvar Etkiunclassified

Kişniş (Coriandrum sativum L.) Üzerine Bir Derleme 1.Giriş Geçmişten beri halk hekimliğinde sıklıkla faydalanılan bitkiler, birçok hastalığın tedavisinde kullanılmıştır. Yaklaşık 12000 tür ve türaltı seviyede takson ile kuzey yarımkürede oldukça zengin bir floraya sahip ülkelerden biri olan Türkiye de de bitkisel kaynaklı ilaçlara başvurulmaya devam edilmektedir. Son zamanlarda, başta Avrupa olmak üzere tüm dünyada bir "doğaya dönüş" akımı başlamıştır. Bunun sonucu olarak da yakın zamana kadar s

Deniz¹,

Yeğenoğlu²,

Şahne³

et al. 2018

mpj

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Section: Antienflamatuvar Etkiunclassified

Kişniş (Coriandrum sativum L.) Üzerine Bir Derleme 1.Giriş Geçmişten beri halk hekimliğinde sıklıkla faydalanılan bitkiler, birçok hastalığın tedavisinde kullanılmıştır. Yaklaşık 12000 tür ve türaltı seviyede takson ile kuzey yarımkürede oldukça zengin bir floraya sahip ülkelerden biri olan Türkiye de de bitkisel kaynaklı ilaçlara başvurulmaya devam edilmektedir. Son zamanlarda, başta Avrupa olmak üzere tüm dünyada bir "doğaya dönüş" akımı başlamıştır. Bunun sonucu olarak da yakın zamana kadar s

Deniz¹,

Yeğenoğlu²,

Şahne³

et al. 2018

mpj

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“…The overproduction of inflammatory mediators can lead to complications such as septic shock, cancer, diabetes, atherosclerosis, and obesity (13). NO and prostaglandin E 2 are produced by activation of iNOS and COX-2, respectively.…”

Section: 한국식품과학회지 제 48 권 제 6 호 (2016)mentioning

confidence: 99%

Anti-inflammatory effect of Geranium thunbergii on lipopolysaccharide-stimulated RAW 264.7 cells

Kwon¹,

Kim²,

Park³

et al. 2016

Korean Journal of Food Science and Technology

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Geranium thunbergii is a perennial plant commonly used as an oriental medicine for prevention of diarrhea, constipation, and gastrointestinal disorders. However, its anti-inflammatory effect has not been evaluated thus far. Therefore, the present study aimed to investigate the anti-inflammatory effect of G. thunbergii. In this study, G. thunbergii extracted with methanol; this methanol extract was further partitioned using various solvents, and G. thunbergii ethyl acetate fraction (GTEF) was obtained. To determine the anti-inflammatory activity of G. thunbergii, the effects of GTEF on nitric oxide (NO) production in lipopolysaccharide-stimulated RAW 264.7 cells were evaluated. GTEF suppressed NO production in a dose-dependent manner without any toxic effects. In addition, western blotting was performed to examine the effect of GTEF on expression of inducible nitric oxide synthase and cyclooxygenase-2. These results suggest that GTEF as a phytoextract may be useful for the prevention or treatment of inflammation.

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“…9 Previous studies reported that leaves of CS decreased lipopolysaccharide-induced nitric oxide (NO) production and had a NO scavenging effect in RAW 264.7 macrophages. 10 Moreover, it has anti-inflammatory potential in ultraviolet erythema and antioxidant effects in rats fed a high-fat diet. 11 Furthermore, we previously demonstrated that linoleic acid and linolenic acid in CS protect human skin keratinocytes against H 2 O 2 -induced oxidative damage, possibly by regulating antioxidative defense enzymes such as heme oxygenase-1 (HO-1) and total glutathione (GSH) through nuclear factor erythroid-derived 2-related factor 2.…”

Section: Introductionmentioning

confidence: 99%

Coriander Alleviates 2,4-Dinitrochlorobenzene-Induced Contact Dermatitis-Like Skin Lesions in Mice

Park

Kim²,

Lim³

et al. 2014

Journal of Medicinal Food

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Contact dermatitis (CD) is a pattern of inflammatory responses in the skin that occurs through contact with external factors. The clinical picture is a polymorphic pattern of skin inflammation characterized by a wide range of clinical features, including itching, redness, scaling, and erythema. Coriandrum sativum L. (CS), commonly known as coriander, is a member of the Apiaceae family and is cultivated throughout the world for its nutritional and culinary values. Linoleic acid and linolenic acid in CS have various pharmacological activities. However, no study of the inhibitory effects of CS on CD has been reported. In this study, we demonstrated the protective effect of CS against 2,4-dinitrochlorobenzene-induced CD-like skin lesions. CS, at doses of 0.5-1%, applied to the dorsal skin inhibited the development of CD-like skin lesions. Moreover, the Th2-mediated inflammatory cytokines, immunoglobulin E, tumor necrosis factor-α, interferon-γ, interleukin (IL)-1, IL-4, and IL-13, were significantly reduced. In addition, CS increased the levels of total glutathione and heme oxygenase-1 protein. Thus, CS can inhibit the development of CD-like skin lesions in mice by regulating immune mediators and may be an effective alternative therapy for contact diseases.

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Suppressive effects of extracts from the aerial part of Coriandrum sativum L. on LPS-induced inflammatory responses in murine RAW 264.7 macrophages

Abstract: Our data demonstrated that aerial parts of CSEE have a strong anti-inflammatory property which inhibits pro-inflammatory mediator expression by suppressing NF-kappaB activation and MAPK signal transduction pathway in LPS-induced macrophages.

Cited by 44 publications

References 36 publications

Anti-inflammatory effect of Geranium thunbergii on lipopolysaccharide-stimulated RAW 264.7 cells

Coriander Alleviates 2,4-Dinitrochlorobenzene-Induced Contact Dermatitis-Like Skin Lesions in Mice

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