Suppressive effects of Chelidonium majus methanol extract in knee joint, regional lymph nodes, and spleen on collagen-induced arthritis in mice

Chelidonium majus – an Integrative Review: Traditional Knowledge versus Modern Findings

“…This action was characterized by a decreased production of TNF-alpha, IL-6, Interferon(IFN)-gamma, B cells, gammadelta T cells (in spleen) and an increased proportion of CD4+CD25+ regulatory T cells. The serum levels of IgG and IgM RA factors were decreased [10].…”

Immunosuppressive effects of an ethyl acetate extract from Urtica dentata Hand on skin allograft rejection

“…CD4 + CD25 + T regulatory cells have been identified to possess immune regulatory activity and prevent a number of autoimmune disorders (Cyndi et al, 2003;Morgan et al, 2005;Lee et al, 2007). The proportion of CD4 + CD25 + T regulatory cells in spleen lymphocytes of recipients was analyzed by FACS.…”

“…Additionally, previous studies have found that CD4 + CD25 + T regulatory cells (Tregs) possess potent ability to suppress T cell responses both in vivo and in vitro (Stephens et al, 2001;Chatila, 2005). They were involved in the maintenance of peripheral selftolerance (Hori et al, 2003) by efficiently suppressing the activation of autoreactive T cells, which might help to treat auto-immune diseases and to inhibit allograft rejection (Stephens et al, 2001;Cyndi et al, 2003;Morgan et al, 2005;Lee et al, 2007).…”

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

“…Table 1 shows that many of them act by scavenging ROS and other free radicals, and by decreasing the radiation-induced increase in the level of TGF-β1, TNF-α, IFN-γ, WBC influx in tissue, IL-1β, IL-2, IL-4, IL-6, IL-12, IL-17, MIP-1α, VEGF, etc, all of them being key players in inflammatory response (Xie et al, 2006;Kim et al, 2007;Lee et al, 2007;Day et al, 2008;Qiu et al, 2008;Christofidou-Solomidou et al, 2011;Hei et al, 2011;Janko et al, 2012;Monceau et al, 2013;Pragya et al, 2014). Others act against radiation exposure by inducing the expression of Mn-SOD, GSH, CAT, and GPx, the important members of antioxidant defence system (Han et al, 2005;Gottfredsen et al, 2014) or modulate the immune response against radiation exposure Qiu et al, 2008;Pragya et al, 2014;Yu et al, 2014).…”

“…Reports also showed that the methanolic extract of C. majus (CME) administered orally to collageninduced arthritis (CIA) mice (at a dose of 400 mg/kg body weight (b.w. ), once a day for 4 weeks) resulted in significant decrease (p<0.001) in the absolute number of CD19+B cells, and an increase (p<0.05) in the absolute number of CD4+CD25+ regulatory T cells in spleen in comparison to the CIA control mice (CT) (Lee et al, 2007). In the same study, it was also shown that TNF-α (p<0.05), IL-6 (p<0.01), interferon-gamma (IFN-γ) (p<0.05), immunoglobulin (IgG, p<0.05; IgM, p<0.01) productions in spleen and serum were reduced by CME in compared to CT mice.…”