Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

Kma, Lakhan

doi:10.7314/apjcp.2014.15.6.2405

Cited by 33 publications

(25 citation statements)

References 210 publications

(210 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the surgery, inflammatory mediators, like C-reactive protein, cortisol hormone and cytokines, are released in large abundance, which activate the inflammatory cells and constantly exacerbate the inflammatory responses. A researcher proposed that the balance between pro-inflammatory cytokines (IL-8 and tumor necrosis factor-α) and antiinflammatory cytokines (IL-4 and IL-10) was beneficial to eliminating the adverse impacts result from traumatic inflammatory responses and promoting the recovery of diseases (Allahtavakoli et al, 2011;de Lima et al, 2011;Sun et al, 2011;Gäbel et al, 2013;Shen et al, 2013;Verit et al, 2013;Yang et al, 2013;Zhao et al, 2013;Guo et al, 2014;Kma et al, 2014;Lu et al, 2014;Pandurangan et al, 2014;Soliman et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Influence of Propofol, Isoflurane and Enflurance on Levels of Serum Interleukin-8 and Interleukin-10 in Cancer Patients

Liu

2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Objective: To observe the influence of propofol, isoflurane and enflurance on interleukin-8 (IL-8) and IL-10 levels in cancer patients. Methods: Ninety cancer patients with selective operation from March 2011 to May 2014 were randomly divided into group A (34 cases), group B (28 cases) and group C (28 cases). Intramuscular injections of scopine hydrochloride and phenobarbital sodium were routinely conducted to 3 groups. After general anesthesia was induced, tracheal intubations were given. During the maintenance of anesthesia, 0.5~1.0 mg/ kg propofol was intravenously injected to group A discontinuously, while continuous suctions of isoflurane and enflurance were subsequently performed to group B and C correspondingly. Clinical outcomes, postoperative complications as well as serum IL-8 and IL-10 levels before operation (T0), at the time of skin incision (T1), 3 h after the beginning of the operation (T2) and 24 h (T3) and 72 h (T4) after the operation were observed among 3 groups. Results: Operations in all groups were successfully completed. The rates of surgery associated complications were 8.82% (3/34), 7.14% (2/28) and 7.14% (2/28) in group A, B and C, respectively, and there were no significant differences (P>0.05). Serum IL-8 and IL-10 levels increased gradually from the beginning of the operation and reached the peak at T3, and were evidently higher at each time point than at T0 (P<0.01). At T1, serum IL-8 and IL-10 levels had no significant differences among 3 groups (P>0.05), but the differences were significant at T2, T3 and T4 (P<0.05). Moreover, correlation analysis suggested that serum IL-8 level was in positive relation with IL-10 level (r=0.952, P<0.01). Conclusions: Propofol, which is better in inhibiting serum IL-8 secretion and improving IL-10 secretion than isoflurane and enflurance, can be regarded as a preferable anesthetic agent in inhibiting traumatic inflammatory responses.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of Propofol, Isoflurane and Enflurance on Levels of Serum Interleukin-8 and Interleukin-10 in Cancer Patients

Liu

2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Investigations to elucidate the underlying molecular mechanisms of TOMs have led to the establishment of proper medication protocols and development of promising drugs with decreased side effects. A number of medicinal plants utilized for the treatment of a number of ROS-related diseases including rheumatoid arthritis, cancer, aging and other inflammatory diseases have been identified to exhibit antioxidative, anti-inflammatory, antimicrobial and immunostimulatory activities (16)(17)(18)(19)(20). These results indicate that plants may include specific compounds that may protect against radiation-mediated damage as well, which is closely associated with ROS-induced damage.…”

Section: Traditional Oriental Medicinesmentioning

confidence: 99%

“…A variety of TOMs have been reported to contain antioxidant phytochemicals and to have the potential to function in a radioprotective role in various systems (16)(17)(18)(19)(20). The most appropriate approach to screening candidates as potential radioprotectors is to assess whether an active constituent or a number of compounds with synergistic effects have antioxidative, anti-inflammatory, antimicrobial or immunostimulatory activities.…”

Section: Toms As Radioprotectorsmentioning

confidence: 99%

“…Previous studies have been conducted to identify traditional oriental medicines (TOMs) that may serve as potent radioprotectors due to their safety and low toxicity, which have been confirmed by empirical testing and their clinical use in Asian countries (16)(17)(18)(19)(20). These compounds have been reported to have antioxidant properties, which may neutralize radiation-induced damage, including oxidative stress caused by reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

et al. 2017

View full text Add to dashboard Cite

Abstract. The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation-induced damage. The potential for antioxidants to decrease normal tissue damage induced by radiation has been investigated in animal models for a number of decades. In attempts for radioprotection, certain synthetic chemicals are suggested as antioxidants and normal tissue protectors against radiation-induced damage, but they have exhibited limitations in pharmacological application due to undesirable effects and high toxicities at clinical doses. The present review focuses on the radioprotective efficacy of traditional oriental medicines with the advantage of low toxicity at pharmacological doses and how such treatments may influence various harmful effects induced by radiation in vitro and in vivo. In addition, medicinal plants and their active constituents with biological activities that may be associated with alleviation of radiation-induced damage through antioxidant, anti-inflammatory, wound healing and immunostimulatory properties are discussed.

show abstract

“…37 Evidences of curcumin showing its potential to scavenge various free radical species in vitro, reduction of radiation-induced fibrosis thereby increasing survival in mice, and its triggered radiosensitization of cancer cells and radioprotection of normal cells probably places it as a potential candidate against radiological damages 38 .…”

Section: Radioprotective Propertiesmentioning

confidence: 99%

Untitled

2016

IJPSR

View full text Add to dashboard Cite

Antioxidant potentials and radioprotective properties of curcumin were studied. Free radical scavenging activity of curcumin was measured spectrophotometrically using ferric ion reducing power assay, DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical test, hydroxyl radical scavenging activity assay, nitric oxide scavenging assay and superoxide scavenging capacity. The antioxidant properties depended upon concentration of curcumin in the reaction mixture. Curcumin exhibited good protection against low LET radiation-induced DNA damage. Treatment of ethanolic solutions of curcumin before irradiation significantly reduced comet tail DNA and length (P < 0.05.) in bone marrow cells of rat as revealed by alkaline single cell gel electrophoresis. Treatment of curcumin solutions to plasmid (pBR322) DNA prior to exposure of radiation under in vitro condition protect the DNA damage as indicated by significant reduction of the gamma radiation-induced conversion of CCC (covalently closed circular) to OC (open circular) form. The findings indicate that curcumin possesses promising antioxidant and radioprotective properties, and hence, has an important role in radiation countermeasures.

show abstract

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

Cited by 33 publications

References 210 publications

Influence of Propofol, Isoflurane and Enflurance on Levels of Serum Interleukin-8 and Interleukin-10 in Cancer Patients

Influence of Propofol, Isoflurane and Enflurance on Levels of Serum Interleukin-8 and Interleukin-10 in Cancer Patients

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

Untitled

Contact Info

Product

Resources

About