Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol

Lee, Eun Hye; Shin, Jin Hak; Kim, Seon Sook; Joo, Ji-Hye; Choi, Eun‐Mi; Seo, Su Ryeon

doi:10.3390/ijms20143510

Cited by 15 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Marine algae are a public health priority for exploring effective natural antimicrobial agents with better potential, fewer side effects than antibiotics, good bioavailability, and minimal toxicity [19]. Most studies on C. acnes-induced inflammatory cytokines were performed in murine models [3,20,21]. MIP-2 in mice is regarded as a functional homologue of IL-8 in humans, which, targeted against C. acnes, induces inflammation in mice [22].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

et al. 2020

View full text Add to dashboard Cite

Acne vulgaris is a chronic inflammatory condition of skin sebaceous follicles. To explore its effects on acne vulgaris, we investigated the antibacterial and anti-inflammatory activities of Sargassum miyabei Yendo (a brown alga) ethanolic extract (SMYEE) on Cutibacterium acnes (C. acnes)-stimulated inflammatory responses, both in vivo and in vitro. To induce inflammation in vivo, C. acnes was intradermally injected into the dorsal skin of mice, to which SMYEE was applied. The antimicrobial activity of SMYEE was evaluated by the determination of minimum inhibitory concentrations (MICs). To explore in vitro anti-inflammatory effects, HaCaT cells were stimulated with C. acnes after treatment with SMYEE. The levels of IL-8 and the underlying molecular effects in C. acnes-stimulated HaCaT cells were assessed by enzyme-linked immunosorbent assay, Western blotting, and an electrophoretic mobility shift assay. Mouse skin lesions improved after treatment with SMYEE (50 μg/mouse). Neutrophil infiltration was significantly reduced in SMYEE-treated compared to SMYEE-untreated skin lesions. SMYEE reversed the C. acnes-induced increase in IL-8 levels in HaCaT cells and suppressed dHL-60 cell migration. SMYEE also inhibited C. acnes-induced phosphorylation of the extracellular signal-regulated kinase and inhibited activator protein-1 signaling. SMYEE may be a useful treatment for C. acnes-induced acne vulgaris.

show abstract

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Some small peptides, such as melittin and short lipopeptides, can protect cells from inflammatory responses induced by C. acnes and may even have direct antibacterial effects [ 48 ]. Several biologically active compounds extracted from plants have been found to inhibit the occurrence of acne to varying degrees [ 49 , 50 , 51 , 52 ]. The present study, showing that endogenous FGF21 can suppress the inflammation induced by C. acnes , suggests that the administration of exogenous FGF21 can be used to prevent inflammation caused by C. acnes invasion.…”

Section: Discussionmentioning

confidence: 99%

Suppression of Cutibacterium acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin

Shen

Zhang

et al. 2022

IJMS

View full text Add to dashboard Cite

Cutibacterium acnes (C. acnes) is a common commensal bacterium that is closely associated with the pathogenesis of acne. Fibroblast growth factor 21 (FGF21), as a favorable regulator of glucose and lipid metabolism and insulin sensitivity, was recently shown to exert anti-inflammatory effects. The role and mechanism of FGF21 in the inflammatory reactions induced by C. acnes, however, have not been determined. The present study shows that FGF21 in the dermis inhibits epidermal C. acnes-induced inflammation in a paracrine manner while it functions on the epidermal layer through a receptor complex consisting of FGF receptor 1 (FGFR1) and β-Klotho (KLB). The effects of FGF21 in heat-killed C. acnes-induced HaCaT cells and living C. acnes-injected mouse ears were examined. In the presence of C. acnes, FGF21 largely counteracted the activation of Toll-like receptor 2 (TLR2), the downstream nuclear factor-κB (NF-κB), and mitogen-activated protein kinase (MAPK) signaling pathways induced by C. acnes. FGF21 also significantly reduced the expression of proinflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α. Taken together, these findings indicate that FGF21 suppresses C. acnes-induced inflammation and might be used clinically in the management and treatment of acne.

show abstract

“…P. acnes is involved in developing cutaneous inflammation. The peptidoglycan of P. acnes can activate monocytes to produce cytokines such as IL-1β, IL-8, and TNF-α, which cause granulomatous responses in inflammatory skin disorder (Kistowska et al, 2014;Lee et al, 2019).…”

Section: The Skin Microbiota Has Natural Antimicrobial Propertiesmentioning

confidence: 99%

Exploitation of Skin Microbiota in Wound Healing: Perspectives During Space Missions

Marvasi

Monici

Pantalone

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Wound healing is slowed in Space. Microgravity and possible physical factors associated with Space affect alterations in fibroblast, matrix formation, dysregulation in apoptosis and inflammation. The microbial populations settled on skin, space modules, in space suits, are also playing a pivotal role, as wound healing is also affected by the microbial community. We propose a perspective that includes four domines for the application of human skin microbiota for wound healing in Space: The natural antimicrobial properties of the skin microbiota, the crosstalk of the skin microbiota with the immune system during wound healing, the contribution of the microbiota in precision medicine, and the role of gut-skin and gut-brain axes. A stronger understanding of the connections and metabolic network among bacteria, fungi, the host’s immune system and the host metabolism will support the basis for a better wound healing in Space.

show abstract

Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol

Cited by 15 publications

References 38 publications

Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

Suppression of Cutibacterium acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin

Exploitation of Skin Microbiota in Wound Healing: Perspectives During Space Missions

Contact Info

Product

Resources

About