Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

Yim, Mi‐Jin; Lee, Jeong Min; Kim, Hyunsoo; Choi, Grace; Kim, Young‐Mog; Lee, Daesung; Choi, Il‐Whan

doi:10.3390/nu12092620

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Overall, S. hemiphyllum and S. miyabei Yendo, the two species containing the highest TPC and TFC, displayed the strongest antioxidant capacity. In addition to our findings, the strong antioxidant capacities, anti-inflammatory activities, and antihyperglycemic activities of S. hemiphyllum and S. miyabei Yendo have been previously reported [22], [23,24], [25,26]. Tyrosinase is critical in the melanogenesis and enzymatic browning.…”

Section: Discussionsupporting

confidence: 86%

The Comparison of Total Phenolics, Total Antioxidant, and Anti-Tyrosinase Activities of Korean Sargassum Species

Baek

Cao

Jeong

et al. 2021

Journal of Food Quality

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Sargassum species, a group of marine brown algae consumed in Asian countries, have shown various health benefits, such as improving the conditions of cardiovascular disease, osteoarthritis, and hypopigmentation. Also, these benefits are associated with their phenolic content and strong antioxidant capacities. However, the antioxidant capacities of different Sargassum species had not been thoroughly explored and compared. Thus, this study aimed to compare the total phenolic contents, total flavonoid contents, total antioxidant capacities, and anti-tyrosine activity of eleven Sargassum species harvested off the Korean coast. The results revealed that the total phenolic content (from 20.57 to 88.97 mg gallic acid equivalent/g dry weight (dw)), flavonoid content (from 22.08 to 82.33 mg quercetin equivalent/g dw), anti-tyrosinase activity (from 13.30 to 126.30 mg kojic acid equivalent/dw), and antioxidant capacities of the 11 Sargassum species had wide ranges. Among them, S. miyabei Yendo and S. hemiphyllum showed the highest total antioxidant capacities while S. miyabei Yendo exhibiting the highest total phenolic and flavonoid contents. The highest anti-tyrosinase activity was seen in S. fillicinum and S. yendoi. Sargahydroqunoic acid and sargachromanol, two alga-derived meroterpenoid compounds with strong antioxidant activity, were detected and quantified in S. miyabei Yendo and S. serratifolium. Our findings guarantee further investigation of the health benefits of Sargassum species and maximize the commercial usage of these species.

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Section: Discussionsupporting

confidence: 86%

The Comparison of Total Phenolics, Total Antioxidant, and Anti-Tyrosinase Activities of Korean Sargassum Species

Baek

Cao

Jeong

et al. 2021

Journal of Food Quality

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show abstract

“…Distinct Sargassum species have demonstrated efficacy in mitigating various dermal conditions including UVB photodamage, acne-induced inflammation, and hyperpigmenta-tion [32,33] as well as inflammation induced by fine particulate matter and compromised skin barrier functionality [34]. Phenolics are secondary metabolites that allow algae to adapt to environmental stressors such as UV radiation, heat, salinity, or cold.…”

Section: Discussionmentioning

confidence: 99%

Anti-skin Aging Potential of Sargassum thunbergii Ethanolic Extract: Antioxidant, Anti-inflammatory, and Antiwrinkle Effects on L929 Fibroblast Cells

Cui,

Qu,

Qiao

et al. 2023

Journal of Food Processing and Preservation

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Increasing life expectancy of the human population has created a demand for functional food with anti-skin aging properties. Skin aging is a degenerative process caused by oxidative stress, inflammation, and matrix destruction. Some secondary metabolites isolated from marine macroalgae have been shown to exhibit potential dermatological benefits. The present study investigated the skin-protective properties of the ethanolic extract from Sargassum thunbergii (STEE) via antioxidant, anti-inflammatory, and antiwrinkle effects on mouse fibroblast L929 cells. The optimal extraction conditions for STEE were determined as follows: ratio of liquid to solid 25 : 1 mL/g, concentration of ethanol 40.2%, and extraction time 40 min. STEE was further purified by adsorption using a macroporous resin, SP700. STEE exhibited high DPPH radical and hydroxyl scavenging activity in vitro, enhanced the viability of H2O2-treated L929 cells, and reduced intracellular ROS generation in a dose-dependent manner. Superoxide dismutase and glutathione peroxidase activities and total antioxidant capacity in H2O2-treated L929 cells were increased while malondialdehyde content was markedly reduced by pretreatment with STEE. The inhibitory effect of STEE on H2O2-induced inflammation was shown by the downregulation of tumor necrosis factor-α, interleukin-6, cyclooxygenase-2, and inducible nitric oxide synthase. Furthermore, STEE reduced the matrix metalloproteinase-2 expression and inhibited collagenase and elastase activities. Moreover, STEE was nonirritating to human skin at 100 mg/mL according to the in vitro skin irritation test using EpiSkin™. Hemolysis assay showed that the hemolysis EC50 (1275 μg/mL) of STEE is much higher than the maximum effective concentration (125 μg/mL) against H2O2 exposure. Our results demonstrate that STEE may be a good candidate for the development of anti-skin aging functional food and cosmetic products.

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“…Automatic assessments of skin disease severity is important in the medical field. Acne vulgaris is a common chronic inflammatory skin disease involving pilosebaceous units characterized by skin with seborrhea, comedones, papules, nodules, pimples and scarring [1,2]. It has affected up to 650 million people and 85% of the adolescents and young adults in the world [3].…”

Section: Introductionmentioning

confidence: 99%

A cell phone app for facial acne severity assessment

et al. 2022

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Acne vulgaris, the most common skin disease, can cause substantial economic and psychological impacts to the people it affects, and its accurate grading plays a crucial role in the treatment of patients. In this paper, we firstly proposed an acne grading criterion that considers lesion classifications and a metric for producing accurate severity ratings. Due to similar appearance of acne lesions with comparable severities and difficult-to-count lesions, severity assessment is a challenging task. We cropped facial skin images of several lesion patches and then addressed the acne lesion with a lightweight acne regular network (Acne-RegNet). Acne-RegNet was built by using a median filter and histogram equalization to improve image quality, a channel attention mechanism to boost the representational power of network, a region-based focal loss to handle classification imbalances and a model pruning and feature-based knowledge distillation to reduce model size. After the application of Acne-RegNet, the severity score is calculated, and the acne grading is further optimized by the metadata of the patients. The entire acne assessment procedure was deployed to a mobile device, and a phone app was designed. Compared with state-of-the-art lightweight models, the proposed Acne-RegNet significantly improves the accuracy of lesion classifications. The acne app demonstrated promising results in severity assessments (accuracy: 94.56%) and showed a dermatologist-level diagnosis on the internal clinical dataset.The proposed acne app could be a useful adjunct to assess acne severity in clinical practice and it enables anyone with a smartphone to immediately assess acne, anywhere and anytime.

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Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

Cited by 6 publications

References 31 publications

The Comparison of Total Phenolics, Total Antioxidant, and Anti-Tyrosinase Activities of Korean Sargassum Species

The Comparison of Total Phenolics, Total Antioxidant, and Anti-Tyrosinase Activities of Korean Sargassum Species

Anti-skin Aging Potential of Sargassum thunbergii Ethanolic Extract: Antioxidant, Anti-inflammatory, and Antiwrinkle Effects on L929 Fibroblast Cells

A cell phone app for facial acne severity assessment

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