Suppression of murine natural killer cell activity by adherent cells from aging mice

Irimajiri, Nobuhiro; Bloom, Eda T.; Makinodan, Takashi

doi:10.1016/s0047-6374(85)80026-9

Cited by 19 publications

(2 citation statements)

References 16 publications

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“…This was indicated by the ability of MGN-3 to significantly increase the activity of P-NK cells that had been depleted of MØ. Earlier studies by Irimajiri at al (1985) suggested that the active adherent suppressor cells, possibly macrophages, are responsible for the suppression of aged murine NK cell activity. We do not know the mechanism by which P-MØ suppress P-NK activity after treatment with MGN-3, but it may involve increased production of H 2 O 2 (Kono et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran)

Ghoneum

Abedi

2004

Journal of Pharmacy and Pharmacology

109

111

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The present study is aimed to examine the possibility of enhancement of natural killer (NK) cell activity in aged C57BL/6 and C3H mice using MGN-3, a modified arabinoxylan from rice bran. Intraperitoneal injection of MGN-3 (10 mg kg(-1) per day) caused a remarkable increase in the peritoneal NK activity as early as 2 days (35.2 lytic units), and the level remained elevated through day 14. The control aged mice had a level of 5.8 lytic units. Enhancement in NK activity was associated with an increase in both the binding capacity of NK cells to tumour targets and in the granular content as measured by BLT-esterase activity. Treatment did not alter the percentage of peritoneal NK cells. Data showed that peritoneal macrophages inhibit NK activity. In conclusion, MGN-3 enhances murine NK activity of aged mice and may be useful for enhancing NK function in aged humans.

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Section: Discussionmentioning

confidence: 99%

Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran)

Ghoneum

Abedi

2004

Journal of Pharmacy and Pharmacology

109

111

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“…BME [ 52 ] and glutathione [ 53 ] also reversed in vitro , the age associated, declines of immune functions of rats. Makinodan, collaborators and others reported that innate immune functions of mice also declined with age; declines postulated to be a consequence of multiple factors that included: the absolute loss of NK cells due to reduced generation in the bone marrow; a decreased capacity of NK cells to bind to target cells; and increased adherent cell suppressor functions [ 54–56 ] – the latter cells differed from those that suppressed antibody synthesis [ 46 , 47 ]. Further, NK functions as well as immune responses of old mice were enhanced by other thiols added to their feed [ 57 , 58 ], including NAC and thioproline (BME was not tested).…”

Section: Bme Alterations Of Immune Functionsmentioning

confidence: 99%

Potential Alteration of COVID-19 by Beta-Mercaptoethanol

Click¹

2020

Future Microbiol.

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Immune System

Miller

1995

Comprehensive Physiology

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The sections in this article are: T Lymphocyte Subsets Helper ( CD 4) and Cytotoxic ( CD 8) T Cell Subsets Naive and Memory T Cell Subsets Other T Cell Subsets T Lymphocyte Function IL ‐2 Production Response to IL ‐2 Production of Other Lymphokines T Cell Activation Clonal Diversify. A “Mosaic” Model for T Cell Senescence T Cell Development Thymic Involution Prothymocyles B Lymphocytes B Cell Number and Subsets Proliferation and Antibody Production Antibodies: Levels, Repertoire, and Autoreactivity B Cell Development Accessory Cells and Their Cytokines Dendritic Cells and Langerhans Cells Cytokine Production Natural Cytotoxicity Restoration of Immune Function Immunity, Disease, and Longevity Summary: Immune Models for Aging Research

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Suppression of murine natural killer cell activity by adherent cells from aging mice

Cited by 19 publications

References 16 publications

Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran)

Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran)

Potential Alteration of COVID-19 by Beta-Mercaptoethanol

Immune System

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