Immune System

Miller, Richard A.

doi:10.1002/cphy.cp110121

Cited by 9 publications

(3 citation statements)

References 267 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 and 2). Reports of age-related changes in the absolute and relative proportions of CD4 and CD8 T cells are less consistent (2) but include numerous reports of declines in peripheral blood CD4 percentages in mice (3)(4)(5) and humans (6,7). The proportion of CD4 and CD8 T cells expressing cell surface P-glycoprotein also increases with age in mice (3,8,9).…”

Section: T Cell Subset Patterns That Predict Resistance Tomentioning

confidence: 99%

T Cell Subset Patterns That Predict Resistance to Spontaneous Lymphoma, Mammary Adenocarcinoma, and Fibrosarcoma in Mice

Miller

Chrisp

2002

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

Aging leads to changes in the proportion of several T cell subsets in peripheral blood, but it is not yet known whether these changes have prognostic significance for late-life diseases. To examine this question, levels of T cell subsets were measured at 8 and 18 mo of age in the peripheral blood of mice of a genetically heterogeneous stock, and the mice were then subsequently evaluated for life span and for cause of death. The results indicate that mice whose T cell subset patterns look like those of old mice tend to die at earlier ages, regardless of the specific cause of death. At 18 mo, 39% of the variance within the set of seven measured subsets could be combined statistically into a single number, whose correlation with individual subsets suggested that it could be interpreted as an index of immunological aging. T cell subset pattern, as represented by this index, was a predictor of life span in mice dying of lymphoma, fibrosarcoma, mammary adenocarcinoma, or of all other causes considered together. Even as early as 8 mo of age, T cell subset patterns are significant predictors of all three forms of cancer, although at this age the association is stronger in mated female mice than in virgin mice. These results support two controversial hypotheses, which are not mutually exclusive: 1) early immune senescence might predispose to early death from cancer and 2) differences in aging rate, as monitored by tests of immune status, might accelerate or decelerate a wide range of late life neoplastic diseases.

show abstract

Section: T Cell Subset Patterns That Predict Resistance Tomentioning

confidence: 99%

T Cell Subset Patterns That Predict Resistance to Spontaneous Lymphoma, Mammary Adenocarcinoma, and Fibrosarcoma in Mice

Miller

Chrisp

2002

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In fact, there have been many studies demonstrating a progressive decrease in the number of T cells with a naive phenotype and a decline in the functions of memory T cells and natural killer (NK) cells [3,4]. A medically relevant deficiency in the immune surveillance system in aged people has been explained by defects in IL-2 production [3], since IL-2 plays an important role in the proliferation and activation of T and NK cells. Thus, analysis of cytokine production is a useful method for studying immune reactions.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, analysis of cytokine production is a useful method for studying immune reactions. Many investigators have reported agerelated changes in production of cytokines in subjects including both genders, although this issue remains controversial [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

Transient Increase in the Levels of T-Helper 1 Cytokines in Postmenopausal Women and the Effects of Hormone Replacement Therapy

Kamada

Irahara²,

Murakami³

et al. 2001

Gynecol Obstet Invest

View full text Add to dashboard Cite

The aim of this study was to determine, at least in part, T-cell function in postmenopausal women and the effects of hormone replacement therapy (HRT). Levels of T-helper 1 (Th1) cytokines (IL-2 and IFN-γ) and T-helper 2 (Th2) cytokines (IL-4 and IL-10) produced by phytohemagglutinin-stimulated whole blood cells from 72 untreated and 44 HRT-treated women were measured by ELISA. Thirteen of the 44 HRT-treated women were examined before and during HRT. The production of IL-2 increased gradually with advance of the postmenopausal period. The levels of IL-2 in women in the early (≤10 years) and mid (>10 and <30 years) postmenopausal stages were significantly higher than those in women in their second, third and fourth decades. The level in women in the late (≧30 years) postmenopausal stage, however, was significantly lower than those in women in the early and mid postmenopausal stages. The level of IFN-γ was highest in women in the mid postmenopausal stage. On the other hand, the levels of Th2 cytokines did not change with age or after menopause until the mid postmenopausal period but were significantly lower in women in the late postmenopausal stage. IFN-γ levels in women on HRT were significantly lower than those in untreated postmenopausal women at all postmenopausal stages. HRT induced a significant decrease in the production of IL-2 and IL-4. In conclusion, production of Th1 cytokines is augmented in women after menopause. HRT prevents this increase, thereby improving the aberration of Th1/Th2 balance that is implicated in an inadequate immune response and pathological conditions.

show abstract

Encephalitis and Schizophrenia

Pearce

2003

Can a Virus Cause Schizophrenia?

View full text Add to dashboard Cite

Immune System

Abstract: The sections in this article are: T Lymphocyte Subsets Helper ( CD 4) and Cytotoxic ( CD 8) T Cell Subsets Naive and Memory T Cell Subsets Other T Cell Subsets T Lymphocyte Function IL … Show more

Cited by 9 publications

References 267 publications

T Cell Subset Patterns That Predict Resistance to Spontaneous Lymphoma, Mammary Adenocarcinoma, and Fibrosarcoma in Mice

T Cell Subset Patterns That Predict Resistance to Spontaneous Lymphoma, Mammary Adenocarcinoma, and Fibrosarcoma in Mice

Transient Increase in the Levels of T-Helper 1 Cytokines in Postmenopausal Women and the Effects of Hormone Replacement Therapy

Encephalitis and Schizophrenia

Contact Info

Product

Resources

About