Suppression of long non-coding RNA MALAT1 inhibits survival and metastasis of esophagus cancer cells by sponging miR-1-3p/CORO1C/TPM3 axis

Li, Qianqian; Dai, Zaiyou; Xia, Chenmei; Jin, Lingxiao; Chen, Xia

doi:10.1007/s11010-020-03759-x

Cited by 25 publications

(19 citation statements)

References 25 publications

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“…Despite the emergence of lncRNAs as critical mediators of various biological processes, mechanistic roles for many lncRNAs in viral infection are still poorly understood. Studies on MALAT1 have shown this lncRNA to be overexpressed in several cancer tissues, associated with high rates of metastasis, and poor prognosis in lung cancer [ 49 ], breast cancer [ 50 ], colon cancer [ 51 ] and esophageal cancer [ 52 ], as well as several other cancer types. MALAT1 has also been implicated in the regulation of histone acetylation [ 53 ], endothelial to mesenchymal transition (EMT) [ 54 ], and cardiac inflammation and dysfunction [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response

Vishnubalaji

Shaath

Alajez

2020

Genes

115

120

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The global spread of COVID-19, caused by pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for an imminent response from medical research communities to better understand this rapidly spreading infection. Employing multiple bioinformatics and computational pipelines on transcriptome data from primary normal human bronchial epithelial cells (NHBE) during SARS-CoV-2 infection revealed activation of several mechanistic networks, including those involved in immunoglobulin G (IgG) and interferon lambda (IFNL) in host cells. Induction of acute inflammatory response and activation of tumor necrosis factor (TNF) was prominent in SARS-CoV-2 infected NHBE cells. Additionally, disease and functional analysis employing ingenuity pathway analysis (IPA) revealed activation of functional categories related to cell death, while those associated with viral infection and replication were suppressed. Several interferon (IFN) responsive gene targets (IRF9, IFIT1, IFIT2, IFIT3, IFITM1, MX1, OAS2, OAS3, IFI44 and IFI44L) were highly upregulated in SARS-CoV-2 infected NBHE cell, implying activation of antiviral IFN innate response. Gene ontology and functional annotation of differently expressed genes in patient lung tissues with COVID-19 revealed activation of antiviral response as the hallmark. Mechanistic network analysis in IPA identified 14 common activated, and 9 common suppressed networks in patient tissue, as well as in the NHBE cell model, suggesting a plausible role for these upstream regulator networks in the pathogenesis of COVID-19. Our data revealed expression of several viral proteins in vitro and in patient-derived tissue, while several host-derived long noncoding RNAs (lncRNAs) were identified. Our data highlights activation of IFN response as the main hallmark associated with SARS-CoV-2 infection in vitro and in human, and identified several differentially expressed lncRNAs during the course of infection, which could serve as disease biomarkers, while their precise role in the host response to SARS-CoV-2 remains to be investigated.

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Section: Discussionmentioning

confidence: 99%

Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response

Vishnubalaji

Shaath

Alajez

2020

Genes

115

120

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“…Esophageal cancer (EC), one of the most common cancers, is ranking eighth in the incidence of all the cancer types and sixth in the causable factors in cancer-related death, and leads a malignancy causing lots of mortality worldwide ( 1 , 2 ). Esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) are known as the two main histological types of EC ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Integrative bioinformatics analysis identifies LINC01614 as a potential prognostic signature in esophageal cancer

Yan¹,

Xu²,

Liu³

et al. 2021

Transl Cancer Res TCR

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Background: Esophageal cancer (EC) is one of the most common gastrointestinal cancers and the incidence is on the increase in recent years. The aim of the present study was to assess novel long non-coding RNA (lncRNA) biomarkers for the prognosis of EC through the analysis of gene expression microarrays.Methods: Three datasets (GSE53622, GSE53624, and GSE53625) were downloaded from the Gene Expression Omnibus (GEO) database and EC patients' clinical information were from The Cancer Genome Atlas (TCGA) databases. Differentially expressed genes (DEGs) were screened by comparing tumor tissues with normal tissues using limma R package. The Gene Expression Profiling Interactive Analysis 2 (GEPIA2) database was used to obtain the novel lncRNAs and their co-expression genes in EC and these were visualized with the Cytoscape software. The Kyoto Encyclopedia of Genes and Genomes (KEGG) Orthology Based Annotation System (KOBAS) database was used to analyze the functions enrichment of selected DEGs. Cell Counting Kit-8 (CCK8) and Transwell assays were used to further confirm the function of target lncRNAs.Results: We identified 24 differentially expressed (DE) lncRNAs and 659 DE mRNAs from the intersection of GEO and TCGA databases. And we found that only LINC01614 was concerned with a candidate prognostic signature in EC. "Extracellular matrix (ECM)-receptor interaction" and "PI3K-Akt signaling pathway" were observed, and we constructed a lncRNA-mRNA co-expression network for EC that includes LINC01614 and 64 mRNAs. The results of CCK8 and Transwell assays showed that suppression of LINC01614 inhibited EC cell proliferation and migration.Conclusions: Our study might provide LINC01614 as a novel lncRNA biomarker for diagnosis and prognosis in EC.

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“…Studies on various malignancies have shown that MALAT1 is associated with miR-1-3p, and inhibition of MALAT1 leads to increased levels of miR-1-3p and, hence, decreased expression of its target gene [ 17 , 20 ]. MALAT1 was shown to plays a role in the proliferation, migration, and invasion of human hilar cholangiocarcinoma (HCCA) cells.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the findings also point out the relation between MALAT1 and miR-1-3p. MALAT1 through acting as miRNA sponges binds to miR-1-3p and prevents its interaction with target mRNAs [ 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

The axis of long non-coding RNA MALAT1/miR-1-3p/CXCR4 is dysregulated in patients with diabetic neuropathy

Ashjari

Karamali

Rajabinejad

et al. 2022

Heliyon

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Suppression of long non-coding RNA MALAT1 inhibits survival and metastasis of esophagus cancer cells by sponging miR-1-3p/CORO1C/TPM3 axis

Cited by 25 publications

References 25 publications

Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response

Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response

Integrative bioinformatics analysis identifies LINC01614 as a potential prognostic signature in esophageal cancer

The axis of long non-coding RNA MALAT1/miR-1-3p/CXCR4 is dysregulated in patients with diabetic neuropathy

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