The axis of long non-coding RNA MALAT1/miR-1-3p/CXCR4 is dysregulated in patients with diabetic neuropathy

Ashjari, Donya; Karamali, Negin; Rajabinejad, Misagh; Hassani, Seyedeh Sara; Hezarkhani, Leila Afshar; Afshari, Daryoush; Karaji, Ali Gorgin; Salari, Farhad; Rezaiemanesh, Alireza

doi:10.1016/j.heliyon.2022.e09178

Cited by 19 publications

(13 citation statements)

References 44 publications

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“…Long coding RNAs (lncRNA) such as MALAT1 and NEAT1 are known to interact with miRNAs and have been implicated in the pathogenesis of DN. 4,5,18 For example, MALAT1 acts as a sponge and binds to miR-1-3p and prevents its interaction with its target. This implies that upregulation of incRNAs may result in downregulation of miRNA as demonstrated in a few studies included in this review.…”

Section: Summary Of Findingsmentioning

confidence: 99%

“…4,5,38 In 4 of 7 studies (57%), DN and DPN were the population of interest. 4,5,27,38 The other 3 studies 16,25,29 included patients with neuropathic pain of various aetiology including diabetes and vascular and inflammatory neuropathies. Although miRNA expression in blood samples were used in 6 of 7 studies, nerve biopsy was used in one study.…”

Section: Description Of the Studies Includedmentioning

confidence: 99%

“…23 Hence, predicting the net functional outcome may be difficult. Despite this difficulty, promising emerging evidence 4,5,38 shows that specific functional roles can be attributed to some miRNAs that may facilitate translational developments. However, identifying and understanding the role of miRNAs in neuropathic pain remains an important step for potentially providing mechanism-based treatment for patients with neuropathic pain in the future.…”

Section: Limitationsmentioning

confidence: 99%

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The role of micro-RNAs in neuropathic pain—a scoping review

Kovanur Sampath,

Belcher,

Hales

et al. 2023

PR9

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Neuropathic pain can be caused by a lesion or disease of the somatosensory system characterised by pathological neuro-immune alterations. At a molecular level, microRNAs (miRNAs) act as regulators of gene expression orchestrating both immune and neuronal processes. Thus, miRNAs may act as essential modulators of processes for the establishment and maintenance of neuropathic pain. The objective/aims of this scoping review was to explore and chart the literature to identify miRNAs that are dysregulated in neuropathic pain. The following databases were searched from inception to March 2023: PubMed, EBSCO, CINAHL, Cochrane Library, and SCOPUS. Two independent reviewers screened, extracted data, and independently assessed the risk of bias in included studies. The JBI critical appraisal checklist was used for critical appraisal. A narrative synthesis was used to summarise the evidence. Seven studies (total of 384 participants) that met our eligibility criteria were included in this scoping review. Our review has identified different miRNAs that are commonly involved in the chronic neuropathic pain conditions including miR-132, miR-101, and miR-199a. Our review findings further suggest that expression of miRNAs to be significantly associated with increased diabetic disease duration, HbA1C levels, and fibrinogen levels. Our review findings suggest that there is clear association between miRNA expression and chronic neuropathic pain conditions. Therefore, increasing the specificity by selecting a candidate miRNA and identifying its target mRNA is an area of future research.

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Section: Summary Of Findingsmentioning

confidence: 99%

Section: Description Of the Studies Includedmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

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The role of micro-RNAs in neuropathic pain—a scoping review

Kovanur Sampath,

Belcher,

Hales

et al. 2023

PR9

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“…LncRNA MALAT1 was significantly upregulated in the peripheral-blood mononuclear cells of patients with diabetic neuropathy [ 77 ]. Further, a significant positive association between MALAT1 and C-X-C motif chemokine receptor 4 (CXCR4) was observed.…”

Section: Dysregulated Human Ncrnas In Diabetesmentioning

confidence: 99%

Current Insights into miRNA and lncRNA Dysregulation in Diabetes: Signal Transduction, Clinical Trials and Biomarker Discovery

Pandey¹,

Ajgaonkar²,

Jadhav³

et al. 2022

Pharmaceuticals

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Diabetes is one of the most frequently occurring metabolic disorders, affecting almost one tenth of the global population. Despite advances in antihyperglycemic therapeutics, the management of diabetes is limited due to its complexity and associated comorbidities, including diabetic neuropathy, diabetic nephropathy and diabetic retinopathy. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are involved in the regulation of gene expression as well as various disease pathways in humans. Several ncRNAs are dysregulated in diabetes and are responsible for modulating the expression of various genes that contribute to the ‘symptom complex’ in diabetes. We review various miRNAs and lncRNAs implicated in diabetes and delineate ncRNA biological networks as well as key ncRNA targets in diabetes. Further, we discuss the spatial regulation of ncRNAs and their role(s) as prognostic markers in diabetes. We also shed light on the molecular mechanisms of signal transduction with diabetes-associated ncRNAs and ncRNA-mediated epigenetic events. Lastly, we summarize clinical trials on diabetes-associated ncRNAs and discuss the functional relevance of the dysregulated ncRNA interactome in diabetes. This knowledge will facilitate the identification of putative biomarkers for the therapeutic management of diabetes and its comorbidities. Taken together, the elucidation of the architecture of signature ncRNA regulatory networks in diabetes may enable the identification of novel biomarkers in the discovery pipeline for diabetes, which may lead to better management of this metabolic disorder.

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“… 54 A similar result was observed for lncRNA‐GM4419 in renal tissue from T2D nephropathy mice and HG‐induced mesangial cells. 33 In addition, MALAT1 34 , 35 and SNHG5 36 were shown to regulate inflammation by targeting NLRP3 in T2D brain tissue or neuron cells, and SNHG2 55 , 56 was reported to modulate inflammation by regulating NF‐κB, while H19 37 and lnc uc.48 38 regulate inflammation by activating endoplasmic reticulum stress proteins (XBP1 or ERK), indicating that inflammatory responses are differentially regulated by lncRNAs. In addition, some lncRNAs regulate inflammation by epigenetic modification of inflammation‐related genes.…”

Section: Roles Of Lncrnas In Diabetesmentioning

confidence: 99%

Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes

Chang

Wang

Zhang

et al. 2022

Traffic

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The prevalence of a high-energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The pathological mechanism of this disease is not fully clear. Accumulated evidence has shown that noncoding RNAs have an essential regulatory role in the progression of diabetes and its complications. The roles of small noncoding RNAs, such as miRNAs, in T2D, have been extensively investigated, while the function of long noncoding RNAs (lncRNAs) in T2D has been unstudied. It has been reported that lncRNAs in T2D play roles in the regulation of pancreatic function, peripheral glucose homeostasis and vascular inflammation. In addition, lncRNAs carried by small extracellular vesicles (sEV) were shown to mediate communication between organs and participate in diabetes progression. Some sEV lncRNAs derived from stem cells are being developed as potential therapeutic agents for diabetic complications. In this review, we summarize the current knowledge relating to lncRNA biogenesis, the mechanisms of lncRNA sorting into sEV and the regulatory roles of lncRNAs and sEV lncRNAs in diabetes. Knowledge of lncRNAs and sEV lncRNAs in diabetes will aid in the development of new therapeutic drugs for T2D in the future.

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The axis of long non-coding RNA MALAT1/miR-1-3p/CXCR4 is dysregulated in patients with diabetic neuropathy

Cited by 19 publications

References 44 publications

The role of micro-RNAs in neuropathic pain—a scoping review

The role of micro-RNAs in neuropathic pain—a scoping review

Current Insights into miRNA and lncRNA Dysregulation in Diabetes: Signal Transduction, Clinical Trials and Biomarker Discovery

Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes

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