Suppression of guinea pig ileum induced contractility by plasma albumin of hibernators

Bruce, David S.; Ambler, Douglas L.; Henschel, Timothy M.; Oeltgen, Peter R.; Nilekani, Sita P.; Amstrup, Steven C.

doi:10.1016/0091-3057(92)90658-3

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…The effect of cross‐species suppression of muscle force has previously been reported: plasma from torpid black bears and denning polar bears will suppress guinea pig ileum (smooth muscle) contractility 5–7. Our results support the notion that exposure of swine skeletal muscle to HIT from a hibernating animal also induces such force suppression along with ischemia protection (Fig.…”

Section: Discussionsupporting

confidence: 87%

“…Importantly, when the responses in the SAWP group were compared to the overall force recoveries in controls, no differences were observed. Consistent with this finding, Bruce et al studied dynamic changes in levels of HIT from the albumin fraction of plasma in the black bear, and investigated the suppression degrees of the guinea pig ileum contraction with three different states (summer active, winter active, and winter hibernating) of the albumin fraction along with [D‐Pen2, 5]‐enkephalin (DPDPE, an opioid binding to the delta receptor subtype); they reported that δ‐opioid agonist production increased only during the hibernation season 6, 7. Furthermore, during hibernation, profound metabolic changes such as respiratory depression, mild hypothermia, and hypophagia have been reported to occur 4.…”

Section: Discussionmentioning

confidence: 99%

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Hibernation induction trigger reduces hypoxic damage of swine skeletal muscle

et al. 2005

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A link between the cardioprotective benefits of pharmacological preconditioning and natural mammalian hibernation is considered to involve the cellular activation of opioid receptors and subsequent opening of K(ATP) channels. In previous studies, we have demonstrated the protective effects of specific delta-opioid agonists against porcine cardiac ischemia/reperfusion injury. We hypothesize here that preincubation with hibernation induction trigger (HIT) should confer a similar protection in skeletal muscles. Therefore, muscle bundles from swine were pretreated with plasma from hibernating woodchucks (HWP) for 30 min, then exposed to hypoxia for 90 min and reoxygenation for 120 min. Stimulated twitch forces were assessed. The functional effects of pretreatment with nonhibernation (summer) woodchuck plasma, a K(ATP) blocker, or opioid antagonist were also studied. During the reoxygenation period, significantly greater force recoveries were observed only for bundles pretreated with HWP; this response was blocked by naloxone (P < 0.05). We conclude that HIT pretreatment could be used to confer protection against hypoxia/reperfusion injury of skeletal muscles of nonhibernators; it could potentially be utilized to prevent injury during surgical procedures requiring ischemia.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Hibernation induction trigger reduces hypoxic damage of swine skeletal muscle

et al. 2005

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“…Subsequently, plasma albumin fraction from hibernating animals (TLS, WC, black bear, or polar bear, Ursus maritimus) was shown to inhibit guinea pig ileum muscle strip contractility and this was partially reversed with naloxone [59]. Other studies of plasma albumin fraction from hibernating animals claiming δ-opioid activity failed to confirm such activity by reversing effects of depressed guinea pig ileum or mouse vas deferens contractility with δ-opioid receptor antagonists or by displacing [ 3 H] DADLE binding [60][61][62][63].…”

Section: The Search For a "Hibernation Induction Trigger" Leads Tmentioning

confidence: 98%

Potential for Discovery of Neuroprotective Factors in Serum and Tissue from Hibernating Species

Ross¹,

Drew²

2006

MRMC

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“…The guinea pig ileum longitudinal musclemyenteric plexus (GPI) is an effective test for general opioid activity; addition of opioids suppress electrically stimulated contractions (Bruce et al, 1997a). Application of plasma from a range of torpid hibernating animals successfully suppresses contractions of the GPI (Bruce et al, 1992;Bruce et al, 1997a;Bruce et al, 1996;Bruce et al, 1987a;Bruce et al, 1987b;Oeltgen et al, 1987). Plasma from metabolically depressed hibernators also suppresses contractions of the mouse vas deferens (MVD), an assay specific for delta-opioid activity, suggesting that HIT may be opioidlike in nature and acts via the delta-opioid receptors (Bruce et al, 1997b;Horton et al, 1998).…”

Section: Regulation Of Metabolic Depressionmentioning

confidence: 99%

Metabolic depression in Cyclorana alboguttata and the potential role of the endogenous opioid system and thyroid axis as regulators of aestivation

Kayes¹

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This thesis is composed of my original work, and contains no material previously published or written by another person except where due reference has been made in the text. I have clearly stated the contribution by others to jointly-authored works that I have included in my thesis.I have clearly stated the contribution of others to my thesis as a whole, including statistical assistance, survey design, data analysis, significant technical procedures, professional editorial advice, and any other original research work used or reported in my thesis. The content of my thesis is the result of work I have carried out since the commencement of my research higher degree candidature and does not include a substantial part of work that has been submitted to qualify for the award of any other degree or diploma in any university or other tertiary institution. I have clearly stated which parts of my thesis, if any, have been submitted to qualify for another award. I acknowledge that an electronic copy of my thesis must be lodged with the University Library and, subject to the General Award Rules of The University of Queensland, immediately made available for research and study in accordance with the Copyright Act 1968. I acknowledge that copyright of all material contained in my thesis resides with the copyright holder(s) of that material.

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Suppression of guinea pig ileum induced contractility by plasma albumin of hibernators

Cited by 8 publications

References 17 publications

Hibernation induction trigger reduces hypoxic damage of swine skeletal muscle

Hibernation induction trigger reduces hypoxic damage of swine skeletal muscle

Potential for Discovery of Neuroprotective Factors in Serum and Tissue from Hibernating Species

Metabolic depression in Cyclorana alboguttata and the potential role of the endogenous opioid system and thyroid axis as regulators of aestivation

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