Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption

Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences

“…For example, the ethanol preferring phenotype is related to differences in emotionality (e.g. open field defecation, vocalization) and pain sensitivity (Badistov et al 1995;Kampov-Polevoy et al 1995b;Overstreet et al 1997). Factors that control ethanol and cocaine-maintained behavior in rats also control excessive running (Werme et al 1999(Werme et al , 2000.…”

“…The activity and consummatory behaviors and elevated drug self-administration, have been linked to mesolimbic dopaminergic (Piazza et al 1991a(Piazza et al , 1991bCarr and Kutchukidze 2000) and opioid (Werme et al 2000;Lett et al 2001;Zhang and Kelley 2002) mechanisms. Concordant findings from human studies illustrate the correlative effects of alcohol and drug abuse and activity (Alessi et al 2000) as well as taste sensitivity and avidity for sweets (Morabia et al 1989;Willenbring et al 1989;Yamamoto et al 1991;Pelchat and Danowski 1992;Kampov-Polevoy et al 1995a, 1995b, 1999Hirsch 1997;Carroll 1999).…”

Effects of alcohol and saccharin deprivations on concurrent ethanol and saccharin operant self-administration by alcohol-preferring (P) rats

“…Availability of sweet substances has been shown to have an impact on the relative preference for ethanol in Fawn-hooded rats, which demonstrate an initial decrease in EtOH drinking behavior following the introduction of 0.1% saccharin (Kampov-Polevoy et al, 1995). Studies offering concurrent availability of sweetened water or a chocolate-flavored drink have shown a marked decrease in intake of EtOH, including the high-alcohol-drinking (HAD) rats (Lankford and Myers, 1994) and Sardinian alcohol-preferring (sP) rats (Colombo et al, 1997).…”

Goal- and signal-directed incentive: conditioned approach, seeking, and consumption established with unsweetened alcohol in rats

“…Pavlovian conditioning followed this training and also used the same unsweetened ethanol reinforcer. Although experience with sweet solutions may influence later alcohol preference (Kampov-Polevoy et al 1995), both operant responding and cue associations were based on ethanol reinforcement.…”