1986
DOI: 10.1001/archotol.1986.03780110061008
|View full text |Cite
|
Sign up to set email alerts
|

Suppression of Cellular Immunity by Head and Neck Irradiation: Precipitating Factors and Reparative Mechanisms in an Experimental Model

Abstract: \s=b\A model was developed in C3H mice to investigate the immunosuppressive effects of head and neck irradiation and to explore mechanisms for repair of the defects. Mice receiving 1200 rad (12 Gy) of head and neck irradiation showed significant depression of delayed-type hypersensitivity, peripheral blood lymphocyte counts, spleen cell counts, and spleen cell production of interleukin-2. Treatment with optimal dosages of thymosin alpha, (T\g=a\-1)produced significant increases in all of these values, in some … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

1
0
0

Year Published

1987
1987
2009
2009

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 13 publications
(1 citation statement)
references
References 35 publications
1
0
0
Order By: Relevance
“…45,46 But even irradiation of the limited anatomical areas such as neck can cause lymphopenia lasting over 2 years, especially regarding some subpopulations of T lymphocytes. 44,47,48 Also in our study, RT almost halved the levels of lymphocytes. With RT, vertebrae are mostly spared from irradiation; also, the thymus is not in the radiation field and most of the neck nodes are removed at the time of operation.…”
Section: Discussionsupporting
confidence: 76%
“…45,46 But even irradiation of the limited anatomical areas such as neck can cause lymphopenia lasting over 2 years, especially regarding some subpopulations of T lymphocytes. 44,47,48 Also in our study, RT almost halved the levels of lymphocytes. With RT, vertebrae are mostly spared from irradiation; also, the thymus is not in the radiation field and most of the neck nodes are removed at the time of operation.…”
Section: Discussionsupporting
confidence: 76%