Alterations in T-Lymphocyte Subpopulations in Patients With Head and Neck Cancer: Correlations With Prognosis

Wolf, Gregory T.; Schmaltz, Stephen; Hudson, Jack W.; Robson, Harriet; Stackhouse, Thomas; Peterson, Karen A.; Poore, Judy; McClatchey, Kenneth D.

doi:10.1001/archotol.1987.01860110066010

Cited by 56 publications

(45 citation statements)

References 31 publications

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“…This observation suggests that the disease process has a profound and long-lasting impact on T lymphocyte homeostasis in patients with SCCHN. Others have suggested previously that lymphocyte counts have prognostic value in SCCHN (22).…”

Section: Discussionmentioning

confidence: 96%

Decreased Absolute Counts of T Lymphocyte Subsets and Their Relation to Disease in Squamous Cell Carcinoma of the Head and Neck

Kuss

Hathaway

Ferris

et al. 2004

Clinical Cancer Research

237

202

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Results: Patients with SCCHN had significantly lower absolute numbers of CD3؉ CD4؉, and CD8؉ T cells than normal controls. However, no differences in the percentages of T-cell subsets between patients and normal controls were observed. Patients with active disease had significantly lower CD3؉ and CD4؉ T-cell counts than those with NED. Patients who had NED after surgery and radiotherapy had the lowest T-cell counts among the NED cohort. Patients who had NED for >2 years did not recover their T-cell counts, and the T-cell imbalance was evident many years after curative surgery. The tumor-node-metastasis (TNM) stage or site of the disease was not related to the absolute T-cell count. Patients with recurrent disease at the time of blood draw tended to have the lowest CD4؉ T-cell counts. Conclusions:Patients with SCCHN have altered lymphocyte homeostasis, which persists for months or years after curative therapies.

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Section: Discussionmentioning

confidence: 96%

Decreased Absolute Counts of T Lymphocyte Subsets and Their Relation to Disease in Squamous Cell Carcinoma of the Head and Neck

Kuss

Hathaway

Ferris

et al. 2004

Clinical Cancer Research

237

202

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“…Quantitative alterations of lymphocyte populations at the systemic level have been correlated with a poorer prognosis in patients with head and neck squamous cell carcinoma. 19 Functional change of the immune system, such as lymph node reactivity, can be a prognostic factor for patients with laryngeal squamous cell carcinoma. 20 Lymphocyte function may reflect that the serum of cancer patients also can be changed in the presence of cancer.…”

Section: Discussionmentioning

confidence: 99%

Telomerase Activity of Peripheral Blood Mononuclear Cells From Patients With Laryngeal Carcinoma

Zhang

et al. 2004

American Journal of Clinical Oncology

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This study investigated the activity of telomerase in peripheral blood mononuclear cells (PBMCs) in patients with laryngeal carcinoma. We examined proliferative response to phytohemagglutinin and expression of telomerase activity of PBMCs from 30 patients with laryngeal carcinoma and 17 healthy volunteers. Both proliferative and telomerase activity of [circled times]PBMCs in the patient group was lower than that in the healthy volunteer group. Telomerase activity may play a permissive role in cell division and clonal expansion of the immune cells in response to laryngeal squamous carcinoma. It may be related to lymph node metastasis of laryngeal cancer.

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“…Auch über veränderte Zusammensetzung der Lymphozyten des peripheren Blutes wurde mehrmals berichtet [2,20]. Die Angaben dazu sind teilweise erheblich divergent, was in unterschiedlichen Untersuchungsmethoden oder verwendeten Antikörpern begründet sein kann.…”

Section: Lymphozyten Des Peripheren Blutesunclassified

“…In einer Untersuchung über HNO-Karzinompatienten [20] besaßen 7-41 Monate nach Therapie die symptomfreien Patienten deutlich, aber nicht signifikant mehr NK-Zellen im peripheren Blut verglichen mit Rezidivpatienten. Dies entspricht unseren Ergebnissen hinsichtlich der Qualität der Aussage, nicht aber der Quantität.…”

Section: Nk-zellenunclassified

Ver�nderungen von peripheren Blutzellpopulationen bei HNO-Karzinompatienten

Ostwald

Dommerich

Schulz

et al. 2004

HNO

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Alterations in T-Lymphocyte Subpopulations in Patients With Head and Neck Cancer: Correlations With Prognosis

Cited by 56 publications

References 31 publications

Decreased Absolute Counts of T Lymphocyte Subsets and Their Relation to Disease in Squamous Cell Carcinoma of the Head and Neck

Decreased Absolute Counts of T Lymphocyte Subsets and Their Relation to Disease in Squamous Cell Carcinoma of the Head and Neck

Telomerase Activity of Peripheral Blood Mononuclear Cells From Patients With Laryngeal Carcinoma

Ver�nderungen von peripheren Blutzellpopulationen bei HNO-Karzinompatienten

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