Suppression of Adjuvant Arthritis in Rats by Cholesterol

Abstract

Abstract-Dietary cholesterol suppressed adjuvant arthritis, a chronic inflammatory disease, in rats, but did not significantly affect carrageenin edema, an acute inflammation.When rats were fed a high-cholesterol diet beginning 10 days before injection of adjuvant, the development of the adjuvant-induced arthritis was greatly suppressed.Cholesterol feeding prevented hypertrophy of the adrenal gland in arthritic rats, but had little influence on the serum corticosterone level. A sig nificant positive correlation was observed between the adrenal weight and the severity of the arthritis.These findings suggest that the effect of cholesterol feeding is not due to increased adrenal sterol synthesis.Dietary cholesterol also prevented hypertrophy of the spleen, but had no effect on atrophy of the thymus in adjuvant treated rats. Cholesterol-fed rats showed a significant decrease in the serum lipid peroxide level and a significant increase in the serum copper level. Adjuvant treatment not only enhanced hypercholesterolemia produced by cholesterol feeding, but also the level of free cholesterol in serum. These results suggest that dietary cholesterol may exert some effect on the immune response through changes in spleen and liver functions.

Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

“…A mild dyslipidemia with increased levels of TC, TG, LDL cholesterol, VLDL cholesterol and lower levels of HDL cholesterol is evidenced in RA patients when compared to healthy controls and is in par with our present study . Altered hepatic function, a chief feature of RA, might cause alteration in lipid metabolism as lipids are of hepatic origin . In our present study, the lipid metabolic changes observed in arthritic rats were regulated to near normal levels by trikatu treatment.…”

Anti-Inflammatory Activity ofCleome gynandraL. on Hematological and Cellular Constituents in Adjuvant-Induced Arthritic Rats

“…It has been reported that lipid metabolism was affected during the arthritic condition, which shows the biphasic changes in lipid level. 41 Nucleic acids were not altered significantly in arthritic animals. The decreased level of glycogen may be due to enhanced glycogenolytic activity of liver during arthritis.…”

Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis

“…It is, therefore, expected that the adult population could be already primed for an antiHsp65 response that could affect an ensuing response to DNA-HSP65 vaccination. In addition, hypercholesterolemia has been associated with a modulatory activity on immune functions (17,18). A preferential differentiation towards a strong Th2 phenotype was previously described (19) and recently confirmed in the presence of an extreme hypercholesterolemic condition (20).…”