Supported N-propylsulfamic acid on magnetic nanoparticles used as recoverable and recyclable catalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in water

Synthesis and characterization of glucosulfonic acid supported on Fe3O4 nanoparticles as a novel and magnetically recoverable nanocatalyst and its application in the synthesis of polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives

“…One of the most promising MNPs supports for the development of high performance catalyst supports is superparamagnetic iron oxide [9]. The notable advantages of Fe 3 O 4 NPs are simple synthesis, readily available, low cost, high surface area, low toxicity, operation simplicity and much easier and more effective separation than filtration or centrifugation [10]. Therefore, Fe 3 O 4 NPs are considered as ideal supports for the heterogenization of homogeneous catalysts [11].…”

“…In recent years Impressive efforts was made in the development of new catalytic systems which are immobilized onto Fe 3 O 4 [19][20][21][22][23][24][25]. Polyhydroquinoline and 2,3-Dihydroquinazolinone derivatives are very well-known including six membered heterocyclic ring molecules that have been reported to possess a wide range of biological properties and pharmaceutical activities [9,10]. Polyhydroquinoline (PHQ) derivatives contain a large family of medicinally important compounds that have attracted much attention because of their diverse pharmacological and therapeutic properties, such as vasodilator, hepatoprotective, antiatherosclerotic, bronchodilator, antitumor, geroprotective, antidiabetic activity and also their ability to modulate calcium channels [26,27].…”

“…Thus the synthesis of these heterocyclics has become an area of great interest. Also, 2,3-Dihydro-4(1H)quinazolinones are important bicyclic heterocycles which have emerged as versatile biologically active compounds possessing applications as diuretic, vasodilating, tranquilizing, antitumor, antidefibrillatory, antibiotic, antihistaminic, anticonvulsant, anticancer, herbicidal activity, plant growth regulation ability and antihypertensive agents [4,10,28]. They are also reported to possess the ability to inhibit enzymes of biological importance [29].…”

“…They are also reported to possess the ability to inhibit enzymes of biological importance [29]. In addition, these compounds can be easily oxidized to their quinazolin-4(3H)-one analogues [10], which also include important pharmacologically active compounds, Generally, 2,3dihydroquinazolin-4(1H)-ones were prepared using the reductive cyclization of aldehydes or ketones with 2aminobenzamide in the presence of acid catalysts [9,29]. For these reasons, many methods have been developed including microwave and ultrasound irradiation techniques using various catalytic systems [26][27][28][29].…”

Synthesis, characterization, and catalytic application of Fe3O4‐Si‐[CH2]3‐N=CH‐aryl for the efficient synthesis of novel poly‐substituted pyridines

“…Furthermore, functionalized MNPs are a suitable replacement for the conventional homogeneous and heterogeneous catalysts that are used in the industry and organic reactions . Their good catalytic activities are due to their ability to join different functional groups, their magnetism, their thermal stability, and their strong inorganic layer …”