Synthesis, characterization, and catalytic application of Fe₃O₄‐Si‐[CH₂]₃‐N=CH‐aryl for the efficient synthesis of novel poly‐substituted pyridines

Abstract

Fe3O4 magnetic nanoparticles (MNPs) were functionalized by aminopropylsilane and reacted with aromatic aldehyde, and Fe3O4‐Si‐[CH2]3‐N=CH‐Aryl and Fe3O4‐Si‐(CH2)3‐NH‐CH2‐Aryl MNPs were prepared as novel magnetic nanocatalysts. Fourier transform infrared (FT‐IR), X‐ray diffraction (XRD), and scanning and transmission electron microscopy (SEM and TEM) were used to identify the MNPs. The catalytic activity of the MNPs was evaluated in the one‐pot synthesis of some novel poly‐substituted pyridine derivatives.

Recent Advances in Pyridine Scaffold: Focus on Chemistry, Synthesis, and Antibacterial Activities

“…Similarly, MNPs 13 [ 34 ] or CoFe 2 O 4 @SiO 2 MNPs ( 14 ) [ 35 ] catalysts were successfully employed for the synthesis of 17 via MCRs. In each case, 17 was obtained with good to high yields in a short reaction time.…”

Magnetically recoverable catalysts for the preparation of pyridine derivatives: an overview

“…Nano-magnetic Fe 3 O 4 –Si–(CH 2 ) 3 –N CH–Ph–OMe MNPs 29 was prepared by the reaction of Fe·Cl 3 ·6H 2 O 24, FeCl 2 ·4H 2 O 25, and NH 4 OH 26 in H 2 O under N 2 atmosphere to prepare Fe 3 O 4 MNPs 1, which was functionalized with aminopropyl silane 5 to provide Fe 3 O 4 –Si–[CH 2 ] 3 –NH 2 27, followed by modification with 4-methoxy benzaldehyde 28 under reflux conditions in ethanol for 24 h ( Scheme 7 ). 36 …”

“…Fe 3 O 4 –Si–(CH 2 ) 3 –N CH–Ph–OMe MNPs 29 was used in the synthesis of 2-amino-3-cyanopyridines 23 via the multicomponent reaction of various aromatic aldehydes 9, 2-acetylnaphthalene 31, or deoxybenzoin 31, malononitrile 16, and ammonium acetate 10 under solvent-free conditions at 120 °C for 40–70 min in good to high yield in short times ( Scheme 8 ). 36 …”