Supplementation of the sow diet with chitosan oligosaccharide during late gestation and lactation affects hepatic gluconeogenesis of suckling piglets

Xie, Changqing; Guo, Xiaoyun; Long, Cimin; Fan, Zhiyong; Xiao, Dingfu; Ruan, Zheng; Deng, Zeyuan; Wu, Xin; Yin, Yulong

doi:10.1016/j.anireprosci.2015.06.004

Cited by 34 publications

(18 citation statements)

References 61 publications

(63 reference statements)

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“…Studies have shown that COS possesses multiple functional properties, including anti-oxidation (Fernandes et al 2010), anti-inflammation (Lee et al 2009) and immune-enhancing characteristics (Okamoto et al 2003). Researches have also revealed that COS can be used as a substitute to antibiotics and confer marked health benefits in animals (Yang et al 2012;Xie et al 2015;Suthongsa et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Maternal chitosan oligosaccharide supplementation during late gestation and lactation affects offspring growth

Wan

2018

Italian Journal of Animal Science

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Chitosan oligosaccharide (COS), a natural compound derived from chitin, has growth promotion property. However, the nature of the relationship between maternal COS supplementation and offspring growth is not yet understood. Therefore, we intended to determine the effects of maternal COS supplementation in late gestation and lactation on the offspring growth performance. Twenty-four pregnant Yorkshire sows were distributed into two equal groups (n ¼ 12) and fed either with a basal diet (control group) or a basal diet containing 100 mg/kg COS, from gestation day 85 until lactation day 21. Serum samples were collected from six sows of average body weight, from each group on farrowing day (lactation day 1) and lactation day 21, whereas colostrum and milk samples were respectively obtained on lactation days 1 and 21. We found that maternal COS supplementation significantly increased (p < .05) the average piglet weaning weight per litter. Supplementation of COS in the sow diet elevated (p < .05) the serum interleukin-10, immunoglobulin A (IgA) and IgM concentrations, as well as total antioxidant capacity. Moreover, higher (p < .05) colostrum IgM and milk lactose contents were simultaneously observed in COS-treated sows compared to the control sows. In summary, COS supplementation during late gestation and lactation can boost antioxidant capacity and humoural immunity of sows, and contributes to improving colostrum and milk quality, ultimately, enhancing the offspring growth performance. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Maternal chitosan oligosaccharide supplementation during late gestation and lactation affects offspring growth

Wan

2018

Italian Journal of Animal Science

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“…Our previous study has found that maternal COS supplement increased birth weight and growth rate of piglets [12], and postpartum upregulates cholesterol accumulation in suckling piglets [13]. Therefore, we hypothesised that supplementation with COS in sow diets could affect the function of the placenta.…”

Section: Introductionmentioning

confidence: 99%

Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

Xie

Long

et al. 2016

BMC Vet Res

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BackgroundChitosan oligosaccharide (COS) is widely consumed as a functional food due to its multiple health effects, but few studies about COS supplement on placental antioxidant and nutrition transport capacity were reported. Taken pregnant sow as a model, we aimed to investigate the effects of dietary COS supplementation during late gestation on placental amino acids transport and antioxidant defense capacity of sows. From day (d) 85 of gestation to parturition, sixteen pregnant sows were divided into a control group (basal diet without COS supplementation) and a COS group (30 mg COS/kg basal diet). Plasma sample of sow was collected on d 110 of gestation, and placenta tissue was obtained during parturition. Then plasma antioxidant enzyme’s activities, the relative level of oxidant stress related genes, amino acids transport related genes and mTOR pathway molecules in placenta were determined.ResultsResults showed that maternal dietary supplementation with COS increased (P < 0.05) plasma total SOD, caused a downtrend in plasma MDA (0.05 < P < 0.10) on d 110 of gestation. Interestingly, the mRNA expression of some antioxidant genes in the placenta were increased (P < 0.05) and pro-inflammatory cytokines were reduced (P < 0.05) by COS supplement, whereas no significant difference was observed in the activities of placental total SOD and CAT between two groups. Additionally, further study demonstrated that COS feeding stimulated mTOR signaling pathway, increased amino acids transporters expression in placenta.ConclusionsThese observations suggested that COS supplement in sow’s diet during late gestation enhanced antioxidant defense capacity of sows, promoted placental amino acids transport, which may contribute to the health of sows and development of fetus during gestation.

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“…Sows were fed 2.5–3.0 kg d −1 from day 80 to day 107 of pregnancy, 1.8 kg d −1 from day 107 to delivery and 1.0–1.5 kg d −1 on the day of delivery. Single‐column feeding was used in this study, with the feeder being cleaned after every meal to ensure the daily freshness of feed . Disease and health management was consistent across the farm.…”

Section: Methodsmentioning

confidence: 99%

Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles

Gao

Liu

et al. 2020

J Sci Food Agric

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BACKGROUND Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on the immune function of the small intestine in neonatal and suckling piglets. RESULTS Results showed that compared to the control group, maternal dietary UR supplementation significantly decreased incidence of diarrhea in suckling piglets (P < 0.01); and increased both duodenal and ileal average villus height (P < 0.01) as well as villus height/crypt depth in ileum (P = 0.017) in neonatal piglets. RT‐qPCR results showed that maternal UR supplementation decreased mRNA expression of claudin‐1 in jejunum and ileum of neonatal piglets (P < 0.05), while significantly increased mRNA expression of claudin‐1 in duodenum and jejunum of suckling piglets. Furthermore, in suckling piglets, maternal dietary UR supplementation increased mRNA expression of IL‐6, IL‐8 and IL‐1β in duodenum, jejunum and ileum (P < 0.05), increased IL‐10 expression in both jejunal and ileal mucosa (P < 0.05) and increased mRNA expression of IKB and TLR4 in ileal mucosa (P < 0.05). CONCLUSIONS These results suggest that maternal dietary supplementation with UR contributed to reducing incidence of diarrhea by regulating cytokine secretion and intestinal mucosal barrier function in suckling piglets. © 2020 Society of Chemical Industry

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Supplementation of the sow diet with chitosan oligosaccharide during late gestation and lactation affects hepatic gluconeogenesis of suckling piglets

Cited by 34 publications

References 61 publications

Maternal chitosan oligosaccharide supplementation during late gestation and lactation affects offspring growth

Maternal chitosan oligosaccharide supplementation during late gestation and lactation affects offspring growth

Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles

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