Supplementation of selenium reduces chemical hepatocarcinogenesis in male Sprague-Dawley rats

Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice

“…Preneoplastic and neoplastic lesions in rat liver were reduced on supplementation of diet with sodium selenite (5 g/ml/100 g) for periods ranging from 1 day to several weeks [50]. Alwahaibi et al observed that sodium selenite (4 mg/kg) could avert hepatocellular carcinoma by an antioxidant action and improve DNA repair [51].…”

A Multi-Mineral Natural Product Inhibits Liver Tumor Formation in C57BL/6 Mice

“…Previous short-term (6 week) studies demonstrated that including high levels of chromium (to provide up to 80 μg/kg of body weight) in the diet reduced liver injury in chronic cholestasis [35] as well as liver injury occurring in diabetic mice [36]. In another short-term study, sodium selenite (4 mg/kg of diet) reduced carcinogen-induced liver tumors in rats [37]. Mechanisms of action were not clearly delineated in these studies as multiple histo-pathological and biochemical changes were seen.…”

The Effect of Sulfamethoxazole and Selenium on Antioxidant Defense System in the Blood of Rats Treated With DEN

“…These selenoproteins include glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), which have important antioxidant and detoxification functions 19 . Mechanisms for anticancer action of selenium are not fully understood; however, several theories have been proposed, the important ones being antioxidant protection, enhanced carcinogen detoxification, enhanced immune surveillance, modulation of cell proliferation (cell cycle and apoptosis), inhibition of tumor cell invasion, and inhibition of angiogenesis 20,21 .…”

“…Animals were caged in group of six under controlled conditions of temperature The doses of DEN, sulphamethoxazole and sodium selenium were selected as per the model reported by Ghosh A.S., 22 Lawrence D. Mayer et al 23 and Alwahaidi et al 21 respectively.…”