Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice

Banji, David; Banji, Otilia J.F.; Reddy, M. V. B.; Annamalai, A.R.

doi:10.1016/j.jtemb.2013.01.001

Cited by 15 publications

(8 citation statements)

References 46 publications

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“…Marques et al (2002) suggested that CAP can induce sister chromatid exchange, and micronuclei formation. The alkyl moiety in CAP caused DNA methylation (Jones and Buckley 1990;Jones 1984) and led to alteration in the structure of cellular DNA (Banji et al 2013). These findings suggest that the comet assay is a highly sensitive technique to study DNA damage caused by CAP.…”

Section: Discussionmentioning

confidence: 97%

“…Pepper fruits (Capsicum annuum L.) are important vegetables used as vegetable food and as spices with well-known antioxidant properties (Rice et al, Rice-Evans et al 1997). Capsaicin (CAP) (trans-8-methyl-N-vannilyl-6-nonemide) is the major pungent principle found in hot red and chili peppers of the plant genus Capsicum that has long been used as spices, food additives and drugs (Cordell and Araiyo 1993;Sharma et al 2013) and is extensively consumed as a condiment in Asian, African and Latin American countries (Banji et al 2013). It is employed as a condiment and colorant in the cosmetic and pharmaceutical industries (Banji et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…CAP readily evokes the formation of micronuclei and promotes sister chromatid exchange in mice (Diaz Barriga-Areos et al 1995;Lee and Cho 1997). Excessive and frequent consumption of capsicum leads to organic disturbances in the digestive tract (Sanghvi 1981) characterized by duodenal (Toth and Gannett 1992) and gastric tumors (Agarwal et al 1986;Banji et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of (−)-epigallocatechin-3-gallate on capsaicin-induced DNA damage and oxidative stress in human erythrocyes and leucocytes in vitro

Pandır

2014

Cytotechnology

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The aim of this study is to show that protective effects of the main catechin (-)-epigallocatechin-3-gallate (EGCG) against capsaicin (CAP) induced oxidative stress and DNA damage in human blood in vitro. Superoxide dismutase, catalase, glutathione peroxidase and malondialdehyde (MDA) level were studied in erythrocytes and leucocytes with increased concentrations of CAP. DNA damage in leucocytes was measured by the comet assay. Human blood cells have been administered with doses between 0 and 200 μM of CAP and/or EGCG (20 μM) for an hour at 37 °C. Treatment with CAP alone has increased the levels of MDA and decreased antioxidant enzymes in human blood cells. A significant increase in tail DNA%, mean tail length and tail moment indicating DNA damage has been observed at the highest dose of CAP treatment when compared to controls. Treatment of cells with CAP plus EGCG prevented CAP-induced changes in antioxidant enzyme activities and MDA level and mean tail lenght indicating DNA damage. A significant increase in mean tail lenght was observed at high doses of CAP. These data suggest that EGCG can prevent toxicity to human erythrocytes and leucocytes caused by CAP, only at low doses.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protective effect of (−)-epigallocatechin-3-gallate on capsaicin-induced DNA damage and oxidative stress in human erythrocyes and leucocytes in vitro

Pandır

2014

Cytotechnology

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“…Judging by the findings reported by Banji et al (32), lycopene shows better (synergistic) effects if combined with Zn supplements. We can assume that higher lycopene levels would have induced higher Zn transport to liver in the presence of OTA.…”

Section: Liver Trace Element Levelsmentioning

confidence: 92%

Lycopene restores trace element levels in ochratoxin A-treated rats

Palabıyık

Erkekoğlu

Kızılgün³

et al. 2017

Archives of Industrial Hygiene and Toxicology

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This study was designed to investigate the in vivo effects of ochratoxin A (OTA) and/or lycopene on the levels of selenium, zinc, and copper in the liver, kidneys, and testes of male Sprague-Dawley rats. The rats were treated with OTA (0.5 mg kg-1 day-1) and/or lycopene (5 mg kg-1 day-1) by gavage for 7 or 14 days. Trace element levels were measured by atomic absorption spectrometry. OTA significantly lowered selenium (20 % in the liver, 17 % in the kidney, and 40 % in the testis), zinc (24 % in the liver, 23 % in the kidney, and 26 % in the testis), and copper levels (40 % in the liver and 10 % in the kidney). Lycopene alone did not affect the trace element levels in any of the organs. In combination with OTA, however, it significantly restored liver, kidney, and testis selenium and zinc levels compared to the group treated with OTA alone. Our results have confirmed that depletion of trace elements in different organs is one of the mechanisms of action of OTA. They also suggest that lycopene interferes with this depleting effect and restores trace element levels, the implications of which need to be further investigated.

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“…Capsaicin ( trans ‐8‐methyl‐ N ‐vanillyl‐6‐nonenamide; CAP) is a naturally occurring alkaloid derived from the plants of genus Capsicum family, and it is a nonphenolic compound, which contains amide and lipophilic carbon chain on the one end and a hydrophilic ring on the other. Capsaicin is the major pungent ingredient in chili peppers and is increasingly being used in the food and pharmaceutical industries. Capsaicin exerts various pharmacologic and physiologic effects on a body, such as analgesia, anticancer, antiinflammation, antioxidant, and antiobesity.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of capsaicin inhibition of aldose reductase activity

Alım

Kılınç

Şengül

et al. 2017

J Biochem & Molecular Tox

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Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive and a drug in a number of diverse clinical trials. The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain). We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues. K values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR. In conclusion, capsaicin may be an effective molecule when used in low concentrations to prevent diabetic complications associated with the polyol pathway.

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Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice

Cited by 15 publications

References 46 publications

Protective effect of (−)-epigallocatechin-3-gallate on capsaicin-induced DNA damage and oxidative stress in human erythrocyes and leucocytes in vitro

Protective effect of (−)-epigallocatechin-3-gallate on capsaicin-induced DNA damage and oxidative stress in human erythrocyes and leucocytes in vitro

Lycopene restores trace element levels in ochratoxin A-treated rats

Mechanism of capsaicin inhibition of aldose reductase activity

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