The Effect of Sulfamethoxazole and Selenium on Antioxidant Defense System in the Blood of Rats Treated With DEN

Gupta, Ritu

doi:10.9790/3008-0862937

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…Observed decrease in hemoglobin content can be related with decrease in RBC level which may precipitate anemic condition. 19 Enzymatic antioxidants such as catalase, GSHP X , and SOD protect organs from drug-induced oxidative stress and decreases in their levels connote organ injury. 20 In this study, observed decrease in enzymatic antioxidants levels in animals treated with LPV/r is consistent with some reported observations.…”

Section: Discussionmentioning

confidence: 99%

Effect of co-administered lopinavir/ritonavir and sulfamethoxazole/trimethoprim on cardiac function and architecture of albino rats

Adikwu

Oputiri²,

Jimmy³

et al. 2014

Int J Basic Clin Pharmacol

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Section: Discussionmentioning

confidence: 99%

Effect of co-administered lopinavir/ritonavir and sulfamethoxazole/trimethoprim on cardiac function and architecture of albino rats

Adikwu

Oputiri²,

Jimmy³

et al. 2014

Int J Basic Clin Pharmacol

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Whey protein concentrate and lactoferrin alleviated anaemia, immunotoxicity, and biochemical alterations in a mouse model of early hepatocarcinogenesis

Ramadan

Mohammed

Zoheiry

et al. 2020

International Dairy Journal

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Therapeutic potential of a novel combination of Curcumin with Sulfamethoxazole against carbon tetrachloride-induced acute liver injury in Swiss albino mice

Zahran

Geba

Tabll

et al. 2020

Journal of Genetic Engineering and Biotechnology

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Background In the current study, we have investigated the effect of each of curcumin (CUR) and sulfamethoxazole (SMX) either separate or mixed together (CUR + SMX) on biochemical, hematological and histological alternations associated with carbon tetrachloride (CCl4)-induced liver fibrosis in mice. Results CCl4, caused changes of several biomarkers, proving its hepatotoxic effects, such as an increase in aminotransferases liver enzymes alanine and aspartate transaminases (ALT, AST), malondialdehyde (MDA), and nitric oxide (NO) formation, with a decrease in superoxide dismutase (SOD), glutathione reductase (GSSG), total antioxidant capacity (TAO), glutathione (GSH), total protein, and albumin, compared to a negative control mice group. Compared to the CCl4 group of mice, the CUR and SMX separate and/or together (CUR + SMX) treatments showed significance in (p < 0.001), ameliorated liver injury (characterized by an elevation of (ALT, AST) and a decrease (p < 0.001) in serum albumin and total protein), antioxidant (characterized by a decrease in (p < 0.001) MDA, NO; an increase (p < 0.001) SOD, GSSG, TAO; and reducing GSH), hematological changes (characterized by a decrease (p < 0.001) in white blood cells count and an increase (p < 0.001) in platelets count, hematocrit levels, hemoglobin concentration, and (p < 0.05) red blood cells count), SDS-PAGE electrophoresis with a decrease in protein synthesis and changes in histological examinations. Conclusions CUR and SMX either separate or together (SUR + SMX) may be considered promising candidates in the prevention and treatment of liver fibrosis.

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The Effect of Sulfamethoxazole and Selenium on Antioxidant Defense System in the Blood of Rats Treated With DEN

Abstract: Objective: This study aims to elucidate the combined effect of sulfamethoxazole (SMX)

Cited by 5 publications

References 42 publications

Effect of co-administered lopinavir/ritonavir and sulfamethoxazole/trimethoprim on cardiac function and architecture of albino rats

Effect of co-administered lopinavir/ritonavir and sulfamethoxazole/trimethoprim on cardiac function and architecture of albino rats

Whey protein concentrate and lactoferrin alleviated anaemia, immunotoxicity, and biochemical alterations in a mouse model of early hepatocarcinogenesis

Therapeutic potential of a novel combination of Curcumin with Sulfamethoxazole against carbon tetrachloride-induced acute liver injury in Swiss albino mice

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