Therapeutic potential of a novel combination of Curcumin with Sulfamethoxazole against carbon tetrachloride-induced acute liver injury in Swiss albino mice

Abstract

Background In the current study, we have investigated the effect of each of curcumin (CUR) and sulfamethoxazole (SMX) either separate or mixed together (CUR + SMX) on biochemical, hematological and histological alternations associated with carbon tetrachloride (CCl4)-induced liver fibrosis in mice. Results CCl4, caused changes of several biomarkers, proving its hepatotoxic effects, such as an increase in aminotransferases liver enzymes alanine and aspartate transaminases (ALT, AST), malondialdehyde (MDA), and nitric oxide (NO) formation, with a decrease in superoxide dismutase (SOD), glutathione reductase (GSSG), total antioxidant capacity (TAO), glutathione (GSH), total protein, and albumin, compared to a negative control mice group. Compared to the CCl4 group of mice, the CUR and SMX separate and/or together (CUR + SMX) treatments showed significance in (p < 0.001), ameliorated liver injury (characterized by an elevation of (ALT, AST) and a decrease (p < 0.001) in serum albumin and total protein), antioxidant (characterized by a decrease in (p < 0.001) MDA, NO; an increase (p < 0.001) SOD, GSSG, TAO; and reducing GSH), hematological changes (characterized by a decrease (p < 0.001) in white blood cells count and an increase (p < 0.001) in platelets count, hematocrit levels, hemoglobin concentration, and (p < 0.05) red blood cells count), SDS-PAGE electrophoresis with a decrease in protein synthesis and changes in histological examinations. Conclusions CUR and SMX either separate or together (SUR + SMX) may be considered promising candidates in the prevention and treatment of liver fibrosis.

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

“…In a study, eugenol caused a decrease in the SGOT, SGPT, and ALP serum marker enzyme levels triggered by metanil yellow (My1) in albino Wistar rats (40). It was stated that combination of Curcumin with Sulfamethoxazole decreased the elevated levels of hepatic markers (AST and ALT) against carbon tetrachloride induced liver injury in Swiss albino mice (41). Also, the intoxication of rats with CCl 4 caused a substantial rise in TG, Chol, TB, and DB serum levels relative to the control group.…”

The Dual Therapeutic Potential of Ottelione A on Carbon Tetrachloride-induced Hepatic Toxicity in Mice

“…CCl 4 toxicity causes free radical reactions through enzymes of the CYP 450 system, producing hepatotoxic metabolites. These metabolites cause hepatotoxicity through induction of lipid peroxidation, that all together gives MDA and NO products that serve as an indicator of hepatic toxicity and failure of protective mechanisms to delay the free radical formation [ 43 ]. OTTE reduces the MDA and NO in the liver significantly as compared to the CCl 4 -treated group at post-treatment, thus the OTTE has a therapeutic efficacy.…”

Effect of Sericin and Curcumin Mixture on Hematological Alternations Associated with Carrageenan Induced Paw Edema in Mice

“…Our results (Figure 3) showed that in response to carrageenan injection, the platelet number dropped down, whereas sericin and curcumin ameliorated the platelet count in a dose dependent manner. Previously, many researchers reported that sericin and curcumin can elevate the count of platelets in inflammatory conditions (Ma et al, 2021;Zahran et al, 2020). Zahran et al (2020) evaluated the therapeutic potential of curcumin alone and together with sulfamethoxazole in mice.…”

“…Previously, many researchers reported that sericin and curcumin can elevate the count of platelets in inflammatory conditions (Ma et al, 2021;Zahran et al, 2020). Zahran et al (2020) evaluated the therapeutic potential of curcumin alone and together with sulfamethoxazole in mice. They demonstrated that curcumin alone or in combination with sulfamethoxazole has potential to enhance platelet count.…”