Supplemental Calcium and Risk Reduction of Hypertension, Pregnancy-Induced Hypertension, and Preeclampsia: An Evidence-Based Review by the US Food and Drug Administration

Trumbo, Paula R.; Ellwood, Kathleen C.

doi:10.1111/j.1753-4887.2007.tb00284.x

Cited by 59 publications

(44 citation statements)

References 63 publications

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“…13 Our findings are similar to many former studies by Onyegbule et al, 5 Sultana et al, 9 Sirajwala et al, 11 Akhtar et al, 13 and Moholkar et al 15 In contrast, some researchers did not demonstrate significant difference between the two groups. 16,17 These contrasting findings may be due to differences in genetic pool of population, method of sample collection, storage and processing of sample, and method of analysis. 7 So, from our study, we can deduce that hypocalcemia is significantly associated with preeclampsia and serum calcium may have a role in its etiology.…”

Section: Discussionmentioning

confidence: 96%

Comparative Study of Serum Calcium in Preeclampsia and Normal Pregnancy at Government Medical College and Hospital, Aurangabad City, India

2017

Indian Journal of Medical Biochemistry

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Introduction Preeclampsia, a pregnancy-specific disorder, is a global health problem. The major mineral calcium has been proposed to play an important role in the pathogenesis of pre-eclampsia. The present study was aimed to compare the level of serum calcium in normal pregnant women and in preeclampsia and determine the association of serum calcium with severity of the disease. Study design This study included 60 pregnant women diagnosed with preeclampsia as cases and 60 healthy pregnant women as controls in the third trimester of gestation. The concentration of total serum calcium was measured in both groups. Results Serum calcium level was significantly decreased in preeclamptic women than in normal pregnant women. Serum calcium showed significant negative correlation with systolic and diastolic blood pressure. Conclusion Hypocalcemia found in preeclamptic women in our study suggests that serum calcium may have a role in the etiopathogenesis of this disorder. Routine estimation of serum calcium may be useful as a diagnostic marker in preeclampsia. How to cite this article Aghade SM, Bavikar JS. Comparative Study of Serum Calcium in Preeclampsia and Normal Pregnancy at Government Medical College and Hospital, Aurangabad City, India. Indian J Med Biochem 2017;21(2):147-150.

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Section: Discussionmentioning

confidence: 96%

Comparative Study of Serum Calcium in Preeclampsia and Normal Pregnancy at Government Medical College and Hospital, Aurangabad City, India

2017

Indian Journal of Medical Biochemistry

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“…Furthermore, vitamin D deficiency during pregnancy was associated with increased primary caesarean section rate (13) . However, some reports have shown that Ca and vitamin D supplementation did not affect pregnancy outcomes in mothers without GDM (14,15) . Vitamin D and Ca might affect pregnancy outcomes through influencing skeletal composition and smooth muscle strength (13) as well as metabolic profiles (16) .…”

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confidence: 99%

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

Karamali

Asemi

Ahmadi-Dastjerdi

et al. 2015

Public Health Nutr.

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Objective: The present study was designed to assess the effects of Ca + vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM). Design: A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca + vitamin D supplements or placebo. Individuals in the Ca + vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 µg (50 000 IU) of cholecalciferol (vitamin D 3 ) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined. Setting: A urban community setting in Arak, Iran. Subjects: Sixty women with GDM and their newborns, living in Arak, Iran were enrolled. Results: Women treated with Ca + vitamin D had a significant decrease in caesarean section rate (23·3 % v. 63·3 %, P = 0·002) and maternal hospitalization (0 v. 13·3 %, P = 0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca + vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 % (P = 0·03). Lower rates of hyperbilirubinaemia (20·0 % v. 56·7 %, P = 0·03) and hospitalization (20·0 % v. 56·7 %, P = 0·03) were also seen in the supplemented group of newborns than in the placebo group. Conclusions: Ca + vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns.

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“…However, Trumbo et al 65,66 reported that calcium supplementation in women with low-calcium diets resulted in no change in PE rates although there was a decrease in the rate of severe PE complications. Moreover, a negative correlation between calcium intake and incidence of PE has recently been detected in Guatemala, Colombia and India 67 .…”

Section: Vitamin Dmentioning

confidence: 99%

Folate Metabolism and Preeclampsia

Guo

Smith

Wen

et al. 2012

Fet. Matern. Med. Rev.

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INTRODUCTIONPreeclampsia (PE) is a multisystem disorder of human pregnancy, affecting about 6% of all pregnancies worldwide, and is one of the leading causes of maternal and infant morbidity and mortality. Despite decades of research into the pathogenesis of this complex disease, the underlying mechanisms remain unclear. As a result, the options for prevention and management of PE are limited. In recent years, there has been a growing body of evidence suggesting that folate deficiency is associated with PE, and folic acid supplementation may reduce the risk of developing PE in certain populations. Folate contributes to cell division and growth, and folate metabolism is involved in a large number of physiological and pathophysiological processes in human development. Sufficient supply of folate is therefore particularly important during pregnancy. Nevertheless, the exact mechanisms of folic acid deficiency increasing the risk of developing PE are still unclear. This article reviews what is understood about the aetiology of PE and the relationship between folate metabolism and PE so as to enhance further discussions on the subject. PREECLAMPSIAPreeclampsia, a syndrome characterized clinically by hypertension and proteinuria, is a leading cause of maternal and perinatal morbidity and mortality worldwide. It affects approximately 6% of all pregnancies resulting in about 8.37 million cases worldwide 1-3 .

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Supplemental Calcium and Risk Reduction of Hypertension, Pregnancy-Induced Hypertension, and Preeclampsia: An Evidence-Based Review by the US Food and Drug Administration

Cited by 59 publications

References 63 publications

Comparative Study of Serum Calcium in Preeclampsia and Normal Pregnancy at Government Medical College and Hospital, Aurangabad City, India

Comparative Study of Serum Calcium in Preeclampsia and Normal Pregnancy at Government Medical College and Hospital, Aurangabad City, India

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

Folate Metabolism and Preeclampsia

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