Comparative Study of Serum Calcium in Preeclampsia and Normal Pregnancy at Government Medical College and Hospital, Aurangabad City, India

doi:10.5005/jp-journals-10054-0039

Cited by 4 publications

(8 citation statements)

References 9 publications

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“…In another study Paul et al [32] found the mean systolic blood pressure was 145.75±18.44 (mmHg) in preeclamptic patients. Similar observations also observed by Osman et al [35] , Bakacak et al [34] and Dabbaghmanesh et al [46] . In this current study, it was observed that the mean diastolic blood pressure was 97.83±4.85 mmHg.…”

Section: Discussionsupporting

confidence: 87%

“…Abnormal placentation in preeclampsia leads to decreased activation, increased catabolism, and impaired placental uptake of vitamin D and is unable to produce sufficient levels of 1,25-(OH)2 vitamin D [33] . In this present study, it was observed that [34] obtained in their study that ~ 94 ~ vitamin D levels were lower in preeclamptic patients compared to healthy normotensive pregnant women (p<0.001). Vitamin D supplementation is considered to decrease the risk of preeclampsia in the patient population at risk for vitamin D deficiency.…”

Section: Discussionsupporting

confidence: 47%

“…Similarly, Aghade and Bavikar et al [33] showed the mean age was 24.40±3.8 years in mild preeclampsia, 25.0±4.3 years in severe preeclampsia and 25.50±2.9 years in controls. In another study Bakacak et al [34] found the mean age was 29.2±8.40 in preeclampsia and 28.9±5.80 in healthy pregnant. The difference was statistically not significant (p>0.05), which are comparable with the current study.…”

Section: Discussionmentioning

confidence: 89%

“…The difference was statistically not significant (p>0.05) between two groups. Bakacak et al [34] study found the mean height was 161.06.47 cm in preeclampsia and 160.4±5.04 cm in healthy pregnant. The difference was statistically not significant (p>0.05) between two groups, which is a little higher with the present study.…”

Section: Discussionmentioning

confidence: 91%

“…The mean BMI was significantly (p<0.05) higher in patients with preeclampsia. On the other hand Bakacak et al [34] found the mean BMI was 29.3±4.75 kg/m² in Preeclampsia and 30.6±3.72 kg/m² in healthy pregnant. The difference was statistically not significant (p>0.05) between two groups.…”

Section: Discussionmentioning

confidence: 94%

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Association of Maternal Serum Vitamin D with Preeclampsia

Anan,

Nasrin,

Ferdous

et al. 2023

Int. J. Clin. Obstet. Gynaecol.

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Preeclampsia is a pregnancy specific disorder in which hypertension and proteinuria occurs after 20 weeks of gestation. Preeclampsia and other hypertensive disorders of pregnancy are a leading cause of maternal and infant illness and dead. But the exact pathophysiology is yet to be explored. Maternal vitamin D deficiency during pregnancy may be an independent risk factor for preeclampsia. The objective of this study is to explore the association of maternal serum vitamin D with preeclampsia. The aim of the study is to evaluate the association of maternal serum vitamin D level with preeclampsia. A cross sectional comparative study carried out in the Department of Obstetrics and Gynecology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka for a period of twelve months. A total of 60 women between 28 to 37 complicated weeks of gestation were included in this study. Among them, 30 pregnant woman with preeclampsia were included as group-I and rest 30 pregnant woman without preeclampsia were served as group-II. After all aseptic precaution, 6 ml of fasting blood sample were collected from all the study subjects for estimation of serum vitamin D. Containers of urine samples were collected for estimation of urinary protein. All data were recorded, processed and plotted in tabular and figure form. Statistical analyses of the results were obtained by using window based computer software devised with Statistical Packages for Social Sciences (SPSS-22). The mean age was 27.00±3.54 years in group I and 26.23±3.5 years in group II. The mean BMI was 26.09±6.05 kg/m² in group I and 24.12±2.81 kg/m² in group II. The difference of BMI was statistically significant (p<0.05) between two groups. More than half (53.3%) patients belonged to vitamin D level <10 ng/ml in group I and 5(16.7%) in group II. The mean vitamin D level was 9.77±1.98 ng/ml in group I and 12.78±3.01 ng/ml in group II. The difference was statistically significant (p<0.05) between two groups. A negative significant p=0.002) between serum vitamin D level with systolic blood pressure. Another negative significant p=0.004) between serum vitamin D level with diastolic blood pressure. The study concluded low maternal serum Vitamin D level increases the risk of preeclampsia.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 94%

See 3 more Smart Citations

Association of Maternal Serum Vitamin D with Preeclampsia

Anan,

Nasrin,

Ferdous

et al. 2023

Int. J. Clin. Obstet. Gynaecol.

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Serum 25 (Oh) Vitamin D and Calcium Levels and Adverse Maternal and Perinatal Outcomes in Pregnancy Induced Hypertension

MONIKA,

KHILLAN,

GARG

et al. 2024

Asian J Pharm Clin Res

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Objectives: Incidence of hypertensive disorders in pregnancy is about 5–10% of all pregnancies [1]. Pre-eclampsia alone or superimposed on chronic hypertension is the most threatening. This study is done to evaluate the levels of serum 25 (OH) Vitamin D and Calcium in normal antenatal patients and patients with pregnancy-induced hypertension and their effects on perinatal and maternal outcome. Hence, that timely intervention can prevent adverse perinatal and maternal outcomes. Methods: The present prospective observational study was done in the Department of Obstetrics and Gynecology, Government Medical College and Rajindra Hospital, Patiala, Punjab, India from May 2018 to April 2019. The study was conducted on 80 antenatal patients. Patients were divided into two groups with 40 patients in each group. Group I included patients with pregnancy-induced hypertension and Group II included normal antenatal patients. Serum levels of calcium and 25 (OH) Vitamin D were evaluated in both groups. Adverse perinatal and maternal outcomes were assessed in relation to the serum levels of calcium and 25 (OH) Vitamin D in patients with pregnancy-induced hypertension and normal antenatal patients. Categorical variables were analyzed by Chi-square test and Fisher’s exact test. The analysis of continuous variable was done by ANOVA. The data were analyzed using SPSS version 22 and Microsoft Excel. p≤0.05 is taken as statistically significant. Results: The mean value of serum Vitamin D level in Group I was 22.30±6.11 ng/ml and 36.68±9.34 ng/ml in Group II giving p=0.016 which was highly significant. In Group I, mean calcium levels were 8.58±0.63 mg/dl and 9.27±0.40 mg/dl in Group II giving p=0.018 which was highly significant. The Pearson’s correlation coefficient was −0.753 for serum Vitamin D and systolic blood pressure (BP) and the same for serum Vitamin D and diastolic BP with p=0.001 which was highly significant. The Pearson correlation coefficient was −0.537, −0.514 for serum calcium and systolic BP and serum calcium and diastolic BP, respectively, giving p=0.001. Conclusion: Serum levels of 25 (OH) Vitamin D and calcium have a significant relationship with pregnancy-induced hypertension. Low levels of calcium and 25 (OH) Vitamin D cause an increased risk of pregnancy-induced hypertension and supplementation of these reduces the incidence of pregnancy-induced hypertension. Hence, their supplementation can be used as a possible intervention strategy in preventing one of the most common causes of perinatal and maternal morbidity and mortality around the world.

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Comparative Study of Serum Calcium and Magnesium Levels in Women With Pre Eclampsia and Normotensive Pregnant Women

Das

Agarwal

2022

IJAR

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Objectives: The objective of the study is to establish a relation between serum calcium and magnesium levels with severity of pre-eclampsia and to compare the levels with normotensive pregnant women. Materials And Methods: 200 women with pre-eclampsia and 200 normotensive pregnant women were included in this hospital based, cross sectional study; serum calcium and magnesium levels were measured and data was analysed. The serum calcium concentration wasResults: signicantly lower in pre-eclamptic cases as compared to normotensive controls. (7.903±0.292 Vs 9.227±0.598 mg/dl, p < 0.001). Serum magnesium concentration was signicantly lower in severe preeclampsia cases as compared to mild preeclampsia. (7.67±0.32 Vs 7.991±0.22 mg/dl, p<0.001). Measurements of serum calcium and magnesium among women at risk may be used toConclusion: predict onset and severity of pre-eclampsia.

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Comparative Study of Serum Calcium in Preeclampsia and Normal Pregnancy at Government Medical College and Hospital, Aurangabad City, India

Cited by 4 publications

References 9 publications

Association of Maternal Serum Vitamin D with Preeclampsia

Association of Maternal Serum Vitamin D with Preeclampsia

Serum 25 (Oh) Vitamin D and Calcium Levels and Adverse Maternal and Perinatal Outcomes in Pregnancy Induced Hypertension

Comparative Study of Serum Calcium and Magnesium Levels in Women With Pre Eclampsia and Normotensive Pregnant Women

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