Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

Karamali, Maryam; Asemi, Zatollah; Ahmadi-Dastjerdi, Maedeh; Esmaillzadeh, Ahmad

doi:10.1017/s1368980015000609

Cited by 46 publications

(40 citation statements)

References 50 publications

(58 reference statements)

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“…Previous study showed that the cumulative incidence of type 2 diabetes mellitus was 6 weeks to 28 years in postpartum women with GDM ( 5 ). GDM has negative effects on future generations, including neonatal death ( 6 ), stillbirth ( 7 ), perinatal mortality ( 8 ), preeclampsia ( 9 ), large fetus ( 10 ), neonatal jaundice ( 11 ), low blood sugar ( 12 ), low calcium ( 13 ), and so on. However, the pathogenesis of GDM is still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Polysaccharide IV from Lycium barbarum L. Improves Lipid Profiles of Gestational Diabetes Mellitus of Pregnancy by Upregulating ABCA1 and Downregulating Sterol Regulatory Element-Binding Transcription 1 via miR-33

Yang

Fan

et al. 2018

Front. Endocrinol.

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Lycium barbarum L. (LBL) has beneficial effects on gestational diabetes mellitus (GDM) but the related mechanism remains unclear. Polysaccharides of LBL (LBLP) are the main bioactive components of LBL. miR-33, ATP-binding cassette transporter A1 (ABCA1) and sterol regulatory element-binding transcription 1 (SREBF1) affect lipid profiles, which are associated with GDM risk. LBLP may exert protective against GDM by affecting these molecules. Four LBLP fractions: LBLP-I, LBLP-II, LBLP-III, and LBLP-IV were isolated from LBL and further purified by using DEAE-Sephadex column. The effects of purified each fraction on pancreatic beta cells were comparatively evaluated. A total of 158 GDM patients were recruited and randomly divided into LBL group (LG) and placebo group (CG). miR-33 levels, lipid profiles, insulin resistance and secretory functions were measured. The association between serum miR-33 levels and lipid profiles were evaluated by using Spearman’s rank-order correlation test. After 4-week therapy, LBL reduced miR-33 level, insulin resistance and increased insulin secretion of GDM patients. LBL increased the levels of ABCA1, high-density lipoprotein cholesterol (HDL-C) and reduced miR-33, SREBF1, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), and malondialdehyde. Homeostatic model assessment of β-cell function and insulin resistance was lower in LG than in CG, whereas homeostatic model assessment of β-cell function and insulin secretory function was higher in LG than in CG. There was a strong positive association between miR-33 level and TG, or TC and or LDL-C, and a strong negative association between miR-33 level and HDL-C. The levels of miR-33 had negative relation with ABCA1 and positive relation with SREBF1. ABCA1 has negative relation with TG, TC, and LDL-C and positive relation with HDL-C. Inversely, SREBF1 had positive relation with TG, TC, and LDL-C and negative relation with HDL-C. The main bioactive compound LBLP-IV of LBL increased insulin secretion of beta cells and the levels of ABCA1, and reduced miR-33 levels and SREBF1 in beta cells. However, LBLP-IV could not change the levels of these molecules anymore when miR-33 was overexpressed or silenced. LBLP-IV had the similar effects with LBL on beta cells while other components had no such effects. Thus, LBLP-IV from LBL improves lipid profiles by upregulating ABCA1 and downregulating SREBF1 via miR-33.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Polysaccharide IV from Lycium barbarum L. Improves Lipid Profiles of Gestational Diabetes Mellitus of Pregnancy by Upregulating ABCA1 and Downregulating Sterol Regulatory Element-Binding Transcription 1 via miR-33

Yang

Fan

et al. 2018

Front. Endocrinol.

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“…The present investigation found that the occurrence of preeclampsia, gestational diabetes, preterm birth, SGA, and caesarean section were not different between groups. The effect of vitamin D supplementation on the pregnancy outcomes including preeclampsia, gestational diabetes, and spontaneous abortion has not been confirmed by several RCTs (Asemi, Karamali, & Esmaillzadeh, ; Karamali, Asemi, Ahmadi‐Dastjerdi, & Esmaillzadeh, ; Perez‐Lopez et al, ; Roth et al, ). Nonetheless, there are few interventional studies with large sample size that support the positive effect of vitamin D supplementation during pregnancy on pregnancy outcomes (De‐Regil et al, ).…”

Section: Discussionmentioning

confidence: 98%

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Motamed

Nikooyeh

Kashanian

et al. 2019

Maternal & Child Nutrition

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Hypovitaminosis D during pregnancy is suggested to have a link with complications in both mother and infant. We aimed to evaluate the efficacy of two doses of vitamin D3 supplementation during pregnancy on maternal and cord blood vitamin D status, inflammatory biomarkers, and maternal and neonatal outcomes. A total of 84 pregnant women (gestational age of <12 weeks) were randomly allocated to one of two groups: (a) 1,000‐IU/d vitamin D and (b) 2,000 IU/d. Biochemical assessments (25‐hydroxycalciferol (25(OH)D), hs‐CRP, and cell‐culture supernatant concentrations of IL‐1β, IL‐6, and TNF‐α) of mothers were performed at the beginning and 34 weeks of gestation. Assessments of infants at delivery comprised cord blood serum concentrations of 25(OH)D, hs‐CRP, IL‐1β, IL‐6, TNF‐α, birth sizes, and Apgar score. Circulating concentrations of 25(OH)D increased in both intervention groups with more increment in 2,000 IU/d than in 1,000 IU/d (46.7 ± 30.7 vs. 24.0 ± 21.07 nmol L−1, P = .001). Concentrations of TNF‐α decreased significantly in group 2,000 (−913.1 ± 1261.3 ng L−1, P = .01). The cord blood concentration of IL‐6 in group 2,000 IU/d, compared with 1,000 IU/d, was significantly lower (25.9 ± 32.0 vs. 4.6 ± 1.4 ng L−1, P = .03). The birth sizes including weight, length, and head circumference of the infants of group 2,000 IU/d were significantly higher than the infants' of group 1,000 IU/d. Supplementation with 2,000‐IU/d vitamin D3 is more effective than 1,000 IU/d in pregnant women in terms of increasing circulating 25(OH)D, ameliorating pro‐inflammatory markers notably TNF‐α in mother and IL‐6 in cord blood, and improving neonatal outcomes including the birth sizes.

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“…Similarly, a separate trial of 84 women supplemented with calcium and vitamin D, vitamin D only, or placebo, again found no differences in CS rates between groups, and this may be due to 30% of the sample having had a previous CS. 70 However, results from a recent trial by Karamali et al 71 involving 60 women with existing GDM found that those supplemented with 50,000 IU vitamin D and 1,000 mg calcium at baseline and at 21 days had decreased rates of CS compared with placebo (63.3% vs 23.3%), but these effects cannot be attributed to vitamin D since it was combined with calcium.…”

Section: Caesarean Sectionmentioning

confidence: 99%

“…In addition, both the observational and intervention studies discussed are limited by the fact that indicators for CS are highly variable, often protocol-driven, and rely heavily on hospital facilities and obstetric experience, as well personal preference of the mother. 71 Thus, the preventive potential of vitamin D on CS cannot be derived from existing studies, and the contextual variations driving CS rates should be considered in the design and execution of future trials.…”

Section: Caesarean Sectionmentioning

confidence: 99%

Vitamin D in Reproductive Health and Pregnancy

2016

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Vitamin D has been primarily known for its role in maintaining calcium and phosphorus homeostasis and promoting healthy bone mineralization. Emerging evidence suggests that vitamin D may have a plethora of other functions including cardiometabolic and immunological effects and a role in modulating human reproductive processes. Despite this, vitamin D deficiency (VDD) remains highly prevalent worldwide due to the limited availability of foods that are naturally high or fortified with vitamin D, increased sun avoidance behaviors and use of sunscreen due to fear of skin cancer, and increased sedentary indoor lifestyles, especially among those of reproductive age. This review examines current and emerging evidence for the role of vitamin D in reproductive health including in fertility, conception, and pregnancy outcomes, and outlines areas for future research. We found that existing evidence is based primarily on animal models and in vitro studies with some recent support from observational studies in humans. While these studies indicate that VDD may be a risk factor for adverse fertility and pregnancy outcomes, there is insufficient evidence to establish causality. Future efforts to clarify the benefits of vitamin D in reproductive health may bring about practical, simple, and cost-effective means of improving fertility and pregnancy outcomes.

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Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

Cited by 46 publications

References 50 publications

RETRACTED: Polysaccharide IV from Lycium barbarum L. Improves Lipid Profiles of Gestational Diabetes Mellitus of Pregnancy by Upregulating ABCA1 and Downregulating Sterol Regulatory Element-Binding Transcription 1 via miR-33

RETRACTED: Polysaccharide IV from Lycium barbarum L. Improves Lipid Profiles of Gestational Diabetes Mellitus of Pregnancy by Upregulating ABCA1 and Downregulating Sterol Regulatory Element-Binding Transcription 1 via miR-33

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Vitamin D in Reproductive Health and Pregnancy

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