Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Motamed, Soudabe; Nikooyeh, Bahareh; Kashanian, Maryam; Hollis, Bruce W.

doi:10.1111/mcn.12867

Cited by 21 publications

(19 citation statements)

References 60 publications

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“…In a randomized clinical trial from Iran, vitamin D supplementation with 1000 IU/day was compared to that with 2000 IU/day. In both groups, 25-OH-D concentrations increased, but a significantly higher increase was observed in the 2000 IU/day group [27].…”

Section: Discussionmentioning

confidence: 82%

Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?

et al. 2020

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Controversy remains surrounding vitamin D routine supplementation in healthy pregnancy, and the doses are unclear. The aim of this study was to describe maternal vitamin D status throughout pregnancy in a group of Mexican women and evaluate the effect of frequently prescribed doses of vitamin D3 on longitudinal 25-OH-D concentrations, adjusting for obesity, season, and other factors. We conducted a cohort study (Instituto Nacional de Perinatología-INPer) (2017–2020)) of healthy pregnant women without complications. Pregestational overweight/obesity (body mass index ≥ 25), vitamin D3 supplementation (prescribed by physician; 0–250, 250–400, and >400 IU/day), and serum 25-OH-D concentrations (ELISA) were evaluated in each trimester of pregnancy. Vitamin D deficiency or insufficiency was computed (<20 and <30 ng/mL, respectively). We studied 141 adult women; 58.5% had pregestational obesity or overweight. In the first trimester, 45.8% of the women were supplemented with vitamin D3; 51.4% had vitamin D insufficiency and 37.3%, deficiency. In the third trimester, 75.4% of the women were supplemented, and 20% of them still had deficiency. The final general mixed linear model showed that 25-OH-D significantly increased throughout pregnancy (p < 0.001); the highest increase was observed in the third trimester in women with doses >400 IU/day of vitamin D3 (+4 ng/mL, 95% CI: 1.72–8.11 ng/mL). In winter/autumn, 25-OH-D concentrations were also lower (p ≤ 0.05). In this group of pregnant Mexican women, the prevalence of vitamin D deficiency and insufficiency was high. A higher increase in 25-OH-D concentrations during pregnancy was observed when the women were supplemented with >400 IU/day. Common supplementation doses of 250–400 IU/day were insufficient for achieving an adequate maternal vitamin D status.

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Section: Discussionmentioning

confidence: 82%

Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?

et al. 2020

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“…Of the 44 trials selected, vitamin D supplementation during pregnancy showed a statistically significant association with at least one of the outcomes assessed in 35 studies. 12,[16][17][18][19][20][21][22][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][44][45][46][47][48][50][51][52][53] In relation to anthropometric outcomes, the effects were: greater length, 16,18 weight 16 and head circumference at birth 16 , and greater linear growth in the first year of life. 12 The doses of 1,000 to 4,000 IU/day, 14,000 to 35,000 IU/ week, and 50,000 IU/month of vitamin D3 were identified as the minimum necessary to ensure adequate concentrations of vitamin D in early childhood.…”

Section: Resultsmentioning

confidence: 99%

Effects of Vitamin D Supplementation During Pregnancy on Newborns and Infants: An Integrative Review

Dutra

Souza

Konstantyner

2021

Rev. paul. pediatr.

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Objective: To identify the effects of vitamin D supplementation during pregnancy on newborns and infants. Data sources: The present study is an integrative review of literature based on clinical trials published in journals indexed in the PubMed and Web of Science databases. Two searches were carried out, starting with the association (and) of the health term “vitamin D” with “pregnancy”. In the search for information, selection criteria were established, and there was no language limitation and year of publication. Data synthesis: The final selection resulted in 44 clinical trials, most of which were randomized and double blind, which were carried out in outpatient clinics, referral hospitals and universities, mainly in Europe. The samples studied were predominantly of newborns. In these 44 trials, 23 types of different doses of vitamin D during pregnancy, with different doses, regimens and times of use, and 14 different outcomes were studied in newborns (NB) and infants. Of the 44 studies performed, 35 showed statistically significant beneficial effects of vitamin D supplementation during pregnancy on newborns and infants compared to control groups. Conclusions: Vitamin D supplementation during pregnancy for at least three months before delivery has the potential of positively influencing calcium metabolism, physical growth and immune system development in newborns and infants. However, there is insufficient knowledge to define the optimal dose and to guarantee the absence of possible long-term adverse effects.

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“…To evaluate OS, serum concentrations of malondialdehyde (MDA) as well as total antioxidant capacity were determined. MDA assay was performed using thiobarbituric acid reacting substances (TBARS), as previously described [ 29 ]. To determine total antioxidant capacity (TAC), the ability of serum antioxidants to inhibit 2,2ˊ-azino di-(3-ethylbenzthiazoline sulfonate; ABTS) oxidation was compared with that of bovine serum albumin, as the standard [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

“…It is noteworthy that the Iran Ministry of Health (IrMOH) communicated with all governmental health centers to prescribe 1000 IU/d vitamin D supplement to all pregnant women from the beginning of pregnancy. However, the efficacy of supplementation with this dosage (1000 IU/d) early in pregnancy has not yet been evaluated and compared with that of 2000 IU/d, which has been more efficient in improving vitamin D status and depressing certain inflammatory biomarkers, than 1000 IU/d [29]. We, therefore, designed this clinical trial from the first trimester of pregnancy to examine and compare the efficacy of these two dosages of vitamin D (1000 IU/d and 2000 IU/d) on certain metabolic parameters including glycemic, lipidemic and parathyroid hormone as well as OS status.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

Motamed

Nikooyeh

Kashanian

et al. 2020

BMC Pregnancy Childbirth

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Background Vitamin D deficiency during pregnancy is common and is likely to be associated with metabolic complications in the mother. The aim of this study was to assess the efficacy of two doses of vitamin D supplementation during pregnancy on maternal and cord blood vitamin D status and metabolic and oxidative stress biomarkers. Methods The eligible pregnant women (n = 84) invited to participate in the study and randomly allocated to one of the two supplementation groups (1000 IU/d vitamin D and 2000 IU/d). Biochemical assessments of mothers including serum concentrations of 25(OH)D, calcium, phosphate, iPTH, fasting serum sugar (FBS), insulin, triglyceride, total cholesterol, LDL-C, HDL-C, malondialdehyde (MDA) and total antioxidant capacity (TAC) were done at the beginning and 34 weeks of gestation. Cord blood serum concentrations of 25(OH)D, iPTH, MDA and TAC were assessed at delivery as well. To determine the effects of vitamin D supplementation on metabolic markers 1-factor repeated-measures analysis of variance (ANOVA) was used. Between groups comparisons was done by using Independent-samples Student’s t-test or Mann-Whitney test. P < 0.05 was considered as significant. Results Supplementation with 1000 IU/d and 2000 IU/d vitamin D resulted in significant changes in vitamin D status over pregnancy (24.01 ± 21.7, P < 0.001 in 1000 IU/d group and 46.7 ± 30.6 nmol/L, P < 0.001 in 2000 IU/d group). Daily intake of 2000 compared with 1000 IU/d tended to increase the serum concentration of HDL-C (10 ± 8.37, P < 0.001 in 1000 IU/d group and 9.52 ± 11.39 mg/dL, P < 0.001 in 2000 IU/d group). A significant decrement in serum concentration of iPTH observed in both groups (− 4.18 ± 7.5, P = 0.002 in 1000 IU/d group and − 8.36 ± 14.17, P = 0.002 in 2000 IU/d group). Conclusions Supplementation with 2000 IU/d vitamin D as compared with 1000 IU/d, is more effective in promoting vitamin D status and HDL-C serum concentration and in decreasing iPTH over pregnancy. Trial registration This trial is registered at clinicaltrials.gov (NCT03308487). Registered 12 October 2017 ‘retrospectively registered’.

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Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Cited by 21 publications

References 60 publications

Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?

Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?

Effects of Vitamin D Supplementation During Pregnancy on Newborns and Infants: An Integrative Review

Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

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