Superparamagnetic Manganese Ferrite and Strontium Bioactive Glass Nanocomposites: Enhanced Biocompatibility and Antimicrobial Properties for Hyperthermia Application

Abstract

Herein, the strontium bioactive glass with ferrite composites is studied for the application of biocompatibility and magnetic hyperthermia. The bioactive glass SrBG (46.1SiO2–21.9CaO–24.4Na2O–2.6P2O5–5SrO) prepared by the melt quench technique at 1400 °C and manganese ferrite (MnFe2O4) prepared by the modified microwave reflux oven are mixed together and sintered at 400 °C for 6 h for making composites. The in vitro bioactivity of these composites is observed by immersing in simulated body fluid (SBF). The growth of the precipitated hydroxyapatite phase observed after SBF treatment is confirmed by the X‐ray diffractometer (XRD), Fourier transform infrared (FTIR) spectrometer, and scanning electron microscope (SEM) results. The in vitro cell viability assessment of these composites with MG‐63 cell lines indicates that the composites are biocompatible in nature. Furthermore, these composites show the antibacterial effect on the E. coli and S. Aureus bacteria cells. The room temperature superparamagnetic behavior accompanied by the heating ability in these composites proves their potential role for hyperthermia applications.

Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

“…It was speculated that the bacteriostatic action observed with the experimental orthodontic adhesives could be primarily due to the Sr-BGNPs since the potential benefits of Sr 2+ -release include both remineralizing and antibacterial actions 18 . This result was in accordance with those of previous studies that demonstrated the antibacterial actions of Sr-containing bioactive glasses 56 , 57 . It was speculated that the growth inhibition of S. mutans could be due to the release of Sr-BGNPs from the experimental adhesives due to the lack of silanization.…”

The effect of vanadium ferrite doping on the bioactivity of mesoporous bioactive glass-ceramics

“…A relative decrease in the pH of the SBF solution aer 9 days was also observed, which could either lead to silanol formation or to breaking of the glass network. 47,48 The morphological properties of the MBGCs also indicate the formation of an apatite-like layer on the surface of the samples following immersion in SBF.…”

A critical review of bioactive glasses and glass–ceramics in cancer therapy

“…194 Another approach to enhance BG properties relies on the design and production of composite materials. [195][196][197] Tripathi et al 198 combined strontium-containing BG (46.1SiO 2 -21.9CaO-24.4Na 2 O-2.6P 2 O 5 -5SrO wt%) with manganese ferrite (MnFe 2 O 4 ) to obtain a dual-phase magnetic composite with enhanced biocompatibility and antimicrobial properties. The results showed that this composite had an antibacterial effect on both Grampositive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria while exhibiting superparamagnetic characteristics and heating capability for potential use in hyperthermia application.…”

“…The results showed that this composite had an antibacterial effect on both Grampositive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria while exhibiting superparamagnetic characteristics and heating capability for potential use in hyperthermia application. 198 In another study, Bruno et al 199 have dispersed a ferrimagnetic BGC in a poly(methyl methacrylate) matrix, thus obtaining a composite cement. The glass-ceramic contained magnetite crystals embedded in an amorphous bioactive SiO 2 -Na 2 O-CaO-P 2 O 5 -FeO-Fe 2 O 3 matrix.…”