The effect of vanadium ferrite doping on the bioactivity of mesoporous bioactive glass-ceramics

Omidian, Sajjad; Nazarpak, Masoumeh Haghbin; Bagher, Zohreh; Moztarzadeh, Fathollah

doi:10.1039/d2ra04786a

Cited by 7 publications

(5 citation statements)

References 65 publications

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“…The 10-fold higher cytotoxicity in the current study toward HFF-1 cells, 1.9 ± 0.4 μM (Table ), presumably reflects the fact that cytotoxicities of HFF-1 cells are more sensitive to the details of the experiment, such as number of cells, the doubling rates, the number of passages, and other factors. The increase in cell viability at low V concentrations was not observed for the cancer T98g cell line (Figure S5b) but was reported previously for bone fibroblasts (osteoblasts) and can contribute to the known tissue-regenerating properties of V compounds. − Data within Figure S5b emphasize that the activities of anticancer drugs in various cell lines cannot be compared based on the IC 50 values alone.…”

Section: Resultssupporting

confidence: 52%

Vanadium Chloro-Substituted Schiff Base Catecholate Complexes are Reducible, Lipophilic, Water Stable, and Have Anticancer Activities

et al. 2022

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A hydrophobic Schiff base catecholate vanadium complex was recently discovered to have anticancer properties superior to cisplatin and suited for intratumoral administration. This [VO(HSHED)(DTB)] complex, where HSHED is N-(salicylideneaminato)-N′-(2-hydroxyethyl)-1,2-ethanediamine and the non-innocent catecholato ligand is di-t-butylcatecholato (DTB), has higher stability compared to simpler catecholato complexes. Three new chloro-substituted Schiff base complexes of vanadium(V) with substituted catecholates as co-ligands were synthesized for comparison with their non-chlorinated Schiff base vanadium complexes, and their properties were characterized. Up to four geometric isomers for each complex were identified in organic solvents using 51 V and 1 H NMR spectroscopies. Spectroscopy was used to characterize the structure of the major isomer in solution and to demonstrate that the observed isomers are exchanged in solution. All three chloro-substituted Schiff base vanadium(V) complexes with substituted catecholates were also characterized by UV−vis spectroscopy, mass spectrometry, and electrochemistry. Upon testing in human glioblastoma multiforme (T98g) cells as an in vitro model of brain gliomas, the most sterically hindered, hydrophobic, and stable compound [t 1/2 (298 K) = 15 min in cell medium] was better than the two other complexes (IC 50 = 4.1 ± 0.5 μM DTB, 34 ± 7 μM 3-MeCat, and 19 ± 2 μM Cat). Furthermore, upon aging, the complexes formed less toxic decomposition products (IC 50 = 9 ± 1 μM DTB, 18 ± 3 μM 3-MeCat, and 8.1 ± 0.6 μM Cat). The vanadium complexes with the chloro-substituted Schiff base were more hydrophobic, more hydrolytically stable, more easily reduced compared to their corresponding parent counterparts, and the most sterically hindered complex of this series is only the second non-innocent vanadium Schiff base complex with a potent in vitro anticancer activity that is an order of magnitude more potent than cisplatin under the same conditions.

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Section: Resultssupporting

confidence: 52%

Vanadium Chloro-Substituted Schiff Base Catecholate Complexes are Reducible, Lipophilic, Water Stable, and Have Anticancer Activities

et al. 2022

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“…Bioactive ceramics hydroxyapatites coatings on metallic implants [177][178][179] fluorapatite-based composites bone applications [180] bioactive glasses bone substitute and drug carrier [181] bioactive glass ceramics chemo hyperthermia [182] Biodegradable (bioresorbable)ceramics aluminium-calcium phosphate biomedical application [183] zinc-calcium phosphorous oxides postoperative tumour treatment [184] zinc-sulfate-calcium phosphates tissue engineering [185] ferric-calcium phosphorous oxides scaffolding for cell and drug delivery [186] coralline drugs [187] calcium aluminates bioactive dental materials [188] Bioinert (nonresorbable) ceramics alumina drug delivery [189] zirconia biomedical applications [190] carbons biomedical applications for tissue engineering [191] silicon nitride biomedical applications in medical implants [192]…”

Section: Bioceramics Examples Applications Referencesmentioning

confidence: 99%

Section: Bioceramics Examples Applications Referencesmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.

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“…Among all nanomaterials include those made of ZnO, CuO, Fe 2 O 3 , V 2 O 5 , MoO 3 , and WO 3 , among others. In comparison to other metal oxide nanostructures mentioned, only limited research has been done on vanadium oxide (V 2 O 5 ) in biomedical applications. − A wide range of cutting-edge biomedical applications has made use of the special qualities of metal oxide nanostructures, including drug delivery, in vitro and in vivo bioimaging, biosensing, cancer therapy, diagnostics, and photoinduced therapy . The application of nanotechnology in the field of biomedicine has been made easier by recent developments in the sector.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials Based Multifunctional Bioactivities of V₂O₅ and Mesoporous Carbon@V₂O₅ Composite: Preparation and Characterization

Bhosale,

Dhavale

et al. 2024

Langmuir

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Nanocarriers have attracted considerable interest due to their prospective applications in the delivery of anticancer medications and their distinct bioactivities. Biogenic nanostructures can be effective nanocarriers for delivering drugs as a consequence of sustainable and biodegradable biomassderived nanostructures that perform specific functions. In this case, a vanadium oxide (V 2 O 5 ) and mesoporous carbon@V 2 O 5 (C@V) composite was developed as a possible drug delivery system, and its bioactivities, including antioxidant, antibacterial, and anticancer, were investigated. Doxorubicin (DOX), an anticancer drug, was introduced to the nanoparticles, and the loading and release investigation was conducted. Strong interfacial interactions between mesoporous carbon (MC) and V 2 O 5 nanostructures have been found to improve performance in drug loading and release studies and bioactivities. After incubation, the potent anticancer effectiveness was seen based on C@V nanocomposite. This sample was also utilized to research potential biomedical uses as an antioxidant, antibacterial, and anticancer. The most effective antioxidant, the C@V sample (61.2%), exhibited a higher antioxidant activity than the V-2 sample (44.61%). The C@V sample ultimately attained a high DOX loading efficacy of 88%, in comparison to a pure V 2 O 5 sample (V-2) loading efficacy of 80%. Due to the combination of mesoporous carbon and V 2 O 5 , which increases specific surface area and surface sites of action as well as the morphology, it proved that the mesoporous carbon@V 2 O 5 composite (C@V) sample demonstrated greater efficacy.

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The effect of vanadium ferrite doping on the bioactivity of mesoporous bioactive glass-ceramics

Abstract: Bioactive glasses are highly reactive surface materials synthesized by melting or sol–gel techniques.

Cited by 7 publications

References 65 publications

Vanadium Chloro-Substituted Schiff Base Catecholate Complexes are Reducible, Lipophilic, Water Stable, and Have Anticancer Activities

Vanadium Chloro-Substituted Schiff Base Catecholate Complexes are Reducible, Lipophilic, Water Stable, and Have Anticancer Activities

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Nanomaterials Based Multifunctional Bioactivities of V₂O₅ and Mesoporous Carbon@V₂O₅ Composite: Preparation and Characterization

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The effect of vanadium ferrite doping on the bioactivity of mesoporous bioactive glass-ceramics

Abstract: Bioactive glasses are highly reactive surface materials synthesized by melting or sol–gel techniques.

Cited by 7 publications

References 65 publications

Vanadium Chloro-Substituted Schiff Base Catecholate Complexes are Reducible, Lipophilic, Water Stable, and Have Anticancer Activities

Vanadium Chloro-Substituted Schiff Base Catecholate Complexes are Reducible, Lipophilic, Water Stable, and Have Anticancer Activities

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Nanomaterials Based Multifunctional Bioactivities of V2O5 and Mesoporous Carbon@V2O5 Composite: Preparation and Characterization

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Product

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Nanomaterials Based Multifunctional Bioactivities of V₂O₅ and Mesoporous Carbon@V₂O₅ Composite: Preparation and Characterization