Superoxide dismutase depletion and lipid peroxidation in rat liver microsomal membranes: correlation with liver carcinogenesis

Bartoli, Gianna Maria; Giannattasio, Bartolo; Palozza, Paola; Cittadini, Achille

doi:10.1016/0304-4165(88)90114-6

Cited by 27 publications

(4 citation statements)

References 21 publications

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“…The antioxidant efficiency was examined in microsomal membranes of rat liver . These are made up of phospholipids with a high content of polyunsaturated fatty acids and represent the ideal substrate in the process of lipid peroxidation.…”

Section: Methodssupporting

confidence: 90%

Multifunctional membranes based on natural polymers: preparation, characterization and in vitro performance evaluation

et al. 2014

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The aim of this study was to synthesize new multifunctional biopolymers via esterification of hemp fibres with two reagents: meso-2,3-dimercaptosuccinic acid and ethylenediaminetetraacetic acid. The obtained biopolymers were characterized using infrared spectroscopy. The antibacterial activity of the derivative containing ethylenediaminetetraacetic acid moiety was evaluated by assessing the growth inhibition of Pseudomonas aeruginosa in Petri dishes. The results suggest that this biomaterial exhibits an excellent in vitro antibacterial activity. The antioxidant activity of the biopolymer from meso-2,3-dimercaptosuccinic acid was tested in rat liver microsomal membranes in the presence of tert-butylhydroperoxide as free radical source. Results suggest that this material inhibits lipid peroxidation induced by the free radical species. Both derivatives were used to prepare multifunctional membranes that were characterized and tested indicating the maintenance of biopolymer functionalized properties. Moreover, these functionalized biopolymers interact with metal ions due to their chelating functional groups. The absorption capacity for a selected metal ion, Cd(II), was investigated in aqueous solutions at pH = 0.65, 4.1 and 7.0 using optical emission spectroscopy. This study demonstrates that these new materials are very effective in chelating cadmium ions showing maximum efficiency at pH = 7.0.

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Section: Methodssupporting

confidence: 90%

Multifunctional membranes based on natural polymers: preparation, characterization and in vitro performance evaluation

et al. 2014

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“…Balevska et al (3) reported that when adult rats were fed Cu-deficient diets for 4 wk, there was an increase in hepatic mitochondrial and microsomal lipid peroxidation (as estimated by the formation of lipid hydroperoxides), which was attributed to Cu deficiency-induced reductions in GSH-Px. Subsequent to the work by Balevska et al, other investigators have reported both increased and decreased levels of lipid peroxidation in Cu-deficient animals (4,23,39). For example, Paynter (39) did not find evidence of increased lipid peroxidation (as estimated by thiobarbituric acid reacting substances (TBARS» in rats that were fed diets deficient in Cu but adequate in Se and Mn.…”

Section: Functional Significance Of Cu Deficiency-induced Changes In mentioning

confidence: 92%

Essential Trace Elements in Antioxidant Processes

Zidenberg‐Cherr¹,

Keen²

1991

Trace Elements, Micronutrients, and Free Radicals

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The antioxidant defense system is comprised of a number of interconnecting, and overlapping, components that include both enzymatic and nonenzymatic factors. The trace elements eu, Zn, and Mn are critical components for a number of these processes, and a deficiency of anyone of these elements can result in an impairment of the functioning of the overall antioxidant system. This impairment can be physiologically significant, particularly if the animal is exposed to environmental challenges that increase the production of oxygen radicals over normal physiological levels.

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“…In order to evaluate the antioxidant activity, pro-prodrug 4 was submitted to studies, aimed at the evaluation of malondialdehyde (MDA) formation, using rat liver microsomal membranes [ 30 ]. These, being make up of phospholipids, with a high content of polyunsaturated fatty acids are an ideal substrate for the lipid peroxidation process.…”

Section: Methodsmentioning

confidence: 99%

A New Pro-Prodrug Aminoacid-Based for Trans-Ferulic Acid and Silybin Intestinal Release

Trombino

Ferrarelli

Cassano

2014

JFB

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The aim of this work was the preparation and characterization of a pro-prodrug able to simultaneously transport silybin, a drug possessing various pharmacological effects, and trans-ferulic acid, a known antioxidant. More specifically, l-phenylalanine-N-(4-hydroxy-3-methoxy-phenyl) prop-2-en-O-(2R,3R)-3,5,7-trihydroxy-2-((2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-benzo-(1,4)-dioxin-6-yl)croman-4-one was synthesized by using the aminoacid l-phenylalanine (l-Phe) as carrier. Indeed, l-Phe is characterized by an intrinsic chemical reactivity due to the presence of an amino group, placed on the chiral center, and of a carboxylic group. The synthesis has been characterized first by adding silybin by means of carboxylic group and then, with the aim to confer antioxidant properties to this new carrier, by linking trans-ferulic acid to l-Phe via amino group. The so obtained derivative was then characterized by FT-IR, and 1H-NMR spectroscopies. Furthermore, its ability to inhibit lipid peroxidation induced by tert-butyl hydroperoxide in rat liver microsomes, was evaluated. The 1,1-diphenyl-2-picrylhydrazyl radical-scavenging effect, was also assessed. The release of silybin and trans-ferulic acid was determined in simulated gastric and intestinal fluids over the time. The results showed that the covalent bond between both (i) silybin; or (ii) trans-ferulic acid and the amino acid was degraded by enzymatic reactions. In addition, the pro-prodrug, showed strong antioxidant and scavenger activities. Due to these properties, this new pro-prodrug could be applied for the treatment of intestinal pathologies and it might improve the therapeutic potential of silybin which is strongly limited by its low solubility.

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Superoxide dismutase depletion and lipid peroxidation in rat liver microsomal membranes: correlation with liver carcinogenesis

Cited by 27 publications

References 21 publications

Multifunctional membranes based on natural polymers: preparation, characterization and in vitro performance evaluation

Multifunctional membranes based on natural polymers: preparation, characterization and in vitro performance evaluation

Essential Trace Elements in Antioxidant Processes

A New Pro-Prodrug Aminoacid-Based for Trans-Ferulic Acid and Silybin Intestinal Release

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