Multifunctional membranes based on natural polymers: preparation, characterization and <i>in vitro</i>
 performance evaluation

Trombino, Sonia; Poerio, Teresa; Ferrarelli, Teresa; Mauro, Maria Vittoria; Giraldi, Cristina; Giorno, Lidietta; Cassano, Roberta

doi:10.1002/pi.4844

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…The samples were then incubated with the microsomal suspension in a thermostatic bath at 37 °C for 24 h. At specific time intervals (0 min, 15 min, 30 min, 1 h and 2 h) the samples were withdrawn, heated at 90 °C and then centrifugated. Subsequently, the thiobarbituric-acid–malondialdehyde complex (pink color chromogen) was spectrophotometrically detected at λ = 535 nm [ 27 , 28 , 29 , 30 ].…”

Section: Methodsmentioning

confidence: 99%

Production of α-Tocopherol–Chitosan Nanoparticles by Membrane Emulsification

et al. 2022

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α-tocopherol (α-T) has the highest biological activity with respect to the other components of vitamin E; however, conventional formulations of tocopherol often fail to provide satisfactory bioavailability due to its hydrophobic characteristics. In this work, α-tocopherol-loaded nanoparticles based on chitosan were produced by membrane emulsification (ME). A new derivative was obtained by the cross-linking reaction between α-T and chitosan (CH) to preserve its biological activity. ME was selected as a method for nanoparticle production because it is recognized as an innovative and sustainable technology for its uniform-particle production with tuned sizes and high encapsulation efficiency (EE%), and its ability to preserve the functional properties of bioactive ingredients operating in mild conditions. The reaction intermediates and the final product were characterized by 1HNMR, Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC), while the morphological and dimensional properties of the nanoparticles were analyzed using electronic scanning microscopy (SEM) and dynamic light scattering (DLS). The results demonstrated that ME has high potential for the development of α-tocopherol-loaded nanoparticles with a high degree of uniformity (PDI lower than 0.2), an EE of almost 100% and good mechanical strength, resulting in good candidates for the production of functional nanostructured materials for drug delivery. In addition, the chemical bonding between chitosan and α-tocopherol allowed the preservation of the antioxidant properties of the bioactive molecule, as demonstrated by an enhanced antioxidant property and evaluated through in vitro tests, with respect to the starting materials.

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Section: Methodsmentioning

confidence: 99%

Production of α-Tocopherol–Chitosan Nanoparticles by Membrane Emulsification

et al. 2022

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“…Since then, these applications have become common in many applications and markets [ 1 ] and, in particular, polymer membrane technologies have expanded to practically every industrial sector including environmental, electronic or biotechnological ones [ 2 ]. Some of the most important membrane applications include batteries [ 3 , 4 , 5 ], fuel cells [ 6 , 7 ], filtration [ 8 , 9 ], air filtration [ 10 , 11 ], water treatment [ 12 , 13 , 14 ], agriculture [ 15 , 16 ], pharmacy [ 17 , 18 ], tissue engineering [ 19 , 20 ], biomedical applications [ 21 , 22 ], among others.…”

Section: Introductionmentioning

confidence: 99%

Effect of Polymer Dissolution Temperature and Conditioning Time on the Morphological and Physicochemical Characteristics of Poly(Vinylidene Fluoride) Membranes Prepared by Non-Solvent Induced Phase Separation

et al. 2021

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This work reports on the production of poly(vinylidene fluoride) (PVDF) membranes by non-solvent induced phase separation (NIPS) using N,N-dimethylformamide (DMF) as solvent and water as non-solvent. The influence of the processing conditions in the morphology, surface characteristics, structure, thermal and mechanical properties were evaluated for polymer dissolution temperatures between 25 and 150 °C and conditioning time between 0 and 10 min. Finger-like pore morphology was obtained for all membranes and increasing the polymer dissolution temperature led to an increase in the average pore size (≈0.9 and 2.1 µm), porosity (≈50 to 90%) and water contact angle (up to 80°), in turn decreasing the β PVDF content (≈67 to 20%) with the degree of crystallinity remaining approximately constant (≈56%). The conditioning time did not significantly affect the polymer properties studied. Thus, the control of NIPS parameters proved to be suitable for tailoring PVDF membrane properties.

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“…Polysulfone (PSf) is one of the most well‐known polymeric materials and is widely used as the base material in hemodialysis membranes . PSf‐based membranes show good heat resistance, physiochemical stability, oxidative stress tolerance and chemical compatibility resistance over a wide range of pH .…”

Section: Introductionmentioning

confidence: 99%

Enhanced hydrophilic polysulfone hollow fiber membranes with addition of iron oxide nanoparticles

et al. 2017

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Membranes are at the heart of hemodialysis treatment functions to remove excess metabolic waste such as urea. However, membranes made up of pure polymers and hydrophilic polymers such as polyvinylpyrrolidone suffer problems of low flux and bio-incompatibility. Hence, this study aimed to improve polysulfone (PSf) membrane surface properties by the addition of iron oxide nanoparticles (IONPs). The membrane surface properties and separation performance of neat PSf membrane and membrane filled with IONPs at a loading of 0.2 wt% were investigated and compared. The membranes were characterized in terms of morphology, pure water permeability (PWP) and protein rejection using bovine serum albumin (BSA). A decrease in contact angle value from 66.62 ∘ to 46.23 ∘ for the PSf/IONPs membrane indicated an increase in surface hydrophilicity that caused positive effects on the PWP and BSA rejection of the membrane. The PWP increased by 40.74% to 57.04 L m −2 h −1 bar −1 when IONPs were incorporated due to the improved interaction with water molecules. Furthermore, the PSf/IONPs membrane rejected 96.43% of BSA as compared to only 91.14% by the neat PSf membrane. Hence, the incorporation of IONPs enhanced the PSf hollow fiber membrane hydrophilicity and consequently improved the separation performance of the membrane for hemodialysis application.

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Multifunctional membranes based on natural polymers: preparation, characterization and in vitro performance evaluation

Cited by 5 publications

References 28 publications

Production of α-Tocopherol–Chitosan Nanoparticles by Membrane Emulsification

Production of α-Tocopherol–Chitosan Nanoparticles by Membrane Emulsification

Effect of Polymer Dissolution Temperature and Conditioning Time on the Morphological and Physicochemical Characteristics of Poly(Vinylidene Fluoride) Membranes Prepared by Non-Solvent Induced Phase Separation

Enhanced hydrophilic polysulfone hollow fiber membranes with addition of iron oxide nanoparticles

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