Essential Trace Elements in Antioxidant Processes

Zidenberg‐Cherr, Sheri; Keen, Carl L.

doi:10.1007/978-1-4612-0419-0_5

Cited by 22 publications

(8 citation statements)

References 54 publications

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“…This alteration may be, at least partly, owing to the marked decrease of erythrocyte metal ions. Indeed, the association between trace element levels and antioxidant defence is well known [54] and is also supported by our results. Probably the more marked changes in antioxidant status detected in women compared with men are attributable to more marked changes in their trace element levels.…”

Section: Discussionsupporting

confidence: 87%

Sex-dependent alterations in erythrocyte trace element levels and antioxidant status after a month of moderate daily red wine consumption

Bekő¹,

Hagymási²,

Szentmihályi³

et al. 2010

European Journal of Gastroenterology &Amp; Hepatology

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Although no hepatotoxicity was observed, changes in trace element content were detected after 1 month of moderate red wine consumption. The most remarkable sex-specific alteration was the decrease of Zn levels and of the Zn/Cu ratio in women. Given the protective effect of Zn against liver damage, this finding suggests a possible contribution of decreased Zn levels to sex-dependent effects of red wine.

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Section: Discussionsupporting

confidence: 87%

Sex-dependent alterations in erythrocyte trace element levels and antioxidant status after a month of moderate daily red wine consumption

Bekő¹,

Hagymási²,

Szentmihályi³

et al. 2010

European Journal of Gastroenterology &Amp; Hepatology

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“…In addition, the Cudeficient embryos may have experienced membrane damage, but because of changes in the fatty acid profile of the membrane, such changes may have gone undetected. Alterations in the fatty acid profile of select tissues in response to oxidative insults in adult tissues is well recognized [48]. What has not been determined is whether the type or amount of embryonic polyunsaturated fatty acid can be influenced by elevated oxidative pressure.…”

Section: Discussionmentioning

confidence: 99%

Copper-Deficient Rat Embryos Are Characterized by Low Superoxide Dismutase Activity and Elevated Superoxide Anions1

Hawk

Lanoue

Keen

et al. 2003

Biology of Reproduction

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The teratogenicity of copper (Cu) deficiency may result from increased oxidative stress and oxidative damage. Dams were fed either control (8.0 microg Cu/g) or Cu-deficient (0.5 microg Cu/g) diets. Embryos were collected on Gestational Day 12 for in vivo studies or on Gestational Day 10 and cultured for 48 h in Cu-deficient or Cu-adequate media for in vitro studies. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione reductase (GR) activities were measured in control and Cu-deficient embryos as markers of the oxidant defense system. Superoxide anions were measured as an index of exposure to reactive oxygen species (ROS). No differences were found in GPX or GR activities among treatment groups. However, SOD activity was lower and superoxide anion concentrations higher in Cu-deficient embryos cultured in Cu-deficient serum compared to control embryos cultured in control serum. Even so, Cu-deficient embryos had similar CuZnSOD protein levels as controls. In the in vitro system, Cu-deficient embryos had a higher frequency of malformations and increased staining for superoxide anions in the forebrain, heart, forelimb, and somites compared to controls. When assessed for lipid and DNA oxidative damage, conjugated diene concentrations were similar among the groups, but a tendency was observed for Cu-deficient embryos to have higher 8-hydroxy-2'-deoxyguanosine concentrations than controls. Thus, Cu deficiency resulted in embryos with malformations and reduced SOD enzyme activity. Increased ROS concentrations in the Cu-deficient embryo may cause oxidative damage and contribute to the occurrence of developmental defects.

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“…Trace minerals also mitigate the inflammatory response [43], perhaps because they play a major role in the anti-oxidation of free radicals [44]. Further, manganese has been found deficient in bronchial biopsies of asthmatic patients, indication manganese replenishment could aid in the treatment of asthma.…”

Section: Discussionmentioning

confidence: 99%

Short and long term treatment of asthma with intravenous nutrients

Shrader¹

2004

Nutr J

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acute asthmachronic asthmaintravenous nutrientsintravenous vitaminsintravenous magnesiumintravenous molybdenumintravenous vitamin B-12pulmonary function testing (PFT)spirometry. AbstractBackground: Asthma is an increasing problem in this country and others. Although medications for the treatment of asthma abound and are improving, there are inherent risks and side effects with all of them. Intravenous magnesium has been employed in the treatment of acute asthma, but its use has not become universal, nor has it been studied for the treatment of chronic asthma. It is known to be a safe drug with minimal side effects. In this study, the author investigates the use of magnesium and other nutrients in the treatment of both acute and chronic asthma.

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Essential Trace Elements in Antioxidant Processes

Cited by 22 publications

References 54 publications

Sex-dependent alterations in erythrocyte trace element levels and antioxidant status after a month of moderate daily red wine consumption

Sex-dependent alterations in erythrocyte trace element levels and antioxidant status after a month of moderate daily red wine consumption

Copper-Deficient Rat Embryos Are Characterized by Low Superoxide Dismutase Activity and Elevated Superoxide Anions1

Short and long term treatment of asthma with intravenous nutrients

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