Superficial papillary urothelial carcinomas in young and elderly patients: a comparative study

Abstract

surgery only patients diagnosed with pT1 tumours were treated by intravesical bacille Calmette-Guérin (BCG) instillations; all received intravesical BCG if there was a recurrence. The clinicopathological variables, recurrence and disease-free interval to recurrence were assessed. Proliferative activity (MIB-1) and expression of cell-cycle regulation proteins cyclin D1, p53 and p27 kip1 were detected by immunohistochemistry in the tumours of both groups.

Clinicopathologic Comparison of Urothelial Bladder Carcinoma in Young and Elder Patients

“…Interestingly, the opposite result was also reported. Migaldi et al have reported that women constituted 32 % of patients with age less than 45 years and 12 % amongst elderly patients aged ≥ 45 [8].However, in our study, We have not found any difference in gender distribution between younger and elder groups which is not in line with studies mentioned above. We have to point out that due to the fact that younger patients only account for a small part in all the studies, including our study, thus, it is difficult to conclude whether gender distribution in the two groups is different or not.…”

“…UBCs is typically a disease of older individuals, with the median age of the first diagnosis 69 and 71 years old for males and females respectively, and rarely occurs below the age of 40 years [7]. There is debate and uncertainty regarding the clinicopathologic characteristics of UBCs in younger patients [8][9][10][11][12][13]. Some studies reported a more favorable prognosis in young patients compared to old patients [14]; while other studies showed similar clinical course of UBCs in young and old patient groups [9,11].…”

Profil évolutif et pronostic des tumeurs urothéliales de la vessie chez le sujet jeune

“…Tumeurs urothéliales de la vessie chez les jeunes 1,5,6,[17][18][19] . L'aspect évolutif des TVNIM survenant entre 30 et 40 ans tend à se rapprocher de celui qui est noté chez les sujets âgés.…”

“…L'atteinte chez le jeune adulte (moins de 40 ans) est rare et ne dépasse pas 4 % selon les séries 1,2,[4][5][6][7] . L'évolution naturelle et le pronostic du carcinome à cellules transitionnelles (CCT) de la vessie chez les jeunes patients restent un sujet de débat et peu de données ont été publiées concernant cette entité.…”

“…De plus, les quelques études ayant analysé le pronostic du cancer de la vessie dans cette population ont abouti à des résultats contradictoires. Certains auteurs considèrent que 30 ans est un âge charnière au-delà duquel l'agressivité de la tumeur urothéliale de la vessie rejoint celle du sujet âgé, et en deçà duquel le pronostic est meilleur 1,3,[6][7][8][9] . Dans cette étude, on s'est proposé de déterminer le profil évolutif et le pronostic des tumeurs urothéliales de la vessie chez le jeune adulte.…”