Supercritical impregnation of intraocular lenses

Drug loading of polymer implants by supercritical CO 2 assisted impregnation: A review

“…Opposite effects of temperature on drug loading were noticed. The drug loading was found either to increase [27,43,47,52,53], to decrease [35,46], to be constant [62], or to first decrease and then increase [48] with temperature under isobaric conditions.…”

“…In those cases, not only the {CO 2 + drug}, {drug + polymer} and {CO 2 + polymer} systems must be taken into account, but also the influence of the cosolvent on the behaviors and the interactions. It is well-known that the solubility of drug in CO 2 is raised by cosolvent but the CO 2 sorption and the swelling can also increase if the polymer-CO 2 /cosolvent interactions are favored [53,61]. The drug loading of tranilast into PLLA may increase for those two reasons; although the impact of EtOH on drug solubility and on the polymer behavior had not been studied [47].…”

Intra-ocular lens optical changes resulting from the loading of dexamethasone

“…One way of solving this problem is based on developing a new generation of intraocular lenses (IOL) loaded with ophthalmic drugs that release the postoperative treatment into the eye [5][6][7][8][9][10] in a sustained and controlled way. This could eliminate the need for topical treatment and the risks associated with inadequate treatment compliance; it also increases the effectiveness of the medication as there is a constant and controlled intraocular release of the drugs.…”

Chitosan/alginate based multilayers to control drug release from ophthalmic lens

“…The efforts made by many researchers in the last decades to optimize drug delivery through soft contact lenses (SCLs) have been described in several recent reviews [1][2][3]. In the case of cataracts which are, nowadays, one of the most frequent eye diseases, other devices have been investigated to prevent postoperative infectious complications after surgery, namely, therapeutic intraocular lenses (IOLs) [4][5][6].…”