Chitosan/alginate based multilayers to control drug release from ophthalmic lens

Silva, Diana; Pinto, L. F. V.; Bozukova, Dimitriya; Santos, Luı́s F.; Serro, Ana Paula

doi:10.1016/j.colsurfb.2016.07.047

Cited by 72 publications

(32 citation statements)

References 54 publications

(55 reference statements)

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“…In previous studies, the gelatinization of CS was usually performed at high temperature such as 76°C in a boiling water bath [], 60°C for 24 hours [], or 80°C for 3.5 hours []. Indeed, such high‐temperature polymerization is the easiest method of obtaining regular CS hydrogel.…”

Section: Discussionmentioning

confidence: 99%

Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model

Tao

Guo

et al. 2016

Stem Cells Translational Medicine

300

256

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There is a need to find better strategies to promote wound healing, especially of chronic wounds, which remain a challenge. We found that synovium mesenchymal stem cells (SMSCs) have the ability to strongly promote cell proliferation of fibroblasts; however, they are ineffective at promoting angiogenesis. Using gene overexpression technology, we overexpressed microRNA‐126‐3p (miR‐126‐3p) and transferred the angiogenic ability of endothelial progenitor cells to SMSCs, promoting angiogenesis. We tested a therapeutic strategy involving controlled‐release exosomes derived from miR‐126‐3p‐overexpressing SMSCs combined with chitosan. Our in vitro results showed that exosomes derived from miR‐126‐3p‐overexpressing SMSCs (SMSC‐126‐Exos) stimulated the proliferation of human dermal fibroblasts and human dermal microvascular endothelial cells (HMEC‐1) in a dose‐dependent manner. Furthermore, SMSC‐126‐Exos also promoted migration and tube formation of HMEC‐1. Testing this system in a diabetic rat model, we found that this approach resulted in accelerated re‐epithelialization, activated angiogenesis, and promotion of collagen maturity in vivo. These data provide the first evidence of the potential of SMSC‐126‐Exos in treating cutaneous wounds and indicate that modifying the cells—for example, by gene overexpression—and using the exosomes derived from these modified cells provides a potential drug delivery system and could have infinite possibilities for future therapy. Stem Cells Translational Medicine 2017;6:736–747

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Section: Discussionmentioning

confidence: 99%

Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model

Tao

Guo

et al. 2016

Stem Cells Translational Medicine

300

256

View full text Add to dashboard Cite

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“…This would be possible if by any chance the chitosan is distributed inward the dispersion particles upon measurement. Similarly as in the study by Silva and his colleagues (Silva, et al, 2016), the alginate is oriented towards the surface of the multilayer chitosan/alginate nanocapsule. Additionally, the NPK fertilizer utilized in this study is in the form of ions which may cause the phosphate groups interact to the excess chitosan molecules creating a negative surface charge.…”

Section: Zeta Potential Measurements Of the Coated Chitosan/alginate mentioning

confidence: 66%

Coated NPK Fertilizer Based on Citric Acid-Crosslinked Chitosan/Alginate Encapsulant

Mesias¹,

Agu²,

Benablo³

et al. 2019

J. Ecol. Eng.

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A coated nitrogen-phosphorus-potassium (NPK) fertilizer was prepared via crosslinking chitosan and alginate using citric acid. Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), particle size analysis, and zeta potential measurement showed the successful crosslinking, appropriate size, and colloidal stability of the coated NPK fertilizer. The encapsulation capability of the crosslinked chitosan/alginate (Chi/Alg) was studied using fluorescence spectroscopy and NPK analysis. The release behavior studies under various pH conditions showed that Chi/Alg NPK conformed to the standards of controlled release fertilizer with a maximum release rate of 40% for 30 days. The investigation of the release mechanism using Korsemeyer-Peppas mathematical model showed that the release of nutrients is governed by both coating material relaxation and diffusion process.

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“…This polymer is one of the most widely used for biomedical applications. Actually, chitosan has been under investigation for drug and vaccine delivery (Borges et al, 2008;Esmaeili et al, 2010;Jafary Omid et al, 2018;Bento et al, 2019), gene delivery (Thanou et al, 2002), surgical sutures (Muzzarelli et al, 1993;Altinel et al, 2018), rebuilding of bone (Lee et al, 2009), corneal contact lenses (Silva et al, 2016), dental implants (Yokoyama et al, 2002), wound healing (Mizuno et al, 2003), antimicrobial applications (Dai et al, 2009), and tissue engineering (Madihally and Matthew, 1999;Kanimozhi et al, 2016). Moreover, chitosan has been used as a dietary supplement in preparations for treatment of obesity and hypercholesterolemia (Bokura and Kobayashi, 2003;Zhang et al, 2008) and also in medical devices for the treatment and control of bleeding (Millner et al, 2009).…”

Section: Chitosan: Potential and Versatilitymentioning

confidence: 99%

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Marques

Som

Schmutz

et al. 2020

Front. Bioeng. Biotechnol.

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Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.

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Chitosan/alginate based multilayers to control drug release from ophthalmic lens

Cited by 72 publications

References 54 publications

Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model

Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model

Coated NPK Fertilizer Based on Citric Acid-Crosslinked Chitosan/Alginate Encapsulant

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

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