Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.
et al. Replaning the singular therapeutic design (pts) to children and adolescents users of alcohol-drug caps of the municipality of são bernardo do campo.
Introduction: Pressure ulcer cushions are specialised devices for pressure redistribution and management of tissue load and microclimate. They should maintain postural alignment, facilitate movement, create a stable base, relieve pain and be comfortable. They can be composed exclusively of one material such as foam, gel, air and fluid, or a combination of two or more of these materials. Research has focused on weight distribution and has neglected the dynamic behaviour of the cushion during everyday activities. Objectives: To evaluate the effectiveness in maintaining dynamic balance of three types of medium-high range cushions with different compositions. Material and Methods: Study with a female person with Girdle-Limb Muscular Dystrophy, using: a foam and air cushion (A), a foam and fluid bag cushion (B) and an air cushion (C). Data were collected in two moments: 1) anthropometric, kinematic and dynamic data collection, through direct measurement of reach, video recording and accelerometer, and pressures exerted on the cushions, employing a protocol of movements and cushion randomisation; 2) evaluation of user perception with a questionnaire and visual analogue pain scale, after four hours of staying on the cushion. Results: Cushion A revealed better results at the level of maximum reach, peak pressure in the initial position, coefficient of variation and mean pressure in frontal trunk flexion. Cushion B showed more positive results in the contact area, coefficient of variation and mean pressure in the initial position, peak pressure in frontal trunk flexion, acceleration variation and subjective analysis. Conclusion: The anti-sores cushions that combine two materials in their composition are more effective in promoting dynamic balance, with the advantage of the cushion composed of foam and fluid.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.