Intra-ocular lens optical changes resulting from the loading of dexamethasone

Artigas, José María Gatell; García-Domene, Mari Carmen; Navea, Amparo; Botella, Pablo; Fernández, Eduardo

doi:10.1364/boe.8.004621

Cited by 2 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the incorporation of drugs like DEX into IOLs is not without drawbacks. Artigas et al have shown that pHEMA-silicone IOLs loaded with DEX can compromise the lens’s optical properties [ 162 ]. Furthermore, a pertinent clinical consideration arises for patients known as steroid responders, who exhibit an elevated IOP when exposed to steroids.…”

Section: Utilization Of Hydrogels In Intraocular Lens Technologymentioning

confidence: 99%

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges

Wu,

Akbar,

Giunta

et al. 2023

Materials

View full text Add to dashboard Cite

The human eye’s intricate anatomical and physiological design necessitates tailored approaches for managing ocular diseases. Recent advancements in ophthalmology underscore the potential of hydrogels as a versatile therapeutic tool, owing to their biocompatibility, adaptability, and customizability. This review offers an exploration of hydrogel applications in ophthalmology over the past five years. Emphasis is placed on their role in optimized drug delivery for the posterior segment and advancements in intraocular lens technology. Hydrogels demonstrate the capacity for targeted, controlled, and sustained drug release in the posterior segment of the eye, potentially minimizing invasive interventions and enhancing patient outcomes. Furthermore, in intraocular lens domains, hydrogels showcase potential in post-operative drug delivery, disease sensing, and improved biocompatibility. However, while their promise is immense, most hydrogel-based studies remain preclinical, necessitating rigorous clinical evaluations. Patient-specific factors, potential complications, and the current nascent stage of research should inform their clinical application. In essence, the incorporation of hydrogels into ocular therapeutics represents a seminal convergence of material science and medicine, heralding advancements in patient-centric care within ophthalmology.

show abstract

Section: Utilization Of Hydrogels In Intraocular Lens Technologymentioning

confidence: 99%

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges

Wu,

Akbar,

Giunta

et al. 2023

Materials

View full text Add to dashboard Cite

show abstract

A Critical Appraisal of New Developments in Intraocular Lens Modifications and Drug Delivery Systems for the Prevention of Cataract Surgery Complications

Mylona

Tsinopoulos

2020

Pharmaceuticals

View full text Add to dashboard Cite

Cataract surgery is the commonest ophthalmic surgery worldwide. The replacement of the diseased lens with a synthetic one (intraocular lens—IOL) remains the treatment of choice, despite its potential complications that include infection, inflammation and posterior capsule opacification. The potential for drug delivery via the IOL has been researched extensively over a period of twenty-five years, yet there is very limited progress in transferring the findings from research to everyday practice. The objective of this review is to assess the progress made in the field of IOL lens modifications and drug delivery systems over the past five years. Thirty-six studies that were conducted during the past five years were identified and deemed suitable for inclusion. They were grouped in three broad categories, studies that described new methods for loading a drug onto the IOL, assessment of the effects of drugs that were loaded to the IOL and studies that assessed the effects of non-pharmaceutical modifications of IOLs. While considerable progress is continually being made with regard to methods and materials, there is still little capitalization upon these research studies, with no commercially available IOL-based drug delivery system being available. Close cooperation between researchers in basic sciences (chemistry, physics, materials science and pharmacy), clinical researchers, IOL manufacturers and the pharmaceutical industry is an important prerequisite for further development.

show abstract

Intra-ocular lens optical changes resulting from the loading of dexamethasone

Cited by 2 publications

References 21 publications

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges

A Critical Appraisal of New Developments in Intraocular Lens Modifications and Drug Delivery Systems for the Prevention of Cataract Surgery Complications

Contact Info

Product

Resources

About