2013
DOI: 10.2967/jnumed.112.116624
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99mTc-Labeled Small-Molecule Inhibitors of Prostate-Specific Membrane Antigen for Molecular Imaging of Prostate Cancer

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Cited by 198 publications
(154 citation statements)
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“…The biodistribution profiles of acetazolamide derivatives compares favourably with the ones previously reported for other ligands [23][24][25][26]. In particular, we were pleased to see that %ID/g values in the tumor were higher than the corresponding values in the kidney (the main organ for drug clearance), even as early as one hour after intravenous administration of the product [18].…”
Section: Discussionsupporting
confidence: 62%
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“…The biodistribution profiles of acetazolamide derivatives compares favourably with the ones previously reported for other ligands [23][24][25][26]. In particular, we were pleased to see that %ID/g values in the tumor were higher than the corresponding values in the kidney (the main organ for drug clearance), even as early as one hour after intravenous administration of the product [18].…”
Section: Discussionsupporting
confidence: 62%
“…Aliquots (150 μl) were taken at different time points (0, 15', 1h, 6h, 24h, 48h) and frozen at -20°C. Standard solutions of the conjugates were prepared in PBS at different concentration (25,50, 100, 150 μg/ml) and stored at -20 °C. The standards and the samples were analyzed in triplicate by Liquid Chromatography -Mass Spectrometry (LC-MS) on a Waters Xevo G2-XS QTOF coupled to a Waters Acquity UPLC H-Class System using a ACQUITY UPLC BEH C18 Column, 130 Å, 1.7 µm, 2.1 mm × 50 mm column.…”
Section: Linker Stability Assaysmentioning
confidence: 99%
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“…В дальнейшем были разработаны улучшенные вари-анты подобного РФП для радиоизотопной диагностики c 123 I и терапии с изотопами 131 I, 177 Lu и 90 Y [11,16]. Однако, несмотря на лучшие результаты доклинических и пилотных клинических исследований, по сравнению с 111 In-capromab, новые РФП не нашли клинического применения, т.к.…”
Section: простатспецифический мембранный антиген как кандидат в биомаunclassified