Sunlight Avoidance and Cancer Prevention in Xeroderma Pigmentosum

Davis, Bret E.; Koh, Howard K.; Rohrer, Thomas E.; González, Ernesto; Cleaver, James E.

doi:10.1001/archderm.1994.01690060144029

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…Patients with XP usually develop a great number of skin tumours at an early age such as basal cell carcinoma (BCC) and squamous cell carcinoma, actinic keratosis (AK), atypical moles and malignant melanoma associated with severe photoageing 10 . The prognosis in these cases depends on strict UV photoprotection, 11 and the early diagnosis and surgical treatment of skin tumours. The clinical diagnosis of skin tumours at an early stage and the discrimination between malignant lesions and benign lesions is challenging in these patients because of the presence of severe UV‐induced skin damage with the generalized presence of actinic lentigines, AKs and poikiloderma.…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive management of non‐melanoma skin cancer in patients with cancer predisposition genodermatosis: a role for confocal microscopy and photodynamic therapy

Segura

Puig

Carrera³

et al. 2010

Acad Dermatol Venereol

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Section: Introductionmentioning

confidence: 99%

Non‐invasive management of non‐melanoma skin cancer in patients with cancer predisposition genodermatosis: a role for confocal microscopy and photodynamic therapy

Segura

Puig

Carrera³

et al. 2010

Acad Dermatol Venereol

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“…2 So type are designated ERCC (excision repair crossfar, there is no effective long-term treatment available for XP patients. Some protective measures can be taken to keep patients from exposure to sunlight, 23 and skin grafts from the same patient were performed to resurface the therapeutical protocol is efficient only in the short term, complementation groups, transduced and untransduced cells were analyzed for: since skin grafts are still genetically DNA repair defective and thus cancer prone. 24 The genetic correction of XP (1 Figure 2a and genes into cells derived from XP patients.…”

Section: Introductionmentioning

confidence: 99%

Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C

et al. 1997

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With the aim to devise a long-term gene therapy protocol survival, unscheduled DNA synthesis and recovery of RNA for skin cancers in individuals affected by the inherited synthesis, and Western blots. The results show that the autosomal recessive xeroderma pigmentosum, we transrecombinant retroviruses are highly efficient vectors to ferred the human DNA repair XPA, XPB/ERCC3 and XPC transfer and stably express the human DNA repair genes cDNAs, by using the recombinant retroviral vector LXSN, in XP cells and correct the defect of DNA repair of group into primary and immortalized fibroblasts obtained from two A, B and C. With our previous results with XPD/ERCC2, XP-A, one XP-B (associated with Cockayne's syndrome) the present work extends further promising issues for the and two XP-C patients. After transduction, the complete gene therapy strategy for most patients suffering from this correction of DNA repair deficiency and functional cancer-prone syndrome. expression of the transgenes were monitored by UV

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“…Studies of special contexts (human models) have been informative (15). Even in the context of familial melanoma and of xeroderma pigmentosum, the very limited available evidence supports the link between sun exposure and cutaneous malignancy (16)(17)(18)(19)(20) A key issue for each of the three common types of skin cancers is, therefore, documentation of the action spectrum (i.e., the relation between carcinogenesis and wavelength). Epidemiologic research has not been able to document an action spectrum for any of these malignancies.…”

Section: The Linkmentioning

confidence: 99%

Overview of ultraviolet radiation and cancer: what is the link? How are we doing?

Weinstock

1995

Environ Health Perspect

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Sun exposure has now been established as the most important avoidable cause of nonmelanoma skin cancer (NMSC) and melanoma. With specific reference to melanoma, there are several key issues that remain to be resolved. These include definition of the action spectrum, the importance of systemic effects of sun exposure, whether a tan is protective, the risk of tanning booth exposures, and the efficacy of sunscreens. Also the role, if any, of sun exposure in noncutaneous malignancies remains to be established. Melanoma incidence and mortality have increased dramatically over the past several decades, but these increases have now slowed, and for mortality among those 15 to 45 years of age, decreasing rates are now observed. Improving the coverage of the Surveillance, Epidemiology, and End Results (SEER) registries by requiring pathology laboratories in non-SEER areas to report cancers among SEER area residents will allow correct interpretation of these trends in the future at minimal cost. The available data on trends in NMSC incidence and mortality are suboptimal but suggest a pattern of declining mortality despite increasing incidence. Trends in NMSC morbidity have not been defined. Establishing NMSC registries in a few diverse sentinel areas would allow more reliable inference and monitoring. Techniques are being developed for reducing sun exposures and increasing early detection of skin cancers in the general population, but improved monitoring of incidence, mortality, and morbidity is required to monitor the effects of current and future ozone depletion and to evaluate prevention and early detection measures. -Environ Health Perspect 103(Suppl 8): 251-254 (1995)

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Sunlight Avoidance and Cancer Prevention in Xeroderma Pigmentosum

Cited by 9 publications

References 9 publications

Non‐invasive management of non‐melanoma skin cancer in patients with cancer predisposition genodermatosis: a role for confocal microscopy and photodynamic therapy

Non‐invasive management of non‐melanoma skin cancer in patients with cancer predisposition genodermatosis: a role for confocal microscopy and photodynamic therapy

Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C

Overview of ultraviolet radiation and cancer: what is the link? How are we doing?

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