Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here, we report that genes involved in various human cancers evolved rapidly in Tibetans and six Tibetan domestic mammals compared to reciprocal lowlanders. Furthermore, m6A modified mRNA binding protein YTHDF1, one of evolutionary positively selected genes for high-altitude adaptation is amplified in various cancers, including non-small cell lung cancer (NSCLC). We show that YTHDF1 deficiency inhibits NSCLC cell proliferation and xenograft tumor formation through regulating the translational efficiency of CDK2, CDK4, and cyclin D1, and that YTHDF1 depletion restrains de novo lung adenocarcinomas (ADC) progression. However, we observe that YTHDF1 high expression correlates with better clinical outcome, with its depletion rendering cancerous cells resistant to cisplatin (DDP) treatment. Mechanistic studies identified the Keap1-Nrf2-AKR1C1 axis as the downstream mediator of YTHDF1. Together, these findings highlight the critical role of YTHDF1 in both hypoxia adaptation and pathogenesis of NSCLC.

Despite the substantial role that chickens have played in human societies across the world, both the geographic and temporal origins of their domestication remain controversial. To address this issue, we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl (RJF). Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China, northern Thailand and Myanmar. Following their domestication, chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species. In addition, our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF. Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls, our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral, morphological and reproductive traits. Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal.

The Last Glacial Maximum (LGM, and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. deserts and sand fields in China, Last Glacial Maximum, Holocene Optimum, OSL dating, active sand dunes Citation:

The Chinese Loess Plateau in north central China contains one of the most valuable Cenozoic climate archives on land. Establishing the origin of this substantial archive of aeolian sediments is critical for the interpretation of loess climate proxies, past atmospheric wind patterns and changing climatic/tectonic controls on erosion over potentially the past 25 Ma. Despite this significance there are a number of disagreements over the precise source areas and the extent to which these vary through time and across the plateau. To address this, we utilize a multi-technique, approach of combined detrital singlegrain zircon U-Pb dating and heavy mineral analysis to establish the sources of loess through the Quaternary and constrain their variation geographically across the Loess Plateau. We combine our data with suitable published single-grain datasets from loess and possible source regions. The results

Antihuman C5a antibody treatment remarkably reduced the ALI and systemic inflammation induced by H7N9 virus infection. Complement inhibition may be a promising adjunctive therapy for severe viral pneumonia.

In this study, we report standard quartz SAR OSL and post‐IR infrared (IR) stimulated luminescence (post‐IR IRSL; pIRIR290) measurements made on sand‐sized quartz and K‐feldspar extracts from the loess‐palaeosol sequence at Niuyangzigou in northeastern China. The quartz OSL characteristics are satisfactory. Extensive pIRIR50,290 dose recovery tests were performed by adding doses on top of the natural dose. We found that dose recovery ratios improve significantly when the test dose ranges between ~15 and ~80% of the total dose, and good dose recovery (within ±5% of unity) can be obtained up to ∼800 Gy. Otherwise, the dose recovery ratio deviates from unity. The De values also depend on the test dose size and so we conclude that the effect of test dose size should be routinely considered in pIRIR dating. First IR stimulation plateau pIRIR290 results are compared with multiple elevated temperature ‐pIRIR (MET‐pIRIR) data. It appears that the low temperature MET‐pIRIR data are strongly affected by poor dose recovery, but this is not the case for the pIRIR290 results. Natural signal measurements at the highest (first IR) stimulation temperature on a sample expected to be in field saturation suggest that ~10% signal loss occurs in pIRIR signals. Long‐term laboratory bleaching experiments (>80 days) show that a constant (or very difficult to bleach) residual pIRIR290 signal is reached after ~300 h, corresponding to a dose of 6.2±0.7 Gy. Quartz OSL and feldspar pIRIR50,290 ages are in good agreement at least back to c. 70 ka. Beyond this the quartz ages begin to underestimate but the feldspar ages are in agreement with the expected Last Interglacial age palaeosol.

Background Pistachio ( Pistacia vera ), one of the most important commercial nut crops worldwide, is highly adaptable to abiotic stresses and is tolerant to drought and salt stresses. Results Here, we provide a draft de novo genome of pistachio as well as large-scale genome resequencing. Comparative genomic analyses reveal stress adaptation of pistachio is likely attributable to the expanded cytochrome P450 and chitinase gene families. Particularly, a comparative transcriptomic analysis shows that the jasmonic acid (JA) biosynthetic pathway plays an important role in salt tolerance in pistachio. Moreover, we resequence 93 cultivars and 14 wild P. vera genomes and 35 closely related wild Pistacia genomes, to provide insights into population structure, genetic diversity, and domestication. We find that frequent genetic admixture occurred among the different wild Pistacia species. Comparative population genomic analyses reveal that pistachio was domesticated about 8000 years ago and suggest that key genes for domestication related to tree and seed size experienced artificial selection. Conclusions Our study provides insight into genetic underpinning of local adaptation and domestication of pistachio. The Pistacia genome sequences should facilitate future studies to understand the genetic basis of agronomically and environmentally related traits of desert crops. Electronic supplementary material The online version of this article (10.1186/s13059-019-1686-3) contains supplementary material, which is available to authorized users.

Global vegetated coastal habitats (VCHs) represent a large sink for organic carbon (OC) stored within their soils. The regional patterns and causes of spatial variation, however, remain uncertain. The sparsity and regional bias of studies on soil OC stocks from Chinese VCHs have limited the reliable estimation of their capacity as regional and global OC sinks. Here, we use field and published data from 262 sampled