2021
DOI: 10.3390/cancers13040827
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Abstract: Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant and the therapeutic options available usually have little impact on survival. Great hope is placed on new therapeutic targets, including long noncoding RNAs (lncRNAs), and on the development of new drugs, based on e.g., broccoli-derived sulforaphane, which meanwhile has shown promise in pilot studies in patients. We examined whether sulforaphane interferes with lncRNA signaling and analyzed five PDAC and two nonmalignant cell lines, patient tissues… Show more

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Cited by 15 publications
(14 citation statements)
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“…↓ BRAF-activated long noncoding RNA (BANCR) luteolin thyroid carcinoma [182] long non-coding RNA epigallocatechin-3-gallate lung cancer [183] ↓ lnc RNA LINC00511 gastric cancer [184] ↓ lncRNAs H19 sulforaphane pancreatic ductal adenocarcinoma [185] ↓ lncRNA LUCAT1 vitamin D oral squamous cell carcinoma [186] ↓ lncRNA CCAT2 ovarian cancer [187] ↑ lncRNA MEG3 colorectal cancer [188]…”
Section: Mechanisms Bioactive Component Disorders Referencesmentioning
confidence: 99%
“…↓ BRAF-activated long noncoding RNA (BANCR) luteolin thyroid carcinoma [182] long non-coding RNA epigallocatechin-3-gallate lung cancer [183] ↓ lnc RNA LINC00511 gastric cancer [184] ↓ lncRNAs H19 sulforaphane pancreatic ductal adenocarcinoma [185] ↓ lncRNA LUCAT1 vitamin D oral squamous cell carcinoma [186] ↓ lncRNA CCAT2 ovarian cancer [187] ↑ lncRNA MEG3 colorectal cancer [188]…”
Section: Mechanisms Bioactive Component Disorders Referencesmentioning
confidence: 99%
“…Recently, the lncRNA H19 (H19) has been identified as a cancer promotor in different cancer types (6)(7)(8)(9). H19 is highly expressed in PDAC, and it promotes proliferation, migration, and metastasis (6,(10)(11)(12). We identified the innate anti-viral immunity gene APOBEC3G as a major H19 downstream gene (12,13) and demonstrated that the downregulation of H19 or APOBEC3G by siRNA or the bioactive agent sulforaphane prevented H19-mediated PDAC progression features as demonstrated by assays for colony formation, migration, invasion, Smad2 phosphorylation and tumor xenograft growth (12).…”
Section: Introductionmentioning
confidence: 99%
“…Finally, we verified our concept in vivo by the use of tumor xenotransplantation to fertilized chicken eggs. This avian model is an excellent alternative to experiments performed on mammals, such as mice [ 63 ], and has been evaluated in several of our recent studies [ 64 , 65 ]. One major advantage of the chicken egg model is its natural immunodeficiency because immunity occurs only after hatching [ 66 ].…”
Section: Discussionmentioning
confidence: 99%