Sulfobetaine‐functionalized electrospun poly(ethylene‐co‐vinyl alcohol) membranes for blood filtration

Abstract

Functionalization imparting zwitterionic sulfobetaines has been proven as the most versatile method for improving the hemocompatibility of polymers. In this study, we aimed to enhance the hemocompatibility of electrospun poly(ethylene‐co‐vinyl alcohol) (EVAL) by photografting with a betaine N‐(3‐sulfopropyl)‐N‐methacroyloxyethyl‐N,N‐dimethyl ammonium betaine (SMDB). SMDB was UV‐photografted to electrospun EVAL fibroporous membranes to obtain EVAL‐g‐PSMDB poly[N‐(3‐sulfopropyl)‐N‐methacroyloxyethyl‐N,N‐ dimethylammonium betaine] grafted on EVAL with different extents of grafting. The functionalization was confirmed by analysis of the attenuated total reflectance–Fourier transform infrared spectra. The effects of functionalization on the morphology, wettability, mechanical properties, and hemocompatibility of the electrospun EVAL membranes were also studied by scanning electron microscopy, water contact angle measurement, universal testing machine measurement, and in vitro hemocompatibility evaluation, respectively. The findings highlight that SMDB functionalization significantly reduced protein adsorption, hemolysis, and platelet adhesion. Blood cell consumption studies projected that the SMDB‐functionalized EVAL was able to capture leukocytes from blood, and hence, this system has the potential to be used as a filter medium for the selective removal of leukocytes from blood. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47057.

Aminolysis-Based Zwitterionic Immobilization on Polyethersulfone Membranes for Enhanced Hemocompatibility: Experimental, Computational, and Ex Vivo Investigations

“…Several SB-enhanced materials have been suggested in the literature for dialysis applications. Sulfobetaine was used as a modifier of poly(ethylene-co-vinyl alcohol) (EVOL) [ 20 ]. PSF modification using SB structures has been reported by Gu et al, which resulted in lower platelet attachment [ 21 ].…”

Investigation of the potency of leukodepletion filter membranes immobilized with bovine serum albumin via polydopamine spacer

“…To summarize a few of the most efficacious routes of membrane modifications to bring in all or many of the above-mentioned aspects include introduction of polyethylene glycol (PEG) brushes, grafting of other monomers, incorporation of suitable additives like zwitterions, attaching different functionalities by coupling reactions, attaching biomolecules like proteins, anticoagulants including heparin, etc. [5][6][7][8]. Amidst these, decoration of membranes with coating or covalent attachment of proteins is not only a promising approach, but a bioinspired one over other synthetic materials.…”