Sulfated modification of the polysaccharide from Sphallerocarpus gracilis and its antioxidant activities

Xu, Yunfei; Song, Shaoxian; Wei, Yijun; Wang, Fengxia; Zhao, Min; Guo, Jie; Zhang, Ji

doi:10.1016/j.ijbiomac.2016.02.037

Cited by 63 publications

(34 citation statements)

References 39 publications

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“…The sharp absorption peak at 1259 cm −1 (S–O asymmetry stretching vibration) and 813 cm −1 (C–O–S symmetry stretching vibration) were assigned to the sulfated group in S-CP 1–4 33. The spectral information was similar to the FT-IR spectra of sulfated Ganoderma atrum polysaccharides and Sphallerocarpus polysaccharides183435.…”

Section: Resultsmentioning

confidence: 55%

Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Wang

Xie

Yang

et al. 2017

Sci Rep

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Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of Cyclocarya paliurus polysaccharides (CP). A sulfated CP, S-CP1–4 was obtained using chlorosulfonic acid-pyridine method. The chemical components and FT-IR spectrum confirmed that sulfated group was synthesized to the polysaccharide chains successfully. S-CP1–4 was found to inhibit nitric oxide production, phagocytic activity and the release of interleukin (IL)-6 and IL-1β in lipopolysaccharide-treated macrophage cells, RAW 264.7. S-CP1–4 significantly decreased the secretion of IL-6 and TNF-α and the thymus and spleen indexes, and increased the production of IL-10 in lipopolysaccharide-treated mice. S-CP1–4 could better protect the liver by inhibiting the activities of alanine aminotransferase and aspartate aminotransferase, and malondialdehyde level while increasing the superoxide dismutase activity and total anti-oxidative capacity. These results suggested that S-CP1–4 may be an effective anti-inflammatory agent, and sulfated modification may be a reliable method for the development of food supplements.

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Section: Resultsmentioning

confidence: 55%

Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Wang

Xie

Yang

et al. 2017

Sci Rep

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“…Balavigneswaran et al [20] extracted crude polysaccharide from I. galbana (20.0 mg/mL) and reported hydroxyl radical scavenging effects of approximately 60%. Xu et al [39] reported a polysaccharide extracted from Sphallerocarpus gracilis with a hydroxyl radical scavenging effect of approximately 70% at 5.0 mg/mL. A chemical modification of polysaccharide is the form of a sulfated derivative produced a similar hydroxyl radical scavenging effect (80%) as the crude polysaccharide used in this study.…”

Section: Resultsmentioning

confidence: 68%

“…Above 5.0 mg/mL, the increased concentration had no effect on superoxide radical. The extracted polysaccharide and a chemically modified sulfated derivative from Sphallerocarpus gracilis [39] showed superoxide radical scavenging effects of approximately 50% and 70%, respectively. Balavigneswaran et al [20] extracted crude polysaccharide from Isochrysis galbana (5.0 mg/mL) and reported that the corresponding superoxide radical scavenging effect was about 42%.…”

Section: Resultsmentioning

confidence: 99%

Extraction Optimization, Purification, Antioxidant Activity, and Preliminary Structural Characterization of Crude Polysaccharide from an Arctic Chlorella sp.

Song

et al. 2018

Polymers

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Abstract:The arctic strain of Chlorella sp. (Chlorella-Arc) exists in the coldest and driest arctic ecosystems, and it is a new resource of active polysaccharides. The extraction of crude polysaccharide from Chlorella-Arc was optimized using the response surface methodology. A crude polysaccharide yield of approximately 9.62 ± 0.11% dry weight was obtained under these optimized conditions. Three fractions (P-I, P-II, and P-III) were present after purification by 2-diethylaminoethanol Sepharose Fast Flow and Sephadex G-100 chromatography. The P-IIa fraction demonstrated significant antioxidant activities. Moreover, P-IIa was an α-and β-type heteropolysaccharide with a pyran group and contained variable amounts of rhamnose, arabinose, glucose, and galactose based on fourier-transform infrared spectroscopy, high-performance liquid chromatography, and 1 H and 13 C nuclear magnetic resonance imaging. Production of high amounts of polysaccharide may allow further exploration of the microalgae Chlorella-Arc as a natural antioxidant.

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“…The physicochemical properties of S-EPS11 were determined to assess the efficiency of the sulfation modification ( Notably, the FTIR analysis indicated that S-EPS11 had the presence of C-O-S (at 815 cm -1 ) and S=O (at 1129 cm -1 ) stretching vibrations ( fig. 2B) [4,12,28]; meanwhile, natural EPS did not. This demonstrated that we sucessfuly synthesize sulfated EPS from O. sinensis fungus.…”

Section: Science and Technology Development Journal: Natural Sciencesmentioning

confidence: 94%

Preparation of a sulfated exopolysaccharide (S-EPS) from Ophiocordyceps sinensis fungus and its antioxidant effects

Tran¹,

Nguyen²,

Nguyen³

et al. 2019

Sci. Tech. Dev. J. - Nat. Sci.

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Sulfated exopolysaccharides have been well-known to enhance biological activities. Exopolysaccharide (EPS) produced by Ophiocordyceps sinensis fungus is a source of natural compounds. The aim of our study is to improve the EPS biological activities by its sulfated modification using the chlorosulfonic acid (CSA)-pyridine (Pyr) method. The appropriate conditions of the sulfation reaction were explored, including CSA/Pyr ratio (v/v) of 1:3 and 6h. The degree of substitution (DS) of S-EPS11 was the highest (DS = 1.59). The total contents of polysaccharides and SO42- of S-EPS11 were 52.25% and 47.15%, respectively. Besides, the FT-IR spectra analysis indicated the presence of CO-S (peak of 815 cm-1) and S=O (peak of 1129 cm-1) stretching vibrations, while the natural EPS did not appear. Importantly, OH• and ABTS• radical scavenging potential of S-EPS11 significantly increased compared with those of the natural EPS. Together, we successfully generated sulfated EPS extracted from O. sinensis fungus which enhanced antioxidant activities of natural EPS.

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Sulfated modification of the polysaccharide from Sphallerocarpus gracilis and its antioxidant activities

Cited by 63 publications

References 39 publications

Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Extraction Optimization, Purification, Antioxidant Activity, and Preliminary Structural Characterization of Crude Polysaccharide from an Arctic Chlorella sp.

Preparation of a sulfated exopolysaccharide (S-EPS) from Ophiocordyceps sinensis fungus and its antioxidant effects

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