Sulfated bromophenols from Osmundaria obtusiloba (C. Agardh) R. E. Norris (Rhodophyta, Ceramiales)

Carvalho, Luciana Retz de; Guimarães, Sílvia; Roque, Nı́dia Franca

doi:10.1590/s0100-84042006000300012

Cited by 10 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many articles have reported antimicrobial activity of halogenated sesquiterpenes and acetogenins derived from Laurencia species, especially for (−)-elatol, obtusol, (+)-obtusane, cartilagineol, and triquinane derivatives [ 36 , 37 ]. Studies performed with Osmundaria species are scarce, but some compounds so far described have potential antimicrobial activity, particularly the halogenated phenol derivatives, such as lanosol and sulfated oligobromophenols [ 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Infective Potential of Marine Invertebrates and Seaweeds from the Brazilian Coast

et al. 2013

View full text Add to dashboard Cite

This manuscript describes the evaluation of anti-infective potential in vitro of organic extracts from nine sponges, one ascidian, two octocorals, one bryozoan, and 27 seaweed species collected along the Brazilian coast. Antimicrobial activity was tested against Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922) and Candida albicans (ATCC 10231) by the disk diffusion method. Antiprotozoal activity was evaluated against Leishmania braziliensis (MHOM/BR/96/LSC96-H3) promastigotes and Trypanosoma cruzi (MHOM/BR/00/Y) epimastigotes by MTT assay. Activity against intracellular amastigotes of T. cruzi and L. brasiliensis in murine macrophages was also evaluated. Antiviral activity was tested against Herpes Simplex Virus type 1 (HSV-1, KOS strain) by the plaque number reduction assay (IC50). Cytotoxicity on VERO cells was evaluated by the MTT assay (CC50). The results were expressed as SI = CC50/IC50. The most promising antimicrobial results were obtained against S. aureus and C. albicans with Dragmacidon reticulatum. Among the seaweeds, only Osmundaria obtusiloba showed moderate activity against P. aeruginosa. Concerning antiprotozoal activity, Bugula neritina, Carijoa riseii, Dragmaxia anomala and Haliclona (Halichoclona) sp. showed the most interesting results, mainly against extracellular promastigote forms of L. braziliensis (66, 35.9, 97.2, and 43.6% inhibition, respectively). Moreover, six species of seaweeds Anadyomene saldanhae, Caulerpa cupressoides, Canistrocarpus cervicornis, Dictyota sp., Ochtodes secundiramea, and Padina sp. showed promising results against L. braziliensis (87.9, 51.7, 85.9, 93.3, 99.7, and 80.9% inhibition, respectively), and only Dictyota sp. was effective against T. cruzi (60.4% inhibition). Finally, the antiherpes activity was also evaluated, with Haliclona (Halichoclona) sp. and Petromica citrina showing the best results (SI = 11.9 and SI > 5, respectively). All the active extracts deserve special attention in further studies to chemically characterize the bioactive compounds, and to perform more refined biological assays.

show abstract

Section: Resultsmentioning

confidence: 99%

Anti-Infective Potential of Marine Invertebrates and Seaweeds from the Brazilian Coast

et al. 2013

View full text Add to dashboard Cite

show abstract

“…De Alencar et al (2016) showed that the 70% EtOH was the most effective solvent for extracting phenolic compounds from red seaweeds when compared to hexane, and O. obtusiloba EtOH extract presented high antioxidant activity. Seven substances were identified in Brazilian O. obtusiloba : three sulfated bromophenols, two bromophenols, one sterol and one glyceride (Carvalho et al, 2006). Given that O. obtusiloba ethanolic extract is rich in bromophenols, it is possible that these compounds may be responsible for the inhibitory effects of CHIKV replication.…”

Section: Discussionmentioning

confidence: 99%

Inhibition by Marine Algae of Chikungunya Virus Isolated From Patients in a Recent Disease Outbreak in Rio de Janeiro

et al. 2019

View full text Add to dashboard Cite

Chikungunya virus (CHIKV) infection is one of the most challenging re-emergent diseases caused by a virus, and with no specific antiviral treatment it has now become a major public health concern. In this investigation, 25 blood samples were collected from patients with characteristic CHIKV symptoms and submitted to a virus isolation protocol, which detected 3 CHIKV isolates. These samples were evaluated by sequencing for the characterization of the strains and any homology to viruses circulating in Brazil during a recent outbreak. These viruses were used for the development of antiviral assays. Subsequently, the inhibitory effects of seaweed extracts on CHIKV replication were studied. The marine species of algae tested were Bryothamnion triquetrum, Caulerpa racemosa, Laurencia dendroidea, Osmundaria obtusiloba, Ulva fasciata, and Kappaphycus alvarezii, all of which are found in different countries including Brazil. The results revealed high levels of CHIKV inhibition, including extracts of O. obtusiloba with inhibition values of 1.25 μg/mL and a selectivity index of 420. Viral inhibition was dependent on the time of addition of extract of O. obtusiloba to the infected cells, with the optimal inhibition occurring up to 16 h after infection. Neuron evaluations with O. obtusiloba were performed and demonstrated low toxicity, and in infected neurons we observed high inhibitory activity in a dose-dependent manner. These results indicate that the algal extracts may be promising novel candidates for the development of therapeutic agents against CHIKV infections.

show abstract

“…The extract was evaporated under reduced pressure, yielding crude extract (15 to 20 mg), of which 2 to 5 mg was used in tests against the ZIKV. The ethanolic extract was chosen due to the efficiency of ethanol in extracting the phenolic compounds from O. obtusiloba (Carvalho et al, 2006) and also the low toxicity in vivo of this extract (de Souza Barros et al, 2018).…”

Section: Seaweed Materials and Extractionmentioning

confidence: 99%

Antiviral effect of the seaweed Osmundaria obtusiloba against the Zika virus

Cirne-Santos¹,

Barros²,

Nogueira³

et al. 2018

J. Med. Plants Res.

View full text Add to dashboard Cite

Zika virus (ZIKV), a mosquito-borne member of the family Flaviviridae, is a human pathogen of global significance. Recently, ZIKV, has become a public health problem with increases in numbers of cases and a strong association between ZIKV outbreaks and the spread of cases of Guillain-Barré Syndrome and microcephaly. In this study, the extracts of the seaweed Osmundaria obtusiloba (O. obtusiloba) (native to the Brazilian coast) against ZIKV using Vero cells was evaluated. The seaweed extract tested inhibited ZIKV replication in a dose-dependent manner at low concentrations with EC 50 values of 1.82 μg/mL and a selective index (SI) of 288. Other results showed that this extract had significant virucidal effects. In addition, when the extract and Ribavirin were used concomitantly there was a significant synergistic effect. Our promising results suggest that extracts of O. obtusiloba are excellent candidates for further studies, and that marine algae are potentially important sources for the development of novel anti-ZIKV agents.

show abstract

Sulfated bromophenols from Osmundaria obtusiloba (C. Agardh) R. E. Norris (Rhodophyta, Ceramiales)

Cited by 10 publications

References 22 publications

Anti-Infective Potential of Marine Invertebrates and Seaweeds from the Brazilian Coast

Anti-Infective Potential of Marine Invertebrates and Seaweeds from the Brazilian Coast

Inhibition by Marine Algae of Chikungunya Virus Isolated From Patients in a Recent Disease Outbreak in Rio de Janeiro

Antiviral effect of the seaweed Osmundaria obtusiloba against the Zika virus

Contact Info

Product

Resources

About