2019
DOI: 10.3389/fmicb.2019.02426
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Inhibition by Marine Algae of Chikungunya Virus Isolated From Patients in a Recent Disease Outbreak in Rio de Janeiro

Abstract: Chikungunya virus (CHIKV) infection is one of the most challenging re-emergent diseases caused by a virus, and with no specific antiviral treatment it has now become a major public health concern. In this investigation, 25 blood samples were collected from patients with characteristic CHIKV symptoms and submitted to a virus isolation protocol, which detected 3 CHIKV isolates. These samples were evaluated by sequencing for the characterization of the strains and any homology to viruses circulating in Brazil dur… Show more

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Cited by 17 publications
(14 citation statements)
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“…The sulfated polysaccharides of seaweeds have been shown to exhibit antiviral activity against a broad spectrum of viruses. It has been reported to inhibit antiviral activity against Herpes Simplex virus (HSV) ( Gomaa and Elshoubaky, 2016 ), Human immunodeficiency virus type-1 (HIV-1) ( Besednova et al, 2019 ), chikungunya virus ( Cirne-Santos et al, 2019 ), and many other enveloped and non-enveloped viruses. Also, the antiviral activity of SPs against the currently on-going pandemic coronavirus disease 2019 (COVID-19) is reported ( Chen et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%
“…The sulfated polysaccharides of seaweeds have been shown to exhibit antiviral activity against a broad spectrum of viruses. It has been reported to inhibit antiviral activity against Herpes Simplex virus (HSV) ( Gomaa and Elshoubaky, 2016 ), Human immunodeficiency virus type-1 (HIV-1) ( Besednova et al, 2019 ), chikungunya virus ( Cirne-Santos et al, 2019 ), and many other enveloped and non-enveloped viruses. Also, the antiviral activity of SPs against the currently on-going pandemic coronavirus disease 2019 (COVID-19) is reported ( Chen et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%
“…Recent in vitro studies revealed that seaweed extracts have anti-herpes simplex virus (HSV-1, NSV-2) [6,7], anti-human immunodeficiency virus (HIV-1) [7,8], antichikungunya virus [9], anti-enterovirus (ECHO-1) [7] properties and inactivated measles virus [10] to name a few. Extensive reviews suggest that seaweed extracts can block virus-host attachment, virus entry to the cell or inhibit the replication of several types of enveloped viruses in vitro [11][12][13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…A series of thioguanine-coumarins derivatives were studied, and the methoxylated coumarins [54] (21, 22 and 23) exhibited the best activities against CHIKV compared to the benzouracil coumarins (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). EC 50 values were below 13.9 µM with a significant selectivity window covering SI values between 9.37 and 21.7, whereas the molecular lipophilicity of 20, 21, 22 and 23 were between 2.97 and 3.77.…”
Section: Nitrogen Heterocycle-coumarin Hybrid Compoundsmentioning
confidence: 99%
“…CHIKV has a single-strand, positive-polarity RNA genome, whose size varies between 9.7 and 12 kb [ 13 ]. The viral particles, which are often spherical, have a diameter of 70 nm and an isometric nucleocapsid of 40 nm [ 14 ]. The proteins are encoded by two open reading frames (ORFs) in which the first two-thirds of the genome from the 5′ end is responsible for expression of the non-structural proteins (NSPs) named nsP1, nsP2, nsP3, and nsP4; whereas the last one-third located at the 3′ end codifies a subgenomic RNA that originates from three structural proteins and two peptides: capsid (C), enveloped glycoprotein 1 (E1), glycoprotein enveloped 2 (E2), E3, and 6K [ 1 , 15 , 16 ].…”
Section: Chikv Infectionmentioning
confidence: 99%
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