Sulfanilamide and Allied Compounds

Combes, Frank C.

doi:10.1001/archderm.1941.01500020091009

Cited by 13 publications

(2 citation statements)

References 9 publications

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“…HA is a natural polysaccharide comprised repeated d -glucuronic acid and N-acetyl glucosamine disaccharide units connected by −1,4 and −1,3 glycosidic linkages. Because of its unique bioactivity, biocompatibility, and nontoxicity, HA has been employed successfully in pharmaceuticals, cosmetics, and functional foods . An earlier study indicated a promising application of chlorhexidine gluconate at a low concentration (0.1%) incorporated into chitosan gel for candidiasis in the oral cavity. , …”

Section: Resultsmentioning

confidence: 99%

“…Because of its unique bioactivity, biocompatibility, and nontoxicity, HA has been employed successfully in pharmaceuticals, cosmetics, and functional foods. 32 An earlier study indicated a promising application of chlorhexidine gluconate at a low concentration (0.1%) incorporated into chitosan gel for candidiasis in the oral cavity. 31,33 3.1.1.…”

Section: Formulation Development and Characterizationsmentioning

confidence: 99%

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Development, Evaluation, and Molecular Dynamics Study of Ampicillin-Loaded Chitosan–Hyaluronic Acid Films as a Drug Delivery System

Arısoy,

Bux,

Herwig

et al. 2024

ACS Omega

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Periodontitis is an inflammatory periodontal disease defined by the progressive loss of tissues surrounding the tooth. Ampicillin is an antibiotic for managing and treating specific bacterial infections, including periodontitis. Periodontal pockets occur due to periodontal disease progression and act as a natural reservoir that is easily reachable for the insertion of a delivery system, and the amount of drug to be released has a major role in the efficiency of treatment of the disease. Polyelectrolyte complexes (PECs), particularly those based on chitosan and hyaluronic acid combinations, offer a promising avenue to overcome the challenges associated with drug delivery. These complexes are both biodegradable and biocompatible, making them an optimal choice for enabling targeted drug delivery. This study centers on developing and assessing the structure and dynamic attributes of a drug−PEC system encompassing ampicillin and chitosan−hyaluronic acid components, which represents a targeted drug delivery system to better alleviate the periodontitis. To achieve this goal, we conducted experiments including weight and drug content uniformity, swelling ındex, drug release %, FT-IR and SEM analyses, and atomistic molecular dynamics simulations on the drug PECs loaded with ampicillin with varying amounts of hyaluronic acid. All simulations and the experimental analysis suggested that increased HA amount resulted in an increase in drug release % and swelling index. The simulation outcomes provide insights into the nature of the drug and PEC interactions alongside transport properties such as drug diffusion coefficients. These coefficients offer valuable insights into the molecular behavior of ampicillin−PEC drug delivery systems, particularly in the context of their application in periodontitis treatment.

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Section: Resultsmentioning

confidence: 99%