Sulfadiazine-Potentiometric Sensors for Flow and Batch Determinations of Sulfadiazine in Drugs and Biological Fluids

Kamel, Ayman H.; Almeida, S.A.A.; Sales, M. Goreti F.; Moreira, Felismina T.C.

doi:10.2116/analsci.25.365

Cited by 40 publications

(40 citation statements)

References 44 publications

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“…Each resulting homogenous mixture was cast over graphitebased conductive supports, deposited on the edge of a Perspex cylinder tube and to which an electrical wire had been connected, as described elsewhere [14]. ISEs made with micropipette tips confer the best membrane composition when applied at the end of the tip.…”

Section: Preparation and Construction Of The Sdm Sensormentioning

confidence: 99%

New and low cost plastic membrane electrode with low detection limits for sulfadimethoxine determination in aquaculture waters

Almeida

Montenegro

Sales

2013

Journal of Electroanalytical Chemistry

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A B S T R A C TSulfadimethoxine (SDM) is one of the drugs, often used in the aquaculture sector to prevent the spread of disease in freshwater fish aquaculture. Its spread through the soil and surface water can contribute to an increase in bacterial resistance. It is therefore important to control this product in the environment. This work proposes a simple and low-cost potentiometric device to monitor the levels of SDM in aquaculture waters, thus avoiding its unnecessary release throughout the environment. The device combines a micro-pipette tip with a PVC membrane selective to SDM, prepared from an appropriate cocktail, and an inner reference solution. The membrane includes 1% of a porphyrin derivative acting as ionophore and a small amount of a lipophilic cationic additive (corresponding to 0.2% in molar ratio). The composition of the inner solution was optimized with regard to the kind and/or concentration of primary ion, chelating agent and/or a specific interfering charged species, in different concentration ranges. Electrodes con-structed with inner reference solutions of 1 x 10 -8 mol/L SDM and 1 x 10 -4 mol/L chromate ion showed the best analytical features. Near-Nernstian response was obtained with slopes of -54.1 mV/decade, an extraordinary detection limit of 7.5 ng/mL (2.4 x 10 -8 mol/L) when compared with other electrodes of the same type. The reproducibility, stability and response time are good and even better than those obtained by liquid contact ISEs.Recovery values of 98.9% were obtained from the analysis of aquaculture water samples.

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Section: Preparation and Construction Of The Sdm Sensormentioning

confidence: 99%

New and low cost plastic membrane electrode with low detection limits for sulfadimethoxine determination in aquaculture waters

Almeida

Montenegro

Sales

2013

Journal of Electroanalytical Chemistry

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“…Graphite-based electrodes were constructed with a conventional shape (similar to pH electrodes) or a tubular configuration for batch and flow evaluations, respectively [12]. The electrode body was made from Perspex® and had a conductive solid contact prepared with graphite/epoxy resin exposed on one side, and polished prior to membrane coating.…”

Section: Construction Of the Electrode Bodymentioning

confidence: 99%

“…Chemical sensors relying on charged and neutral carriers are also effective and have been proposed [12,13]. Both sensors offer suitable analytical features for conducting continuous analysis of the administered drug, ion exchangers being much less expensive sensory materials than neutral/charged carriers.…”

Section: Introductionmentioning

confidence: 99%

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Rapid automated method for on-site determination of sulfadiazine in fish farming: a stainless steel veterinary syringe coated with a selective membrane of PVC serving as a potentiometric detector in a flow-injection-analysis system

et al. 2011

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Sulfadiazine is an antibiotic of the sulfonamide group and is used as a veterinary drug in fish farming. Monitoring it in the tanks is fundamental to control the applied doses and avoid environmental dissemination. Pursuing this goal, we included a novel potentiometric design in a flow-injection assembly. The electrode body was a stainless steel needle veterinary syringe of 0.8-mm inner diameter. A selective membrane of PVC acted as a sensory surface. Its composition, the length of the electrode, and other flow variables were optimized. The best performance was obtained for sensors of 1.5-cm length and a membrane composition of 33% PVC, 66% onitrophenyloctyl ether, 1% ion exchanger, and a small amount of a cationic additive. It exhibited Nernstian slopes of 61.0 mV decade -1 down to 1.0×10 -5 mol L -1 , with a limit of detection of 3.1×10 -6 mol L -1 in flowing media. All necessary pH/ionic strength adjustments were performed online by merging the sample plug with a buffer carrier of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, pH 4.9. The sensor exhibited the advantages of a fast response time (less than 15 s), long operational lifetime (60 days), and good selectivity for chloride, nitrite, acetate, tartrate, citrate, and ascorbate. The flow setup was successfully applied to the analysis of aquaculture waters. The analytical results were validated against those obtained with liquid chromatography-tandem mass spectrometry procedures. The sampling rate was about 84 samples per hour and recoveries ranged from 95.9 to 106.9%.

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“…Metalophthalocyanines and metaloporphyrins have been widely employed in sensor construction with different transducer systems, such as optical, [8][9][10][11][12][13] chemoresistive, [14][15][16][17][18] i m p e d i m e t r i c , 1 9 p i e z o e l e c t r i c 2 0 , 2 1 a n d m a i n l y electrochemical, [22][23][24][25][26][27][28][29][30] since they present high electrocatalytic activities for many redox reactions. In addition, enzymeless sensors 31,32 using these macrocycles [33][34][35][36][37][38] as biomimetic active sites of redox enzymes, as peroxidase, 34,37 dopamine monooxigenase 38 and P450 35,36 have been described, offering a real and an alternative tool to official analytical methods.…”

Section: Introductionmentioning

confidence: 99%

Application of a biomimetic sensor based on iron phthalocyanine chloride: 4-methylbenzylidene-camphor detection

Boni¹,

Sotomayor²,

Lanza³

et al. 2010

J. Braz. Chem. Soc.

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A construção e a aplicação de um sensor biomimético para a determinação de 4-metilbenzilideno cânfora (4-MBC), um protetor de radiação ultravioleta (UV), são descritas. O sensor foi preparado pela modificação de um eletrodo de pasta de carbono com um complexo de cloreto de ferro(III) com ftalocianina, FePcCl. As medidas amperométricas conduzidas com o sensor, sob um potencial aplicado de 0,0 V vs. Ag|AgCl em uma mistura de tetraidrofurano e 0,1 mol L -1 H 2 SO 4 (30:70 em volume), mostraram uma resposta linear no intervalo de 1,8×10 -4 to 9,0×10 -4 mol L -1 . Uma investigação detalhada da seletividade da resposta frente a outros nove filtros UV também foi realizada. Um mecanismo de resposta do sensor foi proposto e os resultados para a quantificação de 4-MBC em protetores solares comerciais e em águas de piscinas e de rios são apresentados.The construction and application of a biomimetic sensor for determination of 4-methylbenzylidene camphor (4-MBC), an ultraviolet (UV) radiation protector, are described. The sensor was prepared by modifying a carbon paste electrode with iron(III) phthalocyanine chloride (FePcCl). Amperometric measurements carried out with the sensor under an applied potential of 0.0 V vs. Ag|AgCl in a mixture of tetrahydrofuran and 0.1 mol L -1 H 2 SO 4 solution (30:70 volume ratio) showed a linear response range from 1.8×10 -4 to 9.0×10 -4 mol L -1 . A detailed selectivity investigation for other nine UV filters was also performed. A sensor response mechanism was proposed and the results for 4-MBC quantification in commercial sunscreens and in water from swimming pools and rivers are presented.Keywords: iron phthalocyanine, amperometric sensor, methylbenzylidene camphor IntroductionChemical ultraviolet (UV) filters have been introduced in 1889, when an acidified quinine sulfate solution was used to block UV radiation, 1 and thereafter sunscreen has become an everyday cosmetic with continuously increasing use.The positive effect exerted by UV filters is to block the UV light radiation damage from sunlight, sunlamps and in tanning parlours; moreover, they have color protective abilities and therefore may prevent premature fading of hair color and damage to hair cuticle. On the other hand, it has been recently reported that commonly used chemical UV filters may cause endocrine disrupting effects in both aquatic and terrestrial animals, as well as in human skin cells. [1][2][3][4] In addition, five of the most commonly UV filters used in cosmetic formulations, i.e., oxybenzone, octyl methoxycinnamate (OMC), homosalate, p-aminobenzoic acid (PABA), octyldimethyl-PABA (ODP), and 4-methylbenzylidene camphor (4-MBC), exhibited oestrogenic effects in MCF-7 (Michigan Application of a Biomimetic Sensor Based on Iron Phthalocyanine Chloride J. Braz. Chem. Soc. 1378 Cancer Foundation-7) breast cancer cells. Furthermore, oxybenzone, 4-MBC and OMC were confirmed to be oestrogenic by classical in vivo uterotrophic assays with rats dosed in the feed. For the most potent oestrogenic UV filter 4-MBC, the eff...

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Sulfadiazine-Potentiometric Sensors for Flow and Batch Determinations of Sulfadiazine in Drugs and Biological Fluids

Cited by 40 publications

References 44 publications

New and low cost plastic membrane electrode with low detection limits for sulfadimethoxine determination in aquaculture waters

New and low cost plastic membrane electrode with low detection limits for sulfadimethoxine determination in aquaculture waters

Rapid automated method for on-site determination of sulfadiazine in fish farming: a stainless steel veterinary syringe coated with a selective membrane of PVC serving as a potentiometric detector in a flow-injection-analysis system

Application of a biomimetic sensor based on iron phthalocyanine chloride: 4-methylbenzylidene-camphor detection

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