Suicide attempts in children and adolescents: The place of clock genes and early rhythm dysfunction

Olliac, Bertrand; Ouss, Lisa; Charrier, Annaëlle

doi:10.1016/j.jphysparis.2017.11.001

Cited by 5 publications

(3 citation statements)

References 97 publications

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“…The aetiology of TMD disorders is multifactorial with environmental, biological and psychological factors acting synergistically in the development of TMD. Modern lifestyles result in a more stressful environment for children and adolescents, with increased stimuli now beginning in early childhood through the use of applications, tablets and social media. Previous studies demonstrated that stress and anxiety are strongly associated with TMD in children …”

Section: Introductionmentioning

confidence: 99%

The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents

Brancher

Spada

Meger

et al. 2019

J of Oral Rehabilitation

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Summary Background Temporomandibular disorder (TMD) is a multifactorial condition involving environmental, psychological and genetic factors. Objective The aim of this case‐control study was to evaluate the influence of genetic polymorphisms in 5HTT and COMT on TMD and anxiety in adolescents. Methods TMD was diagnosed and classified according to the RDC/TMD criteria. For case group, the following TMD categories were used: myofascial pain, disc displacement, arthralgia and painful TMD (myofascial and arthralgia). Anxiety levels were assessed according to the State‐Trait Anxiety Inventory. Genomic DNA was extracted, and genetic polymorphisms were genotyped by TaqMan chemistry and endpoint analysis. Logistic multivariate regression was used to analyse the associations between TMD types and genotypes, anxiety level and genotypes, using an adjusted odds ratio (ORa; CI 95%) that considered the gender. Results In 5HTT, the rs1042173 was associated with painful TMD (arthralgia and myofascial pain) (ORc = 1.97; CI 95%: 1.02‐3.77; P = 0.04). Polymorphisms in COMT rs4818 were significantly associated with myofascial pain (ORc = 2.15; CI 95%: 1.08‐4.29; P = 0.02) and were borderline for painful TMD (ORc = 1.85; CI 95%: 0.97‐3.51; P = 0.06) and disc displacement (ORc = 2.42; CI 95%: 1.00‐5.87; P = 0.05). The rs6269 was borderline for myofascial pain (ORc = 1.82; CI 95%: 0.92‐3.59; P = 0.08) and disc displacement (ORc = 2.38; CI 95% 0.95‐5.97; P = 0.06) and also was associated with anxiety (ORa = 2.34; CI 95% 1.04‐5.25; P = 0.03). Conclusion Polymorphisms in 5HTT and COMT are associated with TMD in adolescents. Moreover, polymorphism in COMT is associated with anxiety in adolescents.

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Section: Introductionmentioning

confidence: 99%

The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents

Brancher

Spada

Meger

et al. 2019

J of Oral Rehabilitation

View full text Add to dashboard Cite

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“…Likewise, early trauma and stressful life events can alter the expression of clock genes and lead to suicide attempts. In addition, changes in clock genes may lead to dyssynchrony and abnormality of circadian rhythms, thus damaging both the synchronization of external and internal rhythms and the individuals’ ability to adapt to internal and external environments [ 22 ]. This leads to the development of mental health issues and increases the risk of suicide attempts [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, changes in clock genes may lead to dyssynchrony and abnormality of circadian rhythms, thus damaging both the synchronization of external and internal rhythms and the individuals’ ability to adapt to internal and external environments [ 22 ]. This leads to the development of mental health issues and increases the risk of suicide attempts [ 22 ]. Another study demonstrated that circadian clock genes can be considered candidates for a molecular link—that is, the association between eveningness and adverse affective functions [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Role of polygenic risk scores in the association between chronotype and health risk behaviors

Zhang,

Li,

Xie

et al. 2023

BMC Psychiatry

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Background This study explores the association between chronotypes and adolescent health risk behaviors (HRBs) by testing how genetic background moderates these associations and clarifies the influence of chronotypes and polygenic risk score (PRS) on adolescent HRBs. Methods Using VOS-viewer software to select the corresponding data, this study used knowledge domain mapping to identify and develop the research direction with respect to adolescent risk factor type. Next, DNA samples from 264 students were collected for low-depth whole-genome sequencing. The sequencing detected HRB risk loci, 49 single nucleotide polymorphisms based to significant SNP. Subsequently, PRSs were assessed and divided into low, moderate, and high genetic risk according to the tertiles and chronotypes and interaction models were constructed to evaluate the association of interaction effect and clustering of adolescent HRBs. The chronotypes and the association between CLOCK-PRS and HRBs were examined to explore the association between chronotypes and mental health and circadian CLOCK-PRS and HRBs. Results Four prominent areas were displayed by clustering information fields in network and density visualization modes in VOS-viewer. The total score of evening chronotypes correlated with high-level clustering of HRBs in adolescents, co-occurrence, and mental health, and the difference was statistically significant. After controlling covariates, the results remained consistent. Three-way interactions between chronotype, age, and mental health were observed, and the differences were statistically significant. CLOCK-PRS was constructed to identify genetic susceptibility to the clustering of HRBs. The interaction of evening chronotypes and high genetic risk CLOCK-PRS was positively correlated with high-level clustering of HRBs and HRB co-occurrence in adolescents, and the difference was statistically significant. The interaction between the sub-dimensions of evening chronotypes and the high genetic CLOCK-PRS risk correlated with the outcome of the clustering of HRBs and HRB co-occurrence. Conclusions The interaction of PRS and chronotype and the HRBs in adolescents appear to have an association, and the three-way interaction between the CLOCK-PRS, chronotype, and mental health plays important roles for HRBs in adolescents.

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Animal Model Approaches to Understanding the Neurobiology of Suicidal Behavior

Romay-Tallón

Pinna

2022

Neuromethods

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Suicide attempts in children and adolescents: The place of clock genes and early rhythm dysfunction

Cited by 5 publications

References 97 publications

The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents

The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents

Role of polygenic risk scores in the association between chronotype and health risk behaviors

Animal Model Approaches to Understanding the Neurobiology of Suicidal Behavior

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