Sucrose solutions as prospective medium to study the vesicle structure: SAXS and SANS study

Киселев, М. А.; Lesieur, P.; Kisselev, A.M.; Lombardo, Domenico; Killany, M.; Lesieur, Sylviane

doi:10.1016/s0925-8388(01)01348-2

Cited by 39 publications

(28 citation statements)

References 18 publications

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“…This model is well described by Pedersen [10] and was used for describing small angle scattering curves for micelles of block copolymers [11][12][13][14] and surfactant vesicles [15]. Assuming that each micelle has the average volume V mic , the volume fraction defined by φ = N p V mic /V = n p V mic , can be inserted in the calculated intensity which yields in the DA and LMA…”

Section: Diluted Liquid Phasementioning

confidence: 99%

“…We start here with Eq. (15) to determine the number of water molecules per EO assuming that the aggregation number is the right one (this involves the assumption that the radius and the electron density of the core are correct). From this we can derive the volume of the PEO in the shell and thus the volume of water bound to the shell.…”

Section: Important Consequencesmentioning

confidence: 99%

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Binary Phase Diagram of Water/Brij58 Studied by SAXS

et al. 2012

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The phase diagram of the binary water/Brij58 system has been studied at constant temperature T = 20• C first by simple optical observation and then by small angle X-ray scattering. The small angle X-ray scattering patterns in the isotropic diluted phase are analyzed in a quantitative way by refining the experimental measurements with a model assuming hard spherical micelles in interaction. The micelles are described by a poly dispersed core-shell model and the interaction by the Perkus-Yevick hard-sphere model. The fitted parameters are analyzed in detail to determine the way polyoxyethylene blocks are hydrated with respect to the volumic fraction of water. In the more concentrated regime, the crystalline phases that are identified are the F m3m cubic, the 2D hexagonal and the lamellar phases. The structural parameters that describe each phases are analyzed and commented. The small angle X-ray scattering study is complemented by the determination of the temperature dependent liquid-solid transition by rheology.PACS: 81.30.−t, 61.05.C−, 64.70.dg IntroductionThe full understanding of the properties of surfactants when added to oil and water is of considerable interest given their tremendous applications in many scientific fields such as the design of hybrid mesoporous materials, drug delivery, or more prosaically industrial applications of detergents. Among widely used surfactants one finds the non-ionic surfactant of the Brij family characterized by a hydrophilic head made of polyoxyethylene (PEO) and a hydrophobic tail made of an alkyl chain. Quite surprisingly very little information is found in the literature about the phase diagram of the Brij58 (polyoxyethylene(20) cetyl ether). Apart from a neutron study of Brij58 micelles made by Sheffer et al. [1] by small angle neutron scattering and the study done by Mitchell on the phase behavior of polyoxyethylene surfactants with water, no real analysis of the phase diagram is available to the best of our knowledge [1][2][3].Our objective in this paper is to present the small angle X-ray scattering (SAXS) determination of the structures developed by the Brij58 when mixed with water from 5% to 95% in weight at a constant temperature of 20

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Section: Diluted Liquid Phasementioning

confidence: 99%

Section: Important Consequencesmentioning

confidence: 99%

Binary Phase Diagram of Water/Brij58 Studied by SAXS

et al. 2012

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“…The small-angle scattering of neutrons (SANS) and of X-rays (SAXS) is the well known experimental technique that uses the elastic neutron scattering and the X-ray scattering at small angles to study the structure of various substances at a scale of about 1-100 nm [1,2]. This technique is widely utilized for investigation of unilamellar phospholipid vesicles (ULVs) with different chemical compositions in large water excess, see [3,4,5,6] and references therein.…”

Section: Introductionmentioning

confidence: 99%

The Small-Angle Neutron Scattering Data Analysis of the Phospholipid Transport Nanosystem Structure

Zemlyanaya

Киселев

Zhabitskaya

et al. 2018

J. Phys.: Conf. Ser.

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Abstract. The small-angle neutron scattering technique (SANS) is employed for investigation of structure of the phospholipid transport nanosystem (PTNS) elaborated in the V.N.Orekhovich Institute of Biomedical Chemistry (Moscow, Russia). The SANS spectra have been measured at the YuMO small-angle spectrometer of IBR-2 reactor (Joint Institute of Nuclear Research, Dubna, Russia). Basic characteristics of polydispersed population of PTNS unilamellar vesicles (average radius of vesicles, polydispersity, thickness of membrane, etc.) have been determined in three cases of the PTNS concentrations in D2O: 5%, 10%, and 25%. Numerical analysis is based on the separated form factors method (SFF). The results are discussed in comparison with the results of analysis of the small-angle X-ray scattering spectra collected at the Kurchatov Synchrotron Radiation

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“…The small angle scattering of neutrons (SANS) and of Xrays (SAXS) are known as powerful tools for the nanosystems structure investigation. SANS and SAXS measurements are well suited for the analysis of the structure of the polydispersed populations of unilamellar vesicles (ULVs) of phospholipids in water solutions of disaccharides [3][4][5][6]. For this analysis, we utilize the separated form factors method (SFF) [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Determination of the Vesicular Systems Parameters: Parallel Implementation and Analysis of the PTNS Vesicle Structure

et al. 2018

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Abstract. Parameters of the phospholipid vesicular systems are determined by means of minimization of the discrepancy between experimental data on the small angle scattering intensity and the numerical results within the frame of the separated form factors method. Effectiveness of parallel implementation is tested at the cluster HybriLIT. Results of numerical analysis of small angle neutron scattering data on polydispersed population of unilamellar vesicles of phospholipid transport nanosystem are presented.

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Sucrose solutions as prospective medium to study the vesicle structure: SAXS and SANS study

Cited by 39 publications

References 18 publications

Binary Phase Diagram of Water/Brij58 Studied by SAXS

Binary Phase Diagram of Water/Brij58 Studied by SAXS

The Small-Angle Neutron Scattering Data Analysis of the Phospholipid Transport Nanosystem Structure

Determination of the Vesicular Systems Parameters: Parallel Implementation and Analysis of the PTNS Vesicle Structure

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